| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,155,571 | 1,004,082,000 | 14.07% | ||
| 2 | VANGUARD GROUP INC | 4,442,876 | 439,267,000 | 6.16% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 3,722,893 | 368,081,000 | 5.16% | ||
| 4 | FRANKLIN RESOURCES INC | 3,222,697 | 318,624,000 | 4.47% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,499,000 | 247,076,000 | 3.46% | ||
| 6 | BLAIR WILLIAM & CO/IL | 2,342,299 | 231,583,000 | 3.25% | ||
| 7 | ORBIMED ADVISORS LLC | 2,273,000 | 224,732,000 | 3.15% | ||
| 8 | Knoll Capital Management, LLC | 2,244,519 | 221,916,000 | 3.11% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,955,663 | 193,356,000 | 2.71% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,854,119 | 183,317,000 | 2.57% | ||
| 11 | WELLS FARGO & COMPANY/MN | 1,683,663 | 166,463,000 | 2.33% | ||
| 12 | Invesco Ltd. | 1,670,768 | 165,188,000 | 2.31% | ||
| 13 | BlackRock Fund Advisors | 1,537,452 | 152,008,000 | 2.13% | ||
| 14 | BB BIOTECH AG | 1,429,706 | 141,355,000 | 1.98% | ||
| 15 | WADDELL & REED FINANCIAL INC | 1,360,949 | 134,557,000 | 1.89% | ||
| 16 | D. E. Shaw & Co., Inc. | 1,270,224 | 125,587,000 | 1.76% | ||
| 17 | GOLDMAN SACHS GROUP INC | 1,070,582 | 105,848,000 | 1.48% | ||
| 18 | STATE STREET CORP | 1,043,154 | 103,136,000 | 1.45% | ||
| 19 | OppenheimerFunds, Inc. | 1,003,611 | 99,227,000 | 1.39% | ||
| 20 | COLUMBUS CIRCLE INVESTORS | 910,399 | 90,011,000 | 1.26% | ||
| 21 | DEUTSCHE BANK AG\ | 837,458 | 82,792,000 | 1.16% | ||
| 22 | FIRST TRUST ADVISORS LP | 665,518 | 65,800,000 | 0.92% | ||
| 23 | NORGES BANK | 665,463 | 65,795,000 | 0.92% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 644,748 | 63,747,000 | 0.89% | ||
| 25 | LORD, ABBETT & CO. LLC | 633,795 | 62,663,000 | 0.88% | ||
| 26 | Bain Capital Public Equity Management, LLC | 623,990 | 61,694,000 | 0.86% | ||
| 27 | 1832 Asset Management L.P. | 602,900 | 58,939,000 | 0.83% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 556,938 | 55,064,000 | 0.77% | ||
| 29 | TWO SIGMA INVESTMENTS, LP | 533,599 | 52,757,000 | 0.74% | ||
| 30 | HealthCor Management, L.P. | 525,000 | 51,907,000 | 0.73% | ||
| 31 | WESTFIELD CAPITAL MANAGEMENT CO LP | 458,390 | 45,321,000 | 0.64% | ||
| 32 | BNP Paribas Asset Management Holding S.A. | 436,679 | 43,174,000 | 0.61% | ||
| 33 | Apex Capital Management | 435,970 | 43,104,000 | 0.60% | ||
| 34 | Allianz Asset Management GmbH | 419,805 | 41,506,000 | 0.58% | ||
| 35 | TIVERTON ASSET MANAGEMENT LLC | 400,000 | 39,549,000 | 0.55% | ||
| 36 | NORTHERN TRUST CORP | 393,392 | 38,894,000 | 0.55% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 390,852 | 38,642,000 | 0.54% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 390,400 | 38,599,000 | 0.54% | Put | |
| 39 | RAINIER INVESTMENT MANAGEMENT LLC | 387,650 | 38,329,000 | 0.54% | ||
| 40 | VOYA INVESTMENT MANAGEMENT LLC | 381,385 | 37,708,000 | 0.53% | ||
| 41 | PFM Health Sciences, LP | 358,585 | 35,453,000 | 0.50% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 347,700 | 34,377,000 | 0.48% | Call | |
| 43 | SECTORAL ASSET MANAGEMENT INC | 336,878 | 33,307,000 | 0.47% | ||
| 44 | Bank of New York Mellon Corp | 335,454 | 33,166,000 | 0.46% | ||
| 45 | UBS AG | 333,934 | 33,016,000 | 0.46% | ||
| 46 | FRONTIER CAPITAL MANAGEMENT CO LLC | 328,438 | 32,473,000 | 0.46% | ||
| 47 | STATE OF MICHIGAN RETIREMENT SYSTEM | 323,100 | 31,945,000 | 0.45% | ||
| 48 | CREDIT SUISSE AG/ | 322,959 | 31,931,000 | 0.45% | ||
| 49 | ING GROEP NV | 296,510 | 29,310,000 | 0.41% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 292,700 | 28,939,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
