| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 1,911,462 | 18,369,000 | 25.49% | ||
| 2 | Broadfin Capital, LLC | 1,107,046 | 10,639,000 | 14.76% | ||
| 3 | FMR LLC | 1,106,641 | 10,635,000 | 14.76% | ||
| 4 | FRANKLIN RESOURCES INC | 920,400 | 8,845,000 | 12.27% | ||
| 5 | Visium Asset Management, LP | 575,000 | 5,526,000 | 7.67% | ||
| 6 | BAKER BROS. ADVISORS LP | 421,631 | 4,052,000 | 5.62% | ||
| 7 | VANGUARD GROUP INC | 317,744 | 3,054,000 | 4.24% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 250,000 | 2,403,000 | 3.33% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 223,330 | 2,146,000 | 2.98% | ||
| 10 | Belmont Global Advisors, Inc. | 211,900 | 2,036,000 | 2.82% | ||
| 11 | Iguana Healthcare Management, LLC | 180,000 | 1,730,000 | 2.40% | ||
| 12 | SSI INVESTMENT MANAGEMENT LLC | 48,870 | 469,000 | 0.65% | ||
| 13 | Trellus Management Company, LLC | 42,800 | 411,000 | 0.57% | ||
| 14 | MORGAN STANLEY | 41,959 | 403,000 | 0.56% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 35,481 | 340,000 | 0.47% | ||
| 16 | BlackRock Fund Advisors | 27,093 | 260,000 | 0.36% | ||
| 17 | TFS CAPITAL LLC | 18,786 | 181,000 | 0.25% | ||
| 18 | NORTHERN TRUST CORP | 14,913 | 143,000 | 0.20% | ||
| 19 | A.R.T. Advisors, LLC | 14,678 | 141,000 | 0.20% | ||
| 20 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 11,389 | 110,000 | 0.15% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 5,082 | 49,000 | 0.07% | ||
| 22 | WELLS FARGO & COMPANY/MN | 3,355 | 32,000 | 0.04% | ||
| 23 | UBS AG | 2,800 | 27,000 | 0.04% | ||
| 24 | NEXT Financial Group, Inc | 2,750 | 26,000 | 0.04% | ||
| 25 | BlackRock Investment Management, LLC | 2,093 | 20,000 | 0.03% | ||
| 26 | BRAVE ASSET MANAGEMENT INC | 1,800 | 17,000 | 0.02% | ||
| 27 | WFG Advisors, LP | 380 | 4,000 | 0.01% | ||
| 28 | Tower Research Capital LLC (TRC) | 278 | 3,000 | 0.00% | ||
| 29 | Ground Swell Capital, LLC | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
