| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 11,733,815 | 81,081,000 | 9.29% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 10,876,836 | 75,160,000 | 8.61% | ||
| 3 | Point72 Asset Management, L.P. | 9,772,018 | 67,525,000 | 7.73% | ||
| 4 | FMR LLC | 8,869,972 | 61,292,000 | 7.02% | ||
| 5 | VANGUARD GROUP INC | 7,371,139 | 50,934,000 | 5.83% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 7,334,548 | 50,682,000 | 5.80% | ||
| 7 | ORBIMED ADVISORS LLC | 5,222,500 | 36,087,000 | 4.13% | ||
| 8 | STATE STREET CORP | 5,000,529 | 34,551,000 | 3.96% | ||
| 9 | BlackRock Fund Advisors | 4,723,459 | 32,639,000 | 3.74% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,048,219 | 27,973,000 | 3.20% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,826,073 | 19,528,000 | 2.24% | ||
| 12 | RTW INVESTMENTS, LP | 2,589,818 | 17,896,000 | 2.05% | ||
| 13 | EverPoint Asset Management, LLC | 2,500,000 | 17,275,000 | 1.98% | ||
| 14 | GOLDMAN SACHS GROUP INC | 2,270,428 | 15,688,000 | 1.80% | ||
| 15 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 2,045,256 | 14,133,000 | 1.62% | ||
| 16 | BAKER BROS. ADVISORS LP | 2,000,000 | 13,820,000 | 1.58% | ||
| 17 | ALPS ADVISORS INC | 184,008 | 12,715,000 | 1.46% | ||
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,667,000 | 11,519,000 | 1.32% | ||
| 19 | GOLDMAN SACHS GROUP INC | 1,584,000 | 10,945,000 | 1.25% | Call | |
| 20 | NORTHERN TRUST CORP | 1,367,822 | 9,452,000 | 1.08% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,366,400 | 9,442,000 | 1.08% | Put | |
| 22 | BB BIOTECH AG | 1,279,340 | 8,840,000 | 1.01% | ||
| 23 | Rock Springs Capital Management LP | 1,125,000 | 7,774,000 | 0.89% | ||
| 24 | JPMORGAN CHASE & CO | 1,121,293 | 7,747,000 | 0.89% | ||
| 25 | TURNER INVESTMENTS LLC | 1,086,000 | 7,504,000 | 0.86% | ||
| 26 | AXA S.A. | 1,017,206 | 7,029,000 | 0.81% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 993,100 | 6,862,000 | 0.79% | Call | |
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 964,147 | 6,662,000 | 0.76% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 888,485 | 6,139,000 | 0.70% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 823,189 | 5,688,000 | 0.65% | ||
| 31 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,700 | 5,533,000 | 0.63% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 721,274 | 4,984,000 | 0.57% | ||
| 33 | MARSHALL WACE, LLP | 709,855 | 4,905,000 | 0.56% | ||
| 34 | DEUTSCHE BANK AG\ | 707,104 | 4,884,000 | 0.56% | ||
| 35 | South Dakota Investment Council | 690,300 | 4,770,000 | 0.55% | ||
| 36 | CITADEL ADVISORS LLC | 671,826 | 4,642,000 | 0.53% | ||
| 37 | Asset Management One Co., Ltd. | 682,633 | 4,478,000 | 0.51% | ||
| 38 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 646,159 | 4,465,000 | 0.51% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 637,988 | 4,408,000 | 0.50% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 633,998 | 4,381,000 | 0.50% | ||
| 41 | SENZAR ASSET MANAGEMENT, LLC | 619,000 | 4,277,290 | 0.49% | ||
| 42 | Tekla Capital Management LLC | 547,300 | 3,782,000 | 0.43% | ||
| 43 | Bank of New York Mellon Corp | 545,037 | 3,766,000 | 0.43% | ||
| 44 | DOHENY ASSET MANAGEMENT /CA | 510,125 | 3,525,000 | 0.40% | ||
| 45 | TEACHERS ADVISORS, LLC | 492,302 | 3,402,000 | 0.39% | ||
| 46 | DAFNA Capital Management LLC | 480,300 | 3,319,000 | 0.38% | SH | |
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 478,105 | 3,304,000 | 0.38% | ||
| 48 | COLUMBUS CIRCLE INVESTORS | 427,789 | 2,956,000 | 0.34% | ||
| 49 | BELLEVUE ASSET MANAGEMENT AG | 420,000 | 2,902,000 | 0.33% | ||
| 50 | A.R.T. Advisors, LLC | 394,723 | 2,727,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
