| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 920,400 | 8,449,000 | 27.86% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 881,907 | 8,096,000 | 26.69% | ||
| 3 | FMR LLC | 481,641 | 4,421,000 | 14.58% | ||
| 4 | Broadfin Capital, LLC | 387,721 | 3,559,000 | 11.74% | ||
| 5 | BAKER BROS. ADVISORS LP | 221,631 | 2,035,000 | 6.71% | ||
| 6 | Belmont Global Advisors, Inc. | 135,000 | 1,239,000 | 4.09% | ||
| 7 | Iguana Healthcare Management, LLC | 100,000 | 918,000 | 3.03% | ||
| 8 | Trellus Management Company, LLC | 46,300 | 425,000 | 1.40% | ||
| 9 | SSI INVESTMENT MANAGEMENT LLC | 34,335 | 316,000 | 1.04% | ||
| 10 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,225 | 259,000 | 0.85% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 20,038 | 183,000 | 0.60% | ||
| 12 | BANK OF MONTREAL /CAN/ | 12,000 | 110,000 | 0.36% | ||
| 13 | CITIGROUP INC | 11,225 | 103,000 | 0.34% | ||
| 14 | PANAGORA ASSET MANAGEMENT INC | 5,477 | 50,000 | 0.16% | ||
| 15 | UBS AG | 3,500 | 32,000 | 0.11% | ||
| 16 | BARCLAYS PLC | 3,600 | 32,000 | 0.11% | ||
| 17 | WELLS FARGO & COMPANY/MN | 3,355 | 31,000 | 0.10% | ||
| 18 | MORGAN STANLEY | 2,500 | 23,000 | 0.08% | ||
| 19 | BRAVE ASSET MANAGEMENT INC | 1,800 | 17,000 | 0.06% | ||
| 20 | DEUTSCHE BANK AG\ | 1,500 | 13,000 | 0.04% | ||
| 21 | BlackRock Investment Management, LLC | 1,029 | 9,000 | 0.03% | ||
| 22 | WFG Advisors, LP | 753 | 7,000 | 0.02% | ||
| 23 | Ground Swell Capital, LLC | 90 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
