| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 11,222,893 | 121,095,000 | 9.40% | ||
| 2 | ORBIMED ADVISORS LLC | 9,649,900 | 104,122,000 | 8.08% | ||
| 3 | Point72 Asset Management, L.P. | 8,966,608 | 96,750,000 | 7.51% | ||
| 4 | FMR LLC | 8,869,972 | 95,707,000 | 7.43% | ||
| 5 | VANGUARD GROUP INC | 7,682,621 | 82,896,000 | 6.43% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 7,017,465 | 75,718,000 | 5.88% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 4,880,327 | 52,659,000 | 4.09% | ||
| 8 | BlackRock Fund Advisors | 4,471,134 | 48,244,000 | 3.74% | ||
| 9 | STATE STREET CORP | 4,144,011 | 44,714,000 | 3.47% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,060,119 | 43,809,000 | 3.40% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 3,229,711 | 34,848,000 | 2.71% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,915,843 | 31,462,000 | 2.44% | ||
| 13 | GOLDMAN SACHS GROUP INC | 2,628,448 | 28,361,000 | 2.20% | ||
| 14 | BAKER BROS. ADVISORS LP | 2,000,000 | 21,580,000 | 1.68% | ||
| 15 | RTW INVESTMENTS, LP | 1,951,922 | 21,061,000 | 1.63% | ||
| 16 | GOLDMAN SACHS GROUP INC | 1,715,200 | 18,507,000 | 1.44% | Call | |
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,667,000 | 17,987,000 | 1.40% | ||
| 18 | EverPoint Asset Management, LLC | 1,600,000 | 17,264,000 | 1.34% | ||
| 19 | DEUTSCHE BANK AG\ | 1,416,827 | 15,284,000 | 1.19% | ||
| 20 | NORTHERN TRUST CORP | 1,365,563 | 14,735,000 | 1.14% | ||
| 21 | BB BIOTECH AG | 1,279,340 | 13,804,000 | 1.07% | ||
| 22 | Connor, Clark & Lunn Investment Management Ltd. | 1,271,047 | 13,715,000 | 1.06% | ||
| 23 | Invesco Ltd. | 1,126,449 | 12,154,000 | 0.94% | ||
| 24 | JPMORGAN CHASE & CO | 1,106,973 | 11,944,000 | 0.93% | ||
| 25 | Rock Springs Capital Management LP | 1,105,000 | 11,923,000 | 0.93% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,087,300 | 11,732,000 | 0.91% | Put | |
| 27 | AXA S.A. | 986,643 | 10,646,000 | 0.83% | ||
| 28 | MARSHALL WACE, LLP | 970,862 | 10,476,000 | 0.81% | ||
| 29 | TURNER INVESTMENTS LLC | 911,010 | 9,830,000 | 0.76% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 849,179 | 9,170,000 | 0.71% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 767,495 | 8,281,000 | 0.64% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 734,800 | 7,928,000 | 0.62% | Call | |
| 33 | Asset Management One Co., Ltd. | 698,755 | 7,281,000 | 0.57% | ||
| 34 | AMERICAN CENTURY COMPANIES INC | 668,918 | 7,218,000 | 0.56% | ||
| 35 | South Dakota Investment Council | 667,400 | 7,201,000 | 0.56% | ||
| 36 | Ghost Tree Capital, LLC | 600,000 | 6,474,000 | 0.50% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 597,536 | 6,447,000 | 0.50% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 579,919 | 6,257,000 | 0.49% | ||
| 39 | Bank of New York Mellon Corp | 561,430 | 6,057,000 | 0.47% | ||
| 40 | CITADEL ADVISORS LLC | 531,580 | 5,736,000 | 0.45% | ||
| 41 | Cormorant Asset Management, LP | 500,000 | 5,395,000 | 0.42% | ||
| 42 | DOHENY ASSET MANAGEMENT /CA | 460,550 | 4,969,000 | 0.39% | ||
| 43 | UBS Group AG | 431,337 | 4,655,000 | 0.36% | ||
| 44 | BELLEVUE ASSET MANAGEMENT AG | 420,000 | 4,532,000 | 0.35% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 415,839 | 4,487,000 | 0.35% | ||
| 46 | BlackRock Investment Management, LLC | 395,273 | 4,265,000 | 0.33% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 383,095 | 4,134,000 | 0.32% | ||
| 48 | Candriam S.C.A. | 344,300 | 3,715,000 | 0.29% | ||
| 49 | TFS CAPITAL LLC | 300,116 | 3,238,000 | 0.25% | ||
| 50 | Rhenman & Partners Asset Management AB | 266,000 | 2,870,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
