| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 2,914,970 | 81,007,000 | 17.92% | ||
| 2 | FMR LLC | 2,670,126 | 74,203,000 | 16.42% | ||
| 3 | Broadfin Capital, LLC | 1,095,373 | 30,440,000 | 6.74% | ||
| 4 | RTW INVESTMENTS, LP | 1,080,331 | 30,022,000 | 6.64% | ||
| 5 | FRANKLIN RESOURCES INC | 911,900 | 25,342,000 | 5.61% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 855,572 | 23,776,000 | 5.26% | ||
| 7 | Avoro Capital Advisors LLC | 804,299 | 22,351,000 | 4.95% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 654,515 | 18,189,000 | 4.02% | ||
| 9 | Visium Asset Management, LP | 630,000 | 17,508,000 | 3.87% | ||
| 10 | Allianz Asset Management GmbH | 467,797 | 13,000,000 | 2.88% | ||
| 11 | VANGUARD GROUP INC | 432,202 | 12,011,000 | 2.66% | ||
| 12 | BAKER BROS. ADVISORS LP | 412,008 | 11,450,000 | 2.53% | ||
| 13 | BlackRock Fund Advisors | 356,429 | 9,905,000 | 2.19% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 314,091 | 8,729,000 | 1.93% | ||
| 15 | MORGAN STANLEY | 299,212 | 8,316,000 | 1.84% | ||
| 16 | Granahan Investment Management, LLC | 212,348 | 5,901,000 | 1.31% | ||
| 17 | STATE STREET CORP | 169,152 | 4,699,000 | 1.04% | ||
| 18 | DEUTSCHE BANK AG\ | 145,303 | 4,035,000 | 0.89% | ||
| 19 | NORTHERN TRUST CORP | 141,219 | 3,925,000 | 0.87% | ||
| 20 | Iguana Healthcare Management, LLC | 125,000 | 3,474,000 | 0.77% | ||
| 21 | ACUTA CAPITAL PARTNERS, LLC | 122,222 | 3,397,000 | 0.75% | ||
| 22 | Informed Momentum Co LLC | 97,350 | 2,705,000 | 0.60% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 94,069 | 2,613,000 | 0.58% | ||
| 24 | Asset Management One Co., Ltd. | 91,823 | 2,363,000 | 0.52% | ||
| 25 | SABBY MANAGEMENT, LLC | 85,011 | 2,362,000 | 0.52% | ||
| 26 | CITADEL ADVISORS LLC | 68,910 | 1,915,000 | 0.42% | ||
| 27 | GOLDMAN SACHS GROUP INC | 68,700 | 1,909,000 | 0.42% | Call | |
| 28 | DEERFIELD MANAGEMENT COMPANY, L.P. | 65,000 | 1,806,000 | 0.40% | ||
| 29 | Bank of New York Mellon Corp | 64,156 | 1,783,000 | 0.39% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,900 | 1,720,000 | 0.38% | Call | |
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,300 | 1,509,000 | 0.33% | Put | |
| 32 | P.A.W. CAPITAL CORP | 48,000 | 1,334,000 | 0.30% | ||
| 33 | Lombard Odier Asset Management (USA) Corp | 47,684 | 1,325,000 | 0.29% | ||
| 34 | CREDIT SUISSE AG/ | 47,530 | 1,321,000 | 0.29% | ||
| 35 | BlackRock Investment Management, LLC | 47,469 | 1,319,000 | 0.29% | ||
| 36 | HOLLENCREST CAPITAL MANAGEMENT | 45,000 | 1,251,000 | 0.28% | ||
| 37 | Catalyst Capital Advisors LLC | 45,000 | 1,251,000 | 0.28% | ||
| 38 | AMERIPRISE FINANCIAL INC | 43,873 | 1,219,000 | 0.27% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,401 | 1,095,000 | 0.24% | ||
| 40 | Belmont Global Advisors, Inc. | 35,000 | 973,000 | 0.22% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,102 | 698,000 | 0.15% | ||
| 42 | RENAISSANCE TECHNOLOGIES LLC | 24,898 | 692,000 | 0.15% | ||
| 43 | NATIONAL PLANNING CORP | 18,650 | 533,000 | 0.12% | ||
| 44 | TEACHERS ADVISORS, LLC | 16,817 | 467,000 | 0.10% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,579 | 461,000 | 0.10% | ||
| 46 | RUSSELL FRANK CO/ | 14,312 | 398,000 | 0.09% | ||
| 47 | Advisors Asset Management, Inc. | 13,691 | 380,000 | 0.08% | ||
| 48 | GROUP ONE TRADING LLC | 13,188 | 366,000 | 0.08% | ||
| 49 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 11,900 | 331,000 | 0.07% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 11,500 | 320,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
