| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,474,031 | 653,178,000 | 11.69% | ||
| 2 | FRANKLIN RESOURCES INC | 4,617,189 | 355,887,000 | 6.37% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 4,497,073 | 346,616,000 | 6.20% | ||
| 4 | VANGUARD GROUP INC | 4,392,324 | 338,560,000 | 6.06% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,972,060 | 306,166,000 | 5.48% | ||
| 6 | BLAIR WILLIAM & CO/IL | 2,458,698 | 189,516,000 | 3.39% | ||
| 7 | ORBIMED ADVISORS LLC | 2,446,600 | 188,584,000 | 3.38% | ||
| 8 | Knoll Capital Management, LLC | 2,279,519 | 175,705,000 | 3.14% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 2,030,132 | 156,482,000 | 2.80% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,873,730 | 144,427,000 | 2.59% | ||
| 11 | Invesco Ltd. | 1,746,147 | 134,592,000 | 2.41% | ||
| 12 | WELLS FARGO & COMPANY/MN | 1,739,875 | 134,111,000 | 2.40% | ||
| 13 | Bain Capital Public Equity Management, LLC | 1,588,890 | 122,472,000 | 2.19% | ||
| 14 | PFM Health Sciences, LP | 1,518,417 | 117,040,000 | 2.09% | ||
| 15 | BB BIOTECH AG | 1,499,706 | 115,597,000 | 2.07% | ||
| 16 | BlackRock Fund Advisors | 1,484,468 | 114,423,000 | 2.05% | ||
| 17 | LORD, ABBETT & CO. LLC | 1,328,688 | 102,437,000 | 1.83% | ||
| 18 | WADDELL & REED FINANCIAL INC | 1,272,436 | 98,080,000 | 1.76% | ||
| 19 | HealthCor Management, L.P. | 1,075,000 | 82,861,000 | 1.48% | ||
| 20 | STATE STREET CORP | 1,069,681 | 82,450,000 | 1.48% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 1,058,847 | 81,616,000 | 1.46% | ||
| 22 | DEUTSCHE BANK AG\ | 930,409 | 71,708,000 | 1.28% | ||
| 23 | OppenheimerFunds, Inc. | 911,881 | 70,288,000 | 1.26% | ||
| 24 | GOLDMAN SACHS GROUP INC | 890,387 | 68,630,000 | 1.23% | ||
| 25 | CITADEL ADVISORS LLC | 707,761 | 54,554,000 | 0.98% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 687,166 | 52,967,000 | 0.95% | ||
| 27 | NORGES BANK | 675,438 | 52,063,000 | 0.93% | ||
| 28 | D. E. Shaw & Co., Inc. | 482,306 | 37,176,000 | 0.67% | ||
| 29 | WESTFIELD CAPITAL MANAGEMENT CO LP | 474,935 | 36,608,000 | 0.66% | ||
| 30 | BNP Paribas Asset Management Holding S.A. | 441,960 | 34,066,000 | 0.61% | ||
| 31 | RAINIER INVESTMENT MANAGEMENT LLC | 439,990 | 33,915,000 | 0.61% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 413,200 | 31,850,000 | 0.57% | Put | |
| 33 | TIVERTON ASSET MANAGEMENT LLC | 400,000 | 30,832,000 | 0.55% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 386,860 | 29,819,000 | 0.53% | ||
| 35 | Allianz Asset Management GmbH | 382,020 | 29,446,000 | 0.53% | ||
| 36 | NORTHERN TRUST CORP | 350,364 | 27,007,000 | 0.48% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 316,564 | 24,401,000 | 0.44% | ||
| 38 | Bank of New York Mellon Corp | 315,984 | 24,356,000 | 0.44% | ||
| 39 | UBS AG | 296,565 | 22,860,000 | 0.41% | ||
| 40 | BLACKROCK ADVISORS LLC | 291,562 | 22,474,000 | 0.40% | ||
| 41 | Apex Capital Management | 285,407 | 21,999,000 | 0.39% | ||
| 42 | EVENTIDE ASSET MANAGEMENT, LLC | 275,300 | 21,220,000 | 0.38% | ||
| 43 | STATE OF MICHIGAN RETIREMENT SYSTEM | 273,100 | 21,051,000 | 0.38% | ||
| 44 | FIRST TRUST ADVISORS LP | 262,975 | 20,270,000 | 0.36% | ||
| 45 | CREDIT SUISSE AG/ | 245,404 | 18,916,000 | 0.34% | ||
| 46 | MANAGED ACCOUNT ADVISORS LLC | 228,876 | 17,642,000 | 0.32% | ||
| 47 | Penn Capital Management Company, LLC | 225,696 | 17,397,000 | 0.31% | ||
| 48 | MASON STREET ADVISORS, LLC | 220,282 | 16,979,000 | 0.30% | ||
| 49 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 200,000 | 15,416,000 | 0.28% | Call | |
| 50 | VAN ECK ASSOCIATES CORP | 191,158 | 14,734,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
