| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,440,419 | 102,421,000 | 13.99% | ||
| 2 | FMR LLC | 3,313,318 | 98,637,000 | 13.47% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,157,011 | 64,214,000 | 8.77% | ||
| 4 | JENNISON ASSOCIATES LLC | 2,053,467 | 61,132,000 | 8.35% | ||
| 5 | Consonance Capital Management LP | 2,012,519 | 59,913,000 | 8.18% | ||
| 6 | Broadfin Capital, LLC | 1,257,887 | 37,447,000 | 5.11% | ||
| 7 | STATE STREET CORP | 1,180,368 | 35,140,000 | 4.80% | ||
| 8 | RTW INVESTMENTS, LP | 1,107,379 | 32,967,000 | 4.50% | ||
| 9 | BlackRock Finance, Inc. | 1,098,039 | 32,688,000 | 4.46% | ||
| 10 | JANUS HENDERSON GROUP PLC | 846,182 | 25,191,000 | 3.44% | ||
| 11 | VANGUARD GROUP INC | 816,779 | 24,316,000 | 3.32% | ||
| 12 | Redmile Group, LLC | 713,280 | 21,234,000 | 2.90% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 589,959 | 17,563,000 | 2.40% | ||
| 14 | BAKER BROS. ADVISORS LP | 504,732 | 15,026,000 | 2.05% | ||
| 15 | Allianz Asset Management GmbH | 321,330 | 9,704,000 | 1.33% | ||
| 16 | CITADEL ADVISORS LLC | 299,290 | 8,910,000 | 1.22% | ||
| 17 | BOXER CAPITAL, LLC | 267,500 | 7,963,000 | 1.09% | ||
| 18 | NORTHERN TRUST CORP | 256,640 | 7,641,000 | 1.04% | ||
| 19 | Broadfin Capital, LLC | 150,000 | 4,466,000 | 0.61% | Call | |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 140,362 | 4,178,000 | 0.57% | ||
| 21 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 3,721,000 | 0.51% | ||
| 22 | Quantitative Investment Management, LLC | 121,800 | 3,625,000 | 0.49% | ||
| 23 | DRIEHAUS CAPITAL MANAGEMENT LLC | 121,051 | 3,604,000 | 0.49% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,800 | 3,388,000 | 0.46% | Call | |
| 25 | Bank of New York Mellon Corp | 82,847 | 2,466,000 | 0.34% | ||
| 26 | Alyeska Investment Group, L.P. | 80,583 | 2,399,000 | 0.33% | ||
| 27 | DEUTSCHE BANK AG\ | 78,607 | 2,339,000 | 0.32% | ||
| 28 | MORGAN STANLEY | 74,232 | 2,210,000 | 0.30% | ||
| 29 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 72,000 | 2,143,000 | 0.29% | ||
| 30 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 70,150 | 2,088,000 | 0.29% | ||
| 31 | D. E. Shaw & Co., Inc. | 62,680 | 1,866,000 | 0.25% | ||
| 32 | AXIOM INVESTORS LLC /DE | 55,309 | 1,647,000 | 0.22% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,500 | 1,503,000 | 0.21% | Put | |
| 34 | EMORY UNIVERSITY | 47,353 | 1,410,000 | 0.19% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,043 | 1,400,000 | 0.19% | ||
| 36 | CITIGROUP INC | 44,077 | 1,313,000 | 0.18% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 42,300 | 1,259,000 | 0.17% | ||
| 38 | COWEN INC. | 37,500 | 1,116,000 | 0.15% | Call | |
| 39 | GOLDMAN SACHS GROUP INC | 36,000 | 1,072,000 | 0.15% | Put | |
| 40 | GOLDMAN SACHS GROUP INC | 36,000 | 1,072,000 | 0.15% | Call | |
| 41 | COWEN INC. | 35,000 | 1,042,000 | 0.14% | Put | |
| 42 | Advisors Asset Management, Inc. | 33,059 | 984,000 | 0.13% | ||
| 43 | CREDIT SUISSE AG/ | 32,100 | 956,000 | 0.13% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,995 | 923,000 | 0.13% | ||
| 45 | TEACHERS ADVISORS, LLC | 30,859 | 919,000 | 0.13% | ||
| 46 | Swiss National Bank | 29,400 | 875,000 | 0.12% | ||
| 47 | UBS Group AG | 28,715 | 855,000 | 0.12% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,079 | 836,000 | 0.11% | ||
| 49 | Informed Momentum Co LLC | 22,230 | 662,000 | 0.09% | ||
| 50 | HOLLENCREST CAPITAL MANAGEMENT | 22,092 | 658,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
