| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 23,366,007 | 76,874,000 | 27.22% | ||
| 2 | QVT Financial LP | 10,816,953 | 35,588,000 | 12.60% | ||
| 3 | STATE STREET CORP | 6,885,429 | 22,655,000 | 8.02% | ||
| 4 | VANGUARD GROUP INC | 5,118,926 | 16,842,000 | 5.96% | ||
| 5 | Capital World Investors | 4,130,000 | 13,588,000 | 4.81% | ||
| 6 | BlackRock Fund Advisors | 3,620,099 | 11,910,000 | 4.22% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 3,148,196 | 10,358,000 | 3.67% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 3,000,000 | 9,870,000 | 3.49% | Call | |
| 9 | GOLDMAN SACHS GROUP INC | 2,850,000 | 9,377,000 | 3.32% | Call | |
| 10 | GOLDMAN SACHS GROUP INC | 2,410,132 | 7,930,000 | 2.81% | ||
| 11 | STATE OF WISCONSIN INVESTMENT BOARD | 2,209,440 | 7,269,000 | 2.57% | ||
| 12 | BB BIOTECH AG | 1,779,340 | 5,854,000 | 2.07% | ||
| 13 | NORTHERN TRUST CORP | 1,251,152 | 4,117,000 | 1.46% | ||
| 14 | DOHENY ASSET MANAGEMENT /CA | 1,122,325 | 3,692,000 | 1.31% | ||
| 15 | Broadfin Capital, LLC | 1,000,000 | 3,290,000 | 1.16% | ||
| 16 | FMR LLC | 885,200 | 2,912,000 | 1.03% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 870,009 | 2,862,000 | 1.01% | ||
| 18 | AQR CAPITAL MANAGEMENT LLC | 700,600 | 2,305,000 | 0.82% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 636,400 | 2,094,000 | 0.74% | Call | |
| 20 | MORGAN STANLEY | 609,801 | 2,006,000 | 0.71% | ||
| 21 | DEUTSCHE BANK AG\ | 519,152 | 1,707,000 | 0.60% | ||
| 22 | ROYCE & ASSOCIATES LP | 500,000 | 1,645,000 | 0.58% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 463,100 | 1,524,000 | 0.54% | Put | |
| 24 | GROUP ONE TRADING LLC | 458,974 | 1,510,000 | 0.53% | ||
| 25 | Bank of New York Mellon Corp | 458,886 | 1,510,000 | 0.53% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 450,043 | 1,480,000 | 0.52% | ||
| 27 | BAKER BROS. ADVISORS LP | 438,337 | 1,442,000 | 0.51% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 405,954 | 1,336,000 | 0.47% | ||
| 29 | BLACKROCK ADVISORS LLC | 404,207 | 1,330,000 | 0.47% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 395,267 | 1,301,000 | 0.46% | ||
| 31 | Allianz Asset Management GmbH | 384,300 | 1,264,000 | 0.45% | ||
| 32 | BlackRock Investment Management, LLC | 269,334 | 886,000 | 0.31% | ||
| 33 | HAP Trading, LLC | 262,773 | 865,000 | 0.31% | ||
| 34 | WELLS FARGO & COMPANY/MN | 239,349 | 787,000 | 0.28% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 215,686 | 710,000 | 0.25% | ||
| 36 | Index Management Solutions, LLC | 201,548 | 663,000 | 0.23% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 174,507 | 574,000 | 0.20% | ||
| 38 | ProShare Advisors LLC | 171,762 | 565,000 | 0.20% | ||
| 39 | WESTFIELD CAPITAL MANAGEMENT CO LP | 161,300 | 531,000 | 0.19% | ||
| 40 | TEACHERS ADVISORS, LLC | 149,803 | 493,000 | 0.17% | ||
| 41 | DIMENSIONAL FUND ADVISORS LP | 147,342 | 485,000 | 0.17% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 147,200 | 484,000 | 0.17% | ||
| 43 | RAYMOND JAMES & ASSOCIATES | 146,000 | 480,000 | 0.17% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 118,400 | 361,000 | 0.13% | ||
| 45 | CREDIT SUISSE AG/ | 95,616 | 315,000 | 0.11% | ||
| 46 | DEERFIELD MANAGEMENT COMPANY, L.P. | 92,804 | 305,000 | 0.11% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 88,944 | 293,000 | 0.10% | ||
| 48 | BARCLAYS PLC | 90,922 | 272,000 | 0.10% | ||
| 49 | INTEGRAL DERIVATIVES, LLC | 81,900 | 269,000 | 0.10% | Call | |
| 50 | D. E. Shaw & Co., Inc. | 81,000 | 266,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
