| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,734,314 | 1,514,549,000 | 15.64% | ||
| 2 | VANGUARD GROUP INC | 4,964,880 | 640,817,000 | 6.62% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,654,175 | 342,573,000 | 3.54% | ||
| 4 | WELLS FARGO & COMPANY/MN | 2,392,079 | 308,745,000 | 3.19% | ||
| 5 | ORBIMED ADVISORS LLC | 2,348,900 | 303,173,000 | 3.13% | ||
| 6 | Knoll Capital Management, LLC | 2,198,919 | 283,814,000 | 2.93% | ||
| 7 | FRANKLIN RESOURCES INC | 2,186,215 | 282,172,000 | 2.91% | ||
| 8 | Invesco Ltd. | 2,023,174 | 261,130,000 | 2.70% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,956,632 | 252,542,000 | 2.61% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,725,000 | 222,646,000 | 2.30% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 1,693,858 | 218,626,000 | 2.26% | ||
| 12 | BLAIR WILLIAM & CO/IL | 1,686,657 | 217,696,000 | 2.25% | ||
| 13 | BlackRock Fund Advisors | 1,645,208 | 212,347,000 | 2.19% | ||
| 14 | STATE STREET CORP | 1,423,477 | 183,733,000 | 1.90% | ||
| 15 | FIRST TRUST ADVISORS LP | 1,325,859 | 171,129,000 | 1.77% | ||
| 16 | BB BIOTECH AG | 1,274,706 | 164,526,000 | 1.70% | ||
| 17 | DEUTSCHE BANK AG\ | 1,273,941 | 164,420,000 | 1.70% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,168,321 | 150,795,000 | 1.56% | ||
| 19 | WADDELL & REED FINANCIAL INC | 1,053,349 | 135,955,000 | 1.40% | ||
| 20 | OppenheimerFunds, Inc. | 819,521 | 105,775,000 | 1.09% | ||
| 21 | 1832 Asset Management L.P. | 816,150 | 103,640,000 | 1.07% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 777,269 | 100,321,000 | 1.04% | ||
| 23 | VOYA INVESTMENT MANAGEMENT LLC | 713,260 | 92,061,000 | 0.95% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 598,438 | 77,240,000 | 0.80% | ||
| 25 | NORGES BANK | 598,347 | 77,228,000 | 0.80% | ||
| 26 | AQR CAPITAL MANAGEMENT LLC | 583,271 | 75,283,000 | 0.78% | ||
| 27 | Apex Capital Management | 579,372 | 74,780,000 | 0.77% | ||
| 28 | NORTHERN TRUST CORP | 542,365 | 70,003,000 | 0.72% | ||
| 29 | FRONTIER CAPITAL MANAGEMENT CO LLC | 484,490 | 62,533,000 | 0.65% | ||
| 30 | WESTFIELD CAPITAL MANAGEMENT CO LP | 461,203 | 59,527,000 | 0.61% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 460,573 | 59,416,000 | 0.61% | ||
| 32 | BLACKROCK ADVISORS LLC | 449,870 | 58,065,000 | 0.60% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 434,231 | 56,046,000 | 0.58% | ||
| 34 | Allianz Asset Management GmbH | 419,218 | 54,109,000 | 0.56% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 419,200 | 54,106,000 | 0.56% | Call | |
| 36 | TIVERTON ASSET MANAGEMENT LLC | 400,000 | 51,628,000 | 0.53% | ||
| 37 | BNP Paribas Asset Management Holding S.A. | 393,028 | 50,728,000 | 0.52% | ||
| 38 | BlackRock Group LTD | 387,008 | 49,952,000 | 0.52% | ||
| 39 | D. E. Shaw & Co., Inc. | 382,570 | 49,378,000 | 0.51% | ||
| 40 | CREDIT SUISSE AG/ | 378,920 | 48,907,000 | 0.51% | ||
| 41 | HealthCor Management, L.P. | 375,000 | 48,401,000 | 0.50% | ||
| 42 | MARSHALL WACE, LLP | 360,669 | 46,551,000 | 0.48% | ||
| 43 | Bank of New York Mellon Corp | 356,074 | 45,959,000 | 0.47% | ||
| 44 | KALMAR INVESTMENTS INC /DE/ | 342,475 | 44,203,000 | 0.46% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 340,991 | 44,012,000 | 0.45% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 331,773 | 42,822,000 | 0.44% | ||
| 47 | HOLLAND CAPITAL MANAGEMENT LLC | 323,468 | 41,750,000 | 0.43% | ||
| 48 | UBS Group AG | 318,753 | 41,141,000 | 0.42% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 297,203 | 38,360,000 | 0.40% | ||
| 50 | CITADEL ADVISORS LLC | 294,299 | 37,985,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
