| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,520,129 | 1,147,520,000 | 15.67% | ||
| 2 | VANGUARD GROUP INC | 4,669,973 | 465,176,000 | 6.35% | ||
| 3 | FRANKLIN RESOURCES INC | 2,959,987 | 294,847,000 | 4.03% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,713,903 | 270,332,000 | 3.69% | ||
| 5 | ORBIMED ADVISORS LLC | 2,268,900 | 226,005,000 | 3.09% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,230,276 | 222,158,000 | 3.03% | ||
| 7 | Knoll Capital Management, LLC | 2,244,519 | 221,584,000 | 3.03% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,129,000 | 212,070,000 | 2.90% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,929,250 | 192,173,000 | 2.62% | ||
| 10 | BLAIR WILLIAM & CO/IL | 1,709,055 | 170,239,000 | 2.32% | ||
| 11 | BlackRock Fund Advisors | 1,552,839 | 154,678,000 | 2.11% | ||
| 12 | Invesco Ltd. | 1,473,329 | 146,760,000 | 2.00% | ||
| 13 | BB BIOTECH AG | 1,384,706 | 137,931,000 | 1.88% | ||
| 14 | STATE STREET CORP | 1,383,600 | 137,830,000 | 1.88% | ||
| 15 | WELLS FARGO & COMPANY/MN | 1,337,405 | 133,219,000 | 1.82% | ||
| 16 | FIRST TRUST ADVISORS LP | 1,196,422 | 119,176,000 | 1.63% | ||
| 17 | WADDELL & REED FINANCIAL INC | 1,157,616 | 115,310,000 | 1.57% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,113,643 | 110,930,000 | 1.51% | ||
| 19 | OppenheimerFunds, Inc. | 1,007,871 | 100,394,000 | 1.37% | ||
| 20 | DEUTSCHE BANK AG\ | 941,837 | 93,810,000 | 1.28% | ||
| 21 | 1832 Asset Management L.P. | 898,200 | 88,444,000 | 1.21% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 750,682 | 74,775,000 | 1.02% | ||
| 23 | D. E. Shaw & Co., Inc. | 738,672 | 73,579,000 | 1.00% | ||
| 24 | Bain Capital Public Equity Management, LLC | 639,021 | 63,653,000 | 0.87% | ||
| 25 | NORGES BANK | 620,417 | 61,799,000 | 0.84% | ||
| 26 | HealthCor Management, L.P. | 575,000 | 57,276,000 | 0.78% | ||
| 27 | FRONTIER CAPITAL MANAGEMENT CO LLC | 561,592 | 55,940,000 | 0.76% | ||
| 28 | Allianz Asset Management GmbH | 556,391 | 55,422,000 | 0.76% | ||
| 29 | Apex Capital Management | 551,251 | 54,910,000 | 0.75% | ||
| 30 | NORTHERN TRUST CORP | 537,609 | 53,551,000 | 0.73% | ||
| 31 | VOYA INVESTMENT MANAGEMENT LLC | 529,313 | 52,725,000 | 0.72% | ||
| 32 | Tourbillon Capital Partners, L.P. | 500,000 | 49,805,000 | 0.68% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 481,131 | 47,925,000 | 0.65% | ||
| 34 | CITADEL ADVISORS LLC | 465,149 | 46,333,000 | 0.63% | ||
| 35 | MARSHALL WACE, LLP | 443,456 | 44,172,000 | 0.60% | ||
| 36 | WESTFIELD CAPITAL MANAGEMENT CO LP | 421,750 | 42,011,000 | 0.57% | ||
| 37 | LORD, ABBETT & CO. LLC | 411,559 | 40,995,000 | 0.56% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 405,023 | 40,321,000 | 0.55% | ||
| 39 | TIVERTON ASSET MANAGEMENT LLC | 400,000 | 39,845,000 | 0.54% | ||
| 40 | BNP Paribas Asset Management Holding S.A. | 396,766 | 39,522,000 | 0.54% | ||
| 41 | CREDIT SUISSE AG/ | 379,046 | 37,756,000 | 0.52% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 357,900 | 35,650,000 | 0.49% | Put | |
| 43 | SECTORAL ASSET MANAGEMENT INC | 356,806 | 35,541,000 | 0.49% | ||
| 44 | COLUMBUS CIRCLE INVESTORS | 351,138 | 34,977,000 | 0.48% | ||
| 45 | Bank of New York Mellon Corp | 333,803 | 33,250,000 | 0.45% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 325,500 | 32,423,000 | 0.44% | Call | |
| 47 | RAINIER INVESTMENT MANAGEMENT LLC | 317,960 | 31,673,000 | 0.43% | ||
| 48 | UBS Group AG | 301,269 | 30,009,000 | 0.41% | ||
| 49 | ING GROEP NV | 289,886 | 28,899,000 | 0.39% | ||
| 50 | BLACKROCK ADVISORS LLC | 282,570 | 28,147,000 | 0.38% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
