| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,934,154 | 182,491,000 | 48.07% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,377,030 | 56,363,000 | 14.85% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,184,047 | 36,190,000 | 9.53% | ||
| 4 | BlackRock Finance, Inc. | 1,575,446 | 26,295,000 | 6.93% | ||
| 5 | FRANKLIN RESOURCES INC | 1,320,245 | 22,035,000 | 5.80% | ||
| 6 | GOLDMAN SACHS GROUP INC | 967,832 | 16,153,000 | 4.26% | ||
| 7 | BOXER CAPITAL, LLC | 877,753 | 14,650,000 | 3.86% | ||
| 8 | VANGUARD GROUP INC | 265,028 | 4,423,000 | 1.17% | ||
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 175,000 | 2,921,000 | 0.77% | ||
| 10 | Alyeska Investment Group, L.P. | 146,159 | 2,439,000 | 0.64% | ||
| 11 | ROYCE & ASSOCIATES LP | 145,397 | 2,427,000 | 0.64% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 121,532 | 2,028,000 | 0.53% | ||
| 13 | EMORY UNIVERSITY | 112,062 | 1,870,000 | 0.49% | ||
| 14 | TD ASSET MANAGEMENT INC | 84,644 | 1,413,000 | 0.37% | ||
| 15 | NORTHERN TRUST CORP | 80,516 | 1,344,000 | 0.35% | ||
| 16 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,800 | 948,000 | 0.25% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 835,000 | 0.22% | ||
| 18 | Polar Capital LLP | 40,000 | 668,000 | 0.18% | ||
| 19 | DEUTSCHE BANK AG\ | 30,727 | 511,000 | 0.13% | ||
| 20 | NORGES BANK | 25,738 | 430,000 | 0.11% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,900 | 399,000 | 0.11% | Call | |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,200 | 371,000 | 0.10% | Put | |
| 23 | MORGAN STANLEY | 20,371 | 340,000 | 0.09% | ||
| 24 | ALPS ADVISORS INC | 20,151 | 336,000 | 0.09% | ||
| 25 | Bank of New York Mellon Corp | 19,961 | 333,000 | 0.09% | ||
| 26 | ProShare Advisors LLC | 12,502 | 209,000 | 0.06% | ||
| 27 | Archon Partners LLC | 12,500 | 209,000 | 0.06% | ||
| 28 | GROUP ONE TRADING LLC | 11,996 | 200,000 | 0.05% | ||
| 29 | STATE STREET CORP | 11,700 | 195,000 | 0.05% | ||
| 30 | INVESTMENT CENTERS OF AMERICA INC | 10,363 | 172,000 | 0.05% | ||
| 31 | D.A. DAVIDSON & CO. | 10,050 | 167,000 | 0.04% | ||
| 32 | CUTLER GROUP LLC / CA | 3,800 | 63,000 | 0.02% | ||
| 33 | BANK OF MONTREAL /CAN/ | 2,905 | 48,000 | 0.01% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 2,232 | 37,000 | 0.01% | ||
| 35 | SIMPLEX TRADING, LLC | 2,180 | 36,000 | 0.01% | ||
| 36 | CITIGROUP INC | 1,470 | 25,000 | 0.01% | ||
| 37 | Tower Research Capital LLC (TRC) | 929 | 16,000 | 0.00% | ||
| 38 | CUTLER GROUP LLC / CA | 4,000 | 13,000 | 0.00% | Call | |
| 39 | CUTLER GROUP LLC / CA | 81,800 | 10,000 | 0.00% | Put | |
| 40 | BARCLAYS PLC | 177 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
