| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 23,872,603 | 1,154,001,000 | 15.69% | ||
| 2 | VANGUARD GROUP INC | 11,369,030 | 549,579,000 | 7.47% | ||
| 3 | WELLS FARGO & COMPANY/MN | 4,731,006 | 228,696,000 | 3.11% | ||
| 4 | Knoll Capital Management, LLC | 4,397,838 | 212,591,000 | 2.89% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 4,045,414 | 195,555,000 | 2.66% | ||
| 6 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 3,523,582 | 170,330,000 | 2.32% | ||
| 7 | BlackRock Fund Advisors | 3,423,440 | 165,489,000 | 2.25% | ||
| 8 | STATE STREET CORP | 3,421,851 | 165,414,000 | 2.25% | ||
| 9 | AQR CAPITAL MANAGEMENT LLC | 3,226,191 | 155,955,000 | 2.12% | ||
| 10 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,130,798 | 151,343,000 | 2.06% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 3,024,324 | 146,195,000 | 1.99% | ||
| 12 | TimesSquare Capital Management, LLC | 2,849,100 | 137,725,000 | 1.87% | ||
| 13 | BB BIOTECH AG | 2,581,112 | 124,771,000 | 1.70% | ||
| 14 | DEUTSCHE BANK AG\ | 2,400,800 | 116,047,000 | 1.58% | ||
| 15 | FIRST TRUST ADVISORS LP | 2,360,636 | 114,113,000 | 1.55% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,324,600 | 112,371,000 | 1.53% | ||
| 17 | HealthCor Management, L.P. | 2,300,000 | 111,182,000 | 1.51% | ||
| 18 | FRONTIER CAPITAL MANAGEMENT CO LLC | 2,017,474 | 97,525,000 | 1.33% | ||
| 19 | Point72 Asset Management, L.P. | 2,002,700 | 96,811,000 | 1.32% | ||
| 20 | FRANKLIN RESOURCES INC | 1,928,608 | 93,229,000 | 1.27% | ||
| 21 | Invesco Ltd. | 1,914,505 | 92,546,000 | 1.26% | ||
| 22 | Jupiter Investment Management Ltd | 1,803,268 | 87,169,000 | 1.19% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 1,627,289 | 78,663,000 | 1.07% | ||
| 24 | CITADEL ADVISORS LLC | 1,625,249 | 78,565,000 | 1.07% | ||
| 25 | GOLDMAN SACHS GROUP INC | 1,621,791 | 78,397,000 | 1.07% | ||
| 26 | Redmile Group, LLC | 1,599,393 | 77,315,000 | 1.05% | ||
| 27 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,403,498 | 67,845,000 | 0.92% | ||
| 28 | WADDELL & REED FINANCIAL INC | 1,351,549 | 65,334,000 | 0.89% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,325,156 | 64,059,000 | 0.87% | ||
| 30 | WELLINGTON MANAGEMENT GROUP LLP | 1,285,764 | 62,155,000 | 0.85% | ||
| 31 | BlackRock Group LTD | 1,278,559 | 61,804,000 | 0.84% | ||
| 32 | Apex Capital Management | 1,255,443 | 60,688,000 | 0.83% | ||
| 33 | BLACKROCK ADVISORS LLC | 1,245,350 | 60,201,000 | 0.82% | ||
| 34 | OppenheimerFunds, Inc. | 1,121,172 | 54,198,000 | 0.74% | ||
| 35 | KALMAR INVESTMENTS INC /DE/ | 1,114,615 | 53,880,000 | 0.73% | ||
| 36 | Bain Capital Public Equity Management, LLC | 1,109,692 | 53,643,000 | 0.73% | ||
| 37 | NORGES BANK | 1,091,680 | 52,772,000 | 0.72% | ||
| 38 | D. E. Shaw & Co., Inc. | 1,081,948 | 52,301,000 | 0.71% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 1,037,076 | 50,103,000 | 0.68% | ||
| 40 | GOLDMAN SACHS GROUP INC | 1,021,800 | 49,394,000 | 0.67% | Call | |
| 41 | NORTHERN TRUST CORP | 946,260 | 45,742,000 | 0.62% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 898,362 | 43,427,000 | 0.59% | ||
| 43 | Bank of New York Mellon Corp | 832,510 | 40,244,000 | 0.55% | ||
| 44 | UBS Group AG | 826,176 | 39,937,000 | 0.54% | ||
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 799,877 | 38,667,000 | 0.53% | ||
| 46 | TORRAY INVESTMENT PARTNERS LLC | 793,000 | 38,334,000 | 0.52% | ||
| 47 | HOLLAND CAPITAL MANAGEMENT LLC | 766,678 | 37,061,000 | 0.50% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 676,816 | 32,717,000 | 0.44% | ||
| 49 | Tekla Capital Management LLC | 667,300 | 32,257,000 | 0.44% | ||
| 50 | BAKER BROS. ADVISORS LP | 659,752 | 31,892,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
