| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,129,385 | 652,028,000 | 13.49% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,662,060 | 300,097,000 | 6.21% | ||
| 3 | VANGUARD GROUP INC | 4,554,070 | 293,145,000 | 6.06% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 4,438,957 | 285,734,000 | 5.91% | ||
| 5 | FRANKLIN RESOURCES INC | 4,425,923 | 284,896,000 | 5.89% | ||
| 6 | ORBIMED ADVISORS LLC | 2,724,100 | 175,350,000 | 3.63% | ||
| 7 | BLAIR WILLIAM & CO/IL | 2,449,494 | 157,673,000 | 3.26% | ||
| 8 | Knoll Capital Management, LLC | 2,279,519 | 146,733,000 | 3.03% | ||
| 9 | WELLS FARGO & COMPANY/MN | 2,279,976 | 146,631,000 | 3.03% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 2,265,487 | 145,829,000 | 3.02% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,885,457 | 121,367,000 | 2.51% | ||
| 12 | LORD, ABBETT & CO. LLC | 1,817,579 | 116,998,000 | 2.42% | ||
| 13 | BlackRock Fund Advisors | 1,514,378 | 97,481,000 | 2.02% | ||
| 14 | COLUMBUS CIRCLE INVESTORS | 1,501,632 | 96,660,000 | 2.00% | ||
| 15 | Invesco Ltd. | 1,490,249 | 95,928,000 | 1.98% | ||
| 16 | BB BIOTECH AG | 1,459,706 | 93,961,000 | 1.94% | ||
| 17 | Bain Capital Public Equity Management, LLC | 1,417,590 | 91,250,000 | 1.89% | ||
| 18 | WADDELL & REED FINANCIAL INC | 1,267,248 | 81,573,000 | 1.69% | ||
| 19 | STATE STREET CORP | 1,145,013 | 73,706,000 | 1.52% | ||
| 20 | DEUTSCHE BANK AG\ | 1,060,961 | 68,287,000 | 1.41% | ||
| 21 | HealthCor Management, L.P. | 1,000,000 | 64,370,000 | 1.33% | ||
| 22 | GOLDMAN SACHS GROUP INC | 895,896 | 57,668,000 | 1.19% | ||
| 23 | OppenheimerFunds, Inc. | 889,791 | 57,276,000 | 1.18% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 816,322 | 52,547,000 | 1.09% | ||
| 25 | NORGES BANK | 714,793 | 46,011,000 | 0.95% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 603,100 | 38,822,000 | 0.80% | Put | |
| 27 | Cormorant Asset Management, LP | 600,000 | 38,622,000 | 0.80% | ||
| 28 | RAINIER INVESTMENT MANAGEMENT LLC | 463,220 | 29,816,000 | 0.62% | ||
| 29 | Allianz Asset Management GmbH | 450,600 | 29,005,000 | 0.60% | ||
| 30 | NORTHERN TRUST CORP | 407,386 | 26,225,000 | 0.54% | ||
| 31 | TIVERTON ASSET MANAGEMENT LLC | 400,000 | 25,749,000 | 0.53% | ||
| 32 | BNP Paribas Asset Management Holding S.A. | 388,292 | 24,995,000 | 0.52% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 377,692 | 24,312,000 | 0.50% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 376,700 | 24,248,000 | 0.50% | Call | |
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 359,356 | 23,132,000 | 0.48% | ||
| 36 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 350,000 | 22,530,000 | 0.47% | Call | |
| 37 | Bank of New York Mellon Corp | 309,681 | 19,934,000 | 0.41% | ||
| 38 | BLACKROCK ADVISORS LLC | 292,094 | 18,802,000 | 0.39% | ||
| 39 | UBS AG | 284,043 | 18,284,000 | 0.38% | ||
| 40 | EVENTIDE ASSET MANAGEMENT, LLC | 264,500 | 17,026,000 | 0.35% | ||
| 41 | FIRST TRUST ADVISORS LP | 259,882 | 16,729,000 | 0.35% | ||
| 42 | Apex Capital Management | 255,938 | 16,475,000 | 0.34% | ||
| 43 | PFM Health Sciences, LP | 255,105 | 16,421,000 | 0.34% | ||
| 44 | SENZAR ASSET MANAGEMENT, LLC | 251,100 | 16,163,000 | 0.33% | ||
| 45 | STATE OF MICHIGAN RETIREMENT SYSTEM | 243,100 | 15,648,000 | 0.32% | ||
| 46 | MANAGED ACCOUNT ADVISORS LLC | 240,618 | 15,489,000 | 0.32% | ||
| 47 | CREDIT SUISSE AG/ | 239,645 | 15,426,000 | 0.32% | ||
| 48 | PALISADE CAPITAL MANAGEMENT, LP | 234,491 | 15,094,000 | 0.31% | ||
| 49 | VAN ECK ASSOCIATES CORP | 221,720 | 14,272,000 | 0.30% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 218,595 | 14,071,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
