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IONIS PHARMACEUTICAL
IONIS PHARMACEUTICAL. Institutional holdings reported to the SEC.

Institutional Holders (2015Q2)
Portfolio Summary: 390 Institutional holders with a total value of $5,850,891,360.
#
Manager Name
Shares
Value ($)
%
Options
Notes
101 ROYAL BANK OF CANADA 100,000 5,755,000 0.10% Put
102 Tekla Capital Management LLC 98,200 5,651,000 0.10%
103 Tekla Capital Management LLC 98,200 5,651,000 0.10% Call
104 QS Investors, LLC 97,978 5,639,000 0.10%
105 RUSSELL FRANK CO/ 94,960 5,461,000 0.09%
106 Rhenman & Partners Asset Management AB 94,000 5,410,000 0.09%
107 BARCLAYS PLC 94,900 5,409,000 0.09% Call
108 STATE OF WISCONSIN INVESTMENT BOARD 91,900 5,289,000 0.09%
109 C WorldWide Group Holding A/S 90,700 5,220,000 0.09%
110 AMP Capital Investors Ltd 92,863 5,205,000 0.09%
111 COOKSON PEIRCE & CO INC 90,200 5,191,000 0.09% SH
112 PROFUND ADVISORS LLC 89,443 5,147,000 0.09%
113 CHARTWELL INVESTMENT PARTNERS, LLC 87,000 5,007,000 0.09%
114 TCW GROUP INC 83,720 4,818,000 0.08%
115 BARCLAYS PLC 80,941 4,616,000 0.08%
116 Candriam S.C.A. 80,000 4,604,000 0.08%
117 Cubist Systematic Strategies, LLC 77,735 4,474,000 0.08%
118 Motley Fool Wealth Management, LLC 76,789 4,419,000 0.08%
119 FIL Ltd 73,627 4,238,000 0.07%
120 BARCLAYS PLC 74,000 4,218,000 0.07% Put
121 Artisan Partners Limited Partnership 73,051 4,204,000 0.07%
122 NOMURA HOLDINGS INC 70,055 4,031,000 0.07%
123 NJ State Employees Deferred Compensation Plan 70,000 4,029,000 0.07%
124 Catalyst Capital Advisors LLC 70,000 4,029,000 0.07%
125 DekaBank Deutsche Girozentrale 69,800 4,017,000 0.07%
126 Opus Point Partners Management, LLC 66,208 3,810,000 0.07%
127 CITY NATIONAL BANK 63,401 3,649,000 0.06%
128 ENVESTNET ASSET MANAGEMENT INC 60,575 3,486,000 0.06%
129 AHL Partners LLP 60,356 3,474,000 0.06%
130 Virtu KCG Holdings LLC 59,336 3,415,000 0.06%
131 Korea Investment CORP 59,300 3,413,000 0.06%
132 PARAMETRIC PORTFOLIO ASSOCIATES LLC 58,655 3,376,000 0.06%
133 BAKER BROS. ADVISORS LP 57,140 3,288,000 0.06%
134 VOYA INVESTMENT MANAGEMENT LLC 55,244 3,180,000 0.05%
135 FEDERATED HERMES, INC. 54,042 3,110,000 0.05%
136 AMERIPRISE FINANCIAL INC 53,347 3,070,000 0.05%
137 BLB&B Advisors, LLC 51,831 2,983,000 0.05%
138 RENAISSANCE TECHNOLOGIES LLC 51,314 2,953,000 0.05%
139 SIMPLEX TRADING, LLC 50,499 2,906,000 0.05%
140 Iguana Healthcare Management, LLC 50,000 2,878,000 0.05%
141 D. E. Shaw & Co., Inc. 48,569 2,795,000 0.05%
142 SPHERA FUNDS MANAGEMENT LTD. 48,000 2,762,000 0.05%
143 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 47,936 2,759,000 0.05%
144 STEVENS CAPITAL MANAGEMENT LP 45,750 2,633,000 0.05%
145 MACQUARIE GROUP LTD 45,084 2,595,000 0.04%
146 Parallax Volatility Advisers, L.P. 44,600 2,567,000 0.04% Put
147 Princeton Alpha Management LP 43,983 2,531,000 0.04%
148 NATIXIS ADVISORS, LLC 43,880 2,525,000 0.04%
149 TWO SIGMA ADVISERS, LP 43,805 2,521,000 0.04%
150 JPMORGAN CHASE & CO 42,101 2,423,000 0.04%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.