| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,052,130 | 48,834,000 | 18.99% | ||
| 2 | FMR LLC | 2,620,326 | 41,925,000 | 16.30% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,332,815 | 21,325,000 | 8.29% | ||
| 4 | Broadfin Capital, LLC | 1,281,373 | 20,502,000 | 7.97% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 1,243,742 | 19,899,000 | 7.74% | ||
| 6 | RTW INVESTMENTS, LP | 1,176,146 | 18,818,000 | 7.32% | ||
| 7 | FRANKLIN RESOURCES INC | 965,600 | 15,450,000 | 6.01% | ||
| 8 | Allianz Asset Management GmbH | 566,890 | 9,070,000 | 3.53% | ||
| 9 | VANGUARD GROUP INC | 484,062 | 7,745,000 | 3.01% | ||
| 10 | BlackRock Fund Advisors | 361,343 | 5,781,000 | 2.25% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 347,644 | 5,562,000 | 2.16% | ||
| 12 | JENNISON ASSOCIATES LLC | 252,437 | 4,039,000 | 1.57% | ||
| 13 | Granahan Investment Management, LLC | 214,229 | 3,428,000 | 1.33% | ||
| 14 | STATE STREET CORP | 211,786 | 3,387,000 | 1.32% | ||
| 15 | SABBY MANAGEMENT, LLC | 206,131 | 3,298,000 | 1.28% | ||
| 16 | NORTHERN TRUST CORP | 189,583 | 3,034,000 | 1.18% | ||
| 17 | Asset Management One Co., Ltd. | 142,696 | 2,371,000 | 0.92% | ||
| 18 | MORGAN STANLEY | 138,661 | 2,219,000 | 0.86% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 96,199 | 1,539,000 | 0.60% | ||
| 20 | Avoro Capital Advisors LLC | 70,000 | 1,120,000 | 0.44% | ||
| 21 | Bank of New York Mellon Corp | 67,369 | 1,077,000 | 0.42% | ||
| 22 | Belmont Global Advisors, Inc. | 60,000 | 960,000 | 0.37% | ||
| 23 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 53,254 | 852,000 | 0.33% | ||
| 24 | BlackRock Investment Management, LLC | 52,724 | 844,000 | 0.33% | ||
| 25 | P.A.W. CAPITAL CORP | 50,000 | 800,000 | 0.31% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,300 | 789,000 | 0.31% | Call | |
| 27 | Advisors Asset Management, Inc. | 46,476 | 744,000 | 0.29% | ||
| 28 | GSA CAPITAL PARTNERS LLP | 44,900 | 718,000 | 0.28% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 43,053 | 689,000 | 0.27% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,000 | 688,000 | 0.27% | Put | |
| 31 | OXFORD ASSET MANAGEMENT LLP | 40,385 | 646,000 | 0.25% | ||
| 32 | SECOR Capital Advisors, LP | 37,992 | 608,000 | 0.24% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 37,300 | 597,000 | 0.23% | ||
| 34 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 36,400 | 582,000 | 0.23% | ||
| 35 | ANALYTIC INVESTORS, LLC | 33,633 | 538,000 | 0.21% | ||
| 36 | DEUTSCHE BANK AG\ | 33,327 | 533,000 | 0.21% | ||
| 37 | CREDIT SUISSE AG/ | 32,741 | 524,000 | 0.20% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,195 | 467,000 | 0.18% | ||
| 39 | Swiss National Bank | 24,400 | 390,000 | 0.15% | ||
| 40 | TEACHERS ADVISORS, LLC | 23,042 | 369,000 | 0.14% | ||
| 41 | HOLLENCREST CAPITAL MANAGEMENT | 22,092 | 353,000 | 0.14% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,579 | 346,000 | 0.13% | ||
| 43 | NATIONAL PLANNING CORP | 17,525 | 314,000 | 0.12% | ||
| 44 | WELLS FARGO & COMPANY/MN | 18,160 | 290,000 | 0.11% | ||
| 45 | VIRTUS ETF ADVISERS LLC | 14,291 | 229,000 | 0.09% | ||
| 46 | Virtu KCG Holdings LLC | 13,898 | 222,000 | 0.09% | ||
| 47 | BAKER BROS. ADVISORS LP | 13,746 | 220,000 | 0.09% | ||
| 48 | RHUMBLINE ADVISERS | 13,595 | 218,000 | 0.08% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 13,600 | 218,000 | 0.08% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 13,341 | 213,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
