| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,052,130 | 63,820,000 | 18.81% | ||
| 2 | FMR LLC | 2,654,659 | 55,509,000 | 16.36% | ||
| 3 | Visium Asset Management, LP | 1,187,013 | 24,820,000 | 7.32% | ||
| 4 | RTW INVESTMENTS, LP | 1,169,065 | 24,445,000 | 7.21% | ||
| 5 | Broadfin Capital, LLC | 1,165,373 | 24,368,000 | 7.18% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,124,904 | 23,523,000 | 6.93% | ||
| 7 | FRANKLIN RESOURCES INC | 965,600 | 20,191,000 | 5.95% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 699,515 | 14,627,000 | 4.31% | ||
| 9 | Allianz Asset Management GmbH | 516,517 | 10,801,000 | 3.18% | ||
| 10 | VANGUARD GROUP INC | 475,375 | 9,940,000 | 2.93% | ||
| 11 | BlackRock Fund Advisors | 355,261 | 7,429,000 | 2.19% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 336,744 | 7,041,000 | 2.08% | ||
| 13 | JENNISON ASSOCIATES LLC | 248,574 | 5,198,000 | 1.53% | ||
| 14 | Granahan Investment Management, LLC | 219,799 | 4,596,000 | 1.35% | ||
| 15 | STATE STREET CORP | 215,413 | 4,503,000 | 1.33% | ||
| 16 | Avoro Capital Advisors LLC | 211,672 | 4,426,000 | 1.30% | ||
| 17 | NORTHERN TRUST CORP | 170,290 | 3,562,000 | 1.05% | ||
| 18 | Asset Management One Co., Ltd. | 133,317 | 2,599,000 | 0.77% | ||
| 19 | SABBY MANAGEMENT, LLC | 112,184 | 2,346,000 | 0.69% | ||
| 20 | MORGAN STANLEY | 104,926 | 2,195,000 | 0.65% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 95,082 | 1,988,000 | 0.59% | ||
| 22 | Bank of New York Mellon Corp | 72,136 | 1,509,000 | 0.44% | ||
| 23 | OXFORD ASSET MANAGEMENT LLP | 71,547 | 1,496,000 | 0.44% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,500 | 1,223,000 | 0.36% | Call | |
| 25 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 55,600 | 1,163,000 | 0.34% | ||
| 26 | P.A.W. CAPITAL CORP | 54,000 | 1,129,000 | 0.33% | ||
| 27 | Belmont Global Advisors, Inc. | 50,000 | 1,045,000 | 0.31% | ||
| 28 | BlackRock Investment Management, LLC | 48,920 | 1,023,000 | 0.30% | ||
| 29 | Advisors Asset Management, Inc. | 43,011 | 899,000 | 0.26% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 41,570 | 869,000 | 0.26% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 37,300 | 780,000 | 0.23% | ||
| 32 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 36,400 | 761,000 | 0.22% | ||
| 33 | DEUTSCHE BANK AG\ | 35,101 | 733,000 | 0.22% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,195 | 610,000 | 0.18% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,900 | 583,000 | 0.17% | Put | |
| 36 | Swiss National Bank | 24,400 | 493,000 | 0.15% | ||
| 37 | TEACHERS ADVISORS, LLC | 22,986 | 481,000 | 0.14% | ||
| 38 | GSA CAPITAL PARTNERS LLP | 22,500 | 470,000 | 0.14% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 22,202 | 464,000 | 0.14% | ||
| 40 | HOLLENCREST CAPITAL MANAGEMENT | 22,092 | 462,000 | 0.14% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,579 | 452,000 | 0.13% | ||
| 42 | ELLINGTON MANAGEMENT GROUP LLC | 16,500 | 345,000 | 0.10% | ||
| 43 | GOLDMAN SACHS GROUP INC | 15,743 | 329,000 | 0.10% | ||
| 44 | Squarepoint Ops LLC | 14,500 | 303,000 | 0.09% | ||
| 45 | RHUMBLINE ADVISERS | 14,302 | 299,000 | 0.09% | ||
| 46 | NATIONAL PLANNING CORP | 18,525 | 289,000 | 0.09% | ||
| 47 | BAKER BROS. ADVISORS LP | 13,746 | 287,000 | 0.08% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 13,600 | 284,000 | 0.08% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 13,341 | 279,000 | 0.08% | ||
| 50 | BALYASNY ASSET MANAGEMENT L.P. | 12,630 | 264,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
