| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 24,006,067 | 1,103,799,000 | 15.90% | ||
| 2 | VANGUARD GROUP INC | 11,697,051 | 537,830,000 | 7.75% | ||
| 3 | Knoll Capital Management, LLC | 4,397,838 | 202,213,000 | 2.91% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 3,911,801 | 179,865,000 | 2.59% | ||
| 5 | STATE STREET CORP | 3,680,057 | 169,211,000 | 2.44% | ||
| 6 | BlackRock Fund Advisors | 3,619,897 | 166,443,000 | 2.40% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 3,543,891 | 162,950,000 | 2.35% | ||
| 8 | TimesSquare Capital Management, LLC | 3,127,600 | 143,807,000 | 2.07% | ||
| 9 | DEUTSCHE BANK AG\ | 3,095,197 | 142,309,000 | 2.05% | ||
| 10 | SCOPIA CAPITAL MANAGEMENT LP | 2,804,911 | 128,970,000 | 1.86% | ||
| 11 | BB BIOTECH AG | 2,581,112 | 118,680,000 | 1.71% | ||
| 12 | ING GROEP NV | 2,459,367 | 113,057,000 | 1.63% | ||
| 13 | GOLDMAN SACHS GROUP INC | 2,202,177 | 101,257,000 | 1.46% | ||
| 14 | FRONTIER CAPITAL MANAGEMENT CO LLC | 2,172,009 | 99,869,000 | 1.44% | ||
| 15 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 2,149,174 | 98,819,000 | 1.42% | ||
| 16 | PointState Capital LP | 2,067,361 | 95,057,000 | 1.37% | ||
| 17 | HealthCor Management, L.P. | 2,015,000 | 92,650,000 | 1.33% | ||
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,009,600 | 92,401,000 | 1.33% | ||
| 19 | FRANKLIN RESOURCES INC | 1,952,808 | 89,790,000 | 1.29% | ||
| 20 | Redmile Group, LLC | 1,786,599 | 82,148,000 | 1.18% | ||
| 21 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,780,000 | 81,844,000 | 1.18% | ||
| 22 | Jupiter Investment Management Ltd | 1,622,283 | 74,592,000 | 1.07% | ||
| 23 | Bain Capital Public Equity Management, LLC | 1,518,063 | 69,801,000 | 1.01% | ||
| 24 | AQR CAPITAL MANAGEMENT LLC | 1,505,118 | 69,205,000 | 1.00% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,492,831 | 68,640,000 | 0.99% | ||
| 26 | Invesco Ltd. | 1,444,581 | 66,422,000 | 0.96% | ||
| 27 | CITADEL ADVISORS LLC | 1,380,615 | 63,481,000 | 0.91% | ||
| 28 | Consonance Capital Management LP | 1,350,000 | 62,073,000 | 0.89% | ||
| 29 | BLACKROCK ADVISORS LLC | 1,286,929 | 59,173,000 | 0.85% | ||
| 30 | BlackRock Group LTD | 1,286,697 | 59,164,000 | 0.85% | ||
| 31 | Apex Capital Management | 1,277,879 | 58,757,000 | 0.85% | ||
| 32 | PUTNAM INVESTMENTS LLC | 1,267,111 | 58,261,000 | 0.84% | ||
| 33 | WADDELL & REED FINANCIAL INC | 1,234,512 | 56,763,000 | 0.82% | ||
| 34 | BNP Paribas Asset Management Holding S.A. | 1,064,695 | 48,954,000 | 0.71% | ||
| 35 | FIRST TRUST ADVISORS LP | 1,051,546 | 48,350,000 | 0.70% | ||
| 36 | BALYASNY ASSET MANAGEMENT L.P. | 1,045,560 | 48,075,000 | 0.69% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 1,023,551 | 47,034,000 | 0.68% | ||
| 38 | TORRAY INVESTMENT PARTNERS LLC | 1,005,770 | 46,245,000 | 0.67% | ||
| 39 | D. E. Shaw & Co., Inc. | 963,179 | 44,287,000 | 0.64% | ||
| 40 | NORGES BANK | 932,537 | 42,878,000 | 0.62% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 923,597 | 42,467,000 | 0.61% | ||
| 42 | NORTHERN TRUST CORP | 908,788 | 41,787,000 | 0.60% | ||
| 43 | CREDIT SUISSE AG/ | 838,861 | 38,570,000 | 0.56% | ||
| 44 | Camber Capital Management LP | 825,000 | 37,934,000 | 0.55% | ||
| 45 | HOLLAND CAPITAL MANAGEMENT LLC | 756,697 | 34,793,000 | 0.50% | ||
| 46 | WESTFIELD CAPITAL MANAGEMENT CO LP | 730,823 | 33,603,000 | 0.48% | ||
| 47 | Bank of New York Mellon Corp | 712,292 | 32,751,000 | 0.47% | ||
| 48 | VIKING GLOBAL INVESTORS LP | 707,319 | 32,523,000 | 0.47% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 680,488 | 31,289,000 | 0.45% | ||
| 50 | Tekla Capital Management LLC | 667,300 | 30,682,000 | 0.44% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
