| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 2,144,387 | 39,564,000 | 22.44% | ||
| 2 | Broadfin Capital, LLC | 1,121,370 | 20,689,000 | 11.74% | ||
| 3 | FMR LLC | 1,106,641 | 20,418,000 | 11.58% | ||
| 4 | RTW INVESTMENTS, LP | 1,064,247 | 19,635,000 | 11.14% | ||
| 5 | FRANKLIN RESOURCES INC | 920,400 | 16,981,000 | 9.63% | ||
| 6 | Visium Asset Management, LP | 575,000 | 10,609,000 | 6.02% | ||
| 7 | BAKER BROS. ADVISORS LP | 421,631 | 7,779,000 | 4.41% | ||
| 8 | VANGUARD GROUP INC | 327,244 | 6,038,000 | 3.42% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 288,955 | 5,331,000 | 3.02% | ||
| 10 | Ghost Tree Capital, LLC | 286,053 | 5,278,000 | 2.99% | ||
| 11 | Avoro Capital Advisors LLC | 246,499 | 4,548,000 | 2.58% | ||
| 12 | Granahan Investment Management, LLC | 194,578 | 3,590,000 | 2.04% | ||
| 13 | Belmont Global Advisors, Inc. | 185,100 | 3,415,000 | 1.94% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 100,230 | 1,849,000 | 1.05% | ||
| 15 | Informed Momentum Co LLC | 96,064 | 1,772,000 | 1.01% | ||
| 16 | MORGAN STANLEY | 74,435 | 1,373,000 | 0.78% | ||
| 17 | D. E. Shaw & Co., Inc. | 65,878 | 1,215,000 | 0.69% | ||
| 18 | ROYCE & ASSOCIATES LP | 60,000 | 1,107,000 | 0.63% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 56,871 | 1,048,000 | 0.59% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 44,209 | 816,000 | 0.46% | ||
| 21 | BlackRock Fund Advisors | 32,426 | 598,000 | 0.34% | ||
| 22 | DEUTSCHE BANK AG\ | 30,000 | 553,000 | 0.31% | ||
| 23 | P.A.W. CAPITAL CORP | 25,000 | 461,000 | 0.26% | ||
| 24 | Creative Planning | 24,600 | 454,000 | 0.26% | ||
| 25 | Trellus Management Company, LLC | 17,152 | 316,000 | 0.18% | ||
| 26 | NORTHERN TRUST CORP | 16,325 | 301,000 | 0.17% | ||
| 27 | TFS CAPITAL LLC | 13,462 | 248,000 | 0.14% | ||
| 28 | UBS Group AG | 4,311 | 80,000 | 0.05% | ||
| 29 | WELLS FARGO & COMPANY/MN | 3,355 | 62,000 | 0.04% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 3,273 | 60,000 | 0.03% | ||
| 31 | BlackRock Investment Management, LLC | 1,988 | 37,000 | 0.02% | ||
| 32 | BRAVE ASSET MANAGEMENT INC | 1,800 | 33,000 | 0.02% | ||
| 33 | BLACKROCK ADVISORS LLC | 1,280 | 24,000 | 0.01% | ||
| 34 | Creative Planning | 1,000 | 8,000 | 0.00% | Call | |
| 35 | WFG Advisors, LP | 120 | 2,000 | 0.00% | ||
| 36 | Tower Research Capital LLC (TRC) | 30 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
