| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 2,144,387 | 39,242,000 | 21.22% | ||
| 2 | FMR LLC | 1,906,167 | 34,883,000 | 18.87% | ||
| 3 | RTW INVESTMENTS, LP | 1,064,247 | 19,476,000 | 10.53% | ||
| 4 | FRANKLIN RESOURCES INC | 920,400 | 16,843,000 | 9.11% | ||
| 5 | Broadfin Capital, LLC | 703,470 | 12,874,000 | 6.96% | ||
| 6 | Visium Asset Management, LP | 655,800 | 12,001,000 | 6.49% | ||
| 7 | Avoro Capital Advisors LLC | 461,499 | 8,445,000 | 4.57% | ||
| 8 | BAKER BROS. ADVISORS LP | 412,008 | 7,540,000 | 4.08% | ||
| 9 | VANGUARD GROUP INC | 350,270 | 6,410,000 | 3.47% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 252,915 | 4,628,000 | 2.50% | ||
| 11 | Belmont Global Advisors, Inc. | 171,600 | 3,140,000 | 1.70% | ||
| 12 | D. E. Shaw & Co., Inc. | 166,114 | 3,040,000 | 1.64% | ||
| 13 | Granahan Investment Management, LLC | 141,647 | 2,592,000 | 1.40% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 124,928 | 2,286,000 | 1.24% | ||
| 15 | Informed Momentum Co LLC | 97,003 | 1,775,000 | 0.96% | ||
| 16 | MORGAN STANLEY | 89,330 | 1,635,000 | 0.88% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,953 | 1,244,000 | 0.67% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 59,795 | 1,093,000 | 0.59% | ||
| 19 | HOLLENCREST CAPITAL MANAGEMENT | 45,000 | 824,000 | 0.45% | ||
| 20 | DEUTSCHE BANK AG\ | 40,000 | 732,000 | 0.40% | ||
| 21 | P.A.W. CAPITAL CORP | 40,000 | 732,000 | 0.40% | ||
| 22 | BlackRock Fund Advisors | 30,362 | 556,000 | 0.30% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,100 | 423,000 | 0.23% | Put | |
| 24 | PANAGORA ASSET MANAGEMENT INC | 22,879 | 419,000 | 0.23% | ||
| 25 | NORTHERN TRUST CORP | 22,125 | 405,000 | 0.22% | ||
| 26 | A.R.T. Advisors, LLC | 19,557 | 357,000 | 0.19% | ||
| 27 | NATIONAL PLANNING CORP | 18,250 | 342,000 | 0.18% | ||
| 28 | GOLDMAN SACHS GROUP INC | 16,052 | 294,000 | 0.16% | ||
| 29 | Trellus Management Company, LLC | 12,252 | 224,000 | 0.12% | ||
| 30 | Virtu KCG Holdings LLC | 10,957 | 201,000 | 0.11% | ||
| 31 | UBS Group AG | 3,291 | 61,000 | 0.03% | ||
| 32 | ROYAL BANK OF CANADA | 2,500 | 46,000 | 0.02% | ||
| 33 | BlackRock Investment Management, LLC | 2,038 | 37,000 | 0.02% | ||
| 34 | SIMPLEX TRADING, LLC | 1,413 | 25,000 | 0.01% | ||
| 35 | BLACKROCK ADVISORS LLC | 1,280 | 23,000 | 0.01% | ||
| 36 | WELLS FARGO & COMPANY/MN | 1,114 | 20,000 | 0.01% | ||
| 37 | WFG Advisors, LP | 620 | 11,000 | 0.01% | ||
| 38 | BRAVE ASSET MANAGEMENT INC | 600 | 11,000 | 0.01% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 200 | 3,660 | 0.00% | ||
| 40 | Tower Research Capital LLC (TRC) | 24 | 0 | 0.00% | ||
| 41 | CITIGROUP INC | 18 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
