| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 22,663,027 | 963,179,000 | 14.95% | ||
| 2 | VANGUARD GROUP INC | 10,910,141 | 463,681,000 | 7.20% | ||
| 3 | WELLS FARGO & COMPANY/MN | 4,999,873 | 212,495,000 | 3.30% | ||
| 4 | Knoll Capital Management, LLC | 4,397,838 | 186,908,000 | 2.90% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 3,906,656 | 166,033,000 | 2.58% | ||
| 6 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 3,772,600 | 160,336,000 | 2.49% | ||
| 7 | BlackRock Fund Advisors | 3,750,539 | 159,398,000 | 2.47% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,715,000 | 157,888,000 | 2.45% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 3,585,257 | 152,373,000 | 2.37% | ||
| 10 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,195,191 | 135,796,000 | 2.11% | ||
| 11 | STATE STREET CORP | 3,181,332 | 135,242,000 | 2.10% | ||
| 12 | FIRST TRUST ADVISORS LP | 2,582,598 | 109,760,000 | 1.70% | ||
| 13 | BB BIOTECH AG | 2,581,112 | 109,697,000 | 1.70% | ||
| 14 | AQR CAPITAL MANAGEMENT LLC | 2,463,789 | 104,711,000 | 1.63% | ||
| 15 | DEUTSCHE BANK AG\ | 2,326,056 | 98,848,000 | 1.53% | ||
| 16 | TimesSquare Capital Management, LLC | 2,239,800 | 95,192,000 | 1.48% | ||
| 17 | FRANKLIN RESOURCES INC | 2,224,508 | 94,542,000 | 1.47% | ||
| 18 | Invesco Ltd. | 2,063,503 | 87,699,000 | 1.36% | ||
| 19 | D. E. Shaw & Co., Inc. | 1,940,630 | 82,477,000 | 1.28% | ||
| 20 | HealthCor Management, L.P. | 1,900,000 | 80,750,000 | 1.25% | ||
| 21 | Redmile Group, LLC | 1,752,642 | 74,487,000 | 1.16% | ||
| 22 | WADDELL & REED FINANCIAL INC | 1,681,504 | 71,464,000 | 1.11% | ||
| 23 | Point72 Asset Management, L.P. | 1,641,334 | 69,757,000 | 1.08% | ||
| 24 | OppenheimerFunds, Inc. | 1,508,582 | 64,115,000 | 1.00% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,486,339 | 63,169,000 | 0.98% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 1,442,958 | 61,326,000 | 0.95% | ||
| 27 | Jupiter Investment Management Ltd | 1,366,627 | 58,081,000 | 0.90% | ||
| 28 | GOLDMAN SACHS GROUP INC | 1,291,035 | 54,869,000 | 0.85% | ||
| 29 | Apex Capital Management | 1,262,107 | 53,640,000 | 0.83% | ||
| 30 | BlackRock Group LTD | 1,230,143 | 52,281,000 | 0.81% | ||
| 31 | BLACKROCK ADVISORS LLC | 1,205,349 | 51,228,000 | 0.80% | ||
| 32 | NORGES BANK | 1,200,678 | 51,028,000 | 0.79% | ||
| 33 | KALMAR INVESTMENTS INC /DE/ | 1,117,200 | 47,481,000 | 0.74% | ||
| 34 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,075,846 | 45,723,000 | 0.71% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 1,040,814 | 44,209,000 | 0.69% | ||
| 36 | NORTHERN TRUST CORP | 1,019,735 | 43,339,000 | 0.67% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,018,968 | 43,306,000 | 0.67% | ||
| 38 | Bank of New York Mellon Corp | 827,240 | 35,158,000 | 0.55% | ||
| 39 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 814,744 | 34,627,000 | 0.54% | ||
| 40 | BLAIR WILLIAM & CO/IL | 804,912 | 34,208,000 | 0.53% | ||
| 41 | GREEN VALLEY INVESTORS LLC | 800,000 | 34,000,000 | 0.53% | ||
| 42 | TIVERTON ASSET MANAGEMENT LLC | 800,000 | 34,000,000 | 0.53% | ||
| 43 | CAPITAL FUND MANAGEMENT S.A. | 797,919 | 33,912,000 | 0.53% | ||
| 44 | TORRAY INVESTMENT PARTNERS LLC | 797,015 | 33,873,000 | 0.53% | ||
| 45 | HOLLAND CAPITAL MANAGEMENT LLC | 789,938 | 33,572,000 | 0.52% | ||
| 46 | UBS Group AG | 698,173 | 29,673,000 | 0.46% | ||
| 47 | RENAISSANCE TECHNOLOGIES LLC | 694,700 | 29,525,000 | 0.46% | ||
| 48 | CREDIT SUISSE AG/ | 678,675 | 28,843,000 | 0.45% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 675,300 | 28,700,000 | 0.45% | Call | |
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 664,200 | 28,229,000 | 0.44% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
