| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 12,033,220 | 93,859,000 | 10.91% | ||
| 2 | ORBIMED ADVISORS LLC | 11,681,600 | 91,116,000 | 10.59% | ||
| 3 | Point72 Asset Management, L.P. | 8,987,615 | 70,103,000 | 8.15% | ||
| 4 | VANGUARD GROUP INC | 8,454,713 | 65,947,000 | 7.67% | ||
| 5 | FMR LLC | 7,704,406 | 60,094,000 | 6.99% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 5,712,359 | 44,555,000 | 5.18% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,866,919 | 37,962,000 | 4.41% | ||
| 8 | BlackRock Fund Advisors | 4,531,181 | 35,343,000 | 4.11% | ||
| 9 | GOLDMAN SACHS GROUP INC | 3,978,735 | 31,034,000 | 3.61% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 3,228,635 | 25,183,000 | 2.93% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,021,403 | 23,567,000 | 2.74% | ||
| 12 | STATE STREET CORP | 3,008,555 | 23,469,000 | 2.73% | ||
| 13 | BAKER BROS. ADVISORS LP | 2,475,515 | 19,309,000 | 2.24% | ||
| 14 | RTW INVESTMENTS, LP | 2,424,136 | 18,908,000 | 2.20% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 1,778,333 | 13,871,000 | 1.61% | ||
| 16 | DEUTSCHE BANK AG\ | 1,487,623 | 11,600,000 | 1.35% | ||
| 17 | NORTHERN TRUST CORP | 1,459,960 | 11,388,000 | 1.32% | ||
| 18 | Rock Springs Capital Management LP | 1,312,500 | 10,238,000 | 1.19% | ||
| 19 | BB BIOTECH AG | 1,279,340 | 9,979,000 | 1.16% | ||
| 20 | Cormorant Asset Management, LP | 1,006,128 | 7,848,000 | 0.91% | ||
| 21 | AXA S.A. | 932,784 | 7,276,000 | 0.85% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 880,254 | 6,865,000 | 0.80% | ||
| 23 | AMERICAN CENTURY COMPANIES INC | 870,293 | 6,788,000 | 0.79% | ||
| 24 | TURNER INVESTMENTS LLC | 855,570 | 6,674,000 | 0.78% | ||
| 25 | Connor, Clark & Lunn Investment Management Ltd. | 843,947 | 6,583,000 | 0.77% | ||
| 26 | Invesco Ltd. | 776,193 | 6,054,000 | 0.70% | ||
| 27 | NORGES BANK | 763,819 | 5,958,000 | 0.69% | ||
| 28 | JPMORGAN CHASE & CO | 734,239 | 5,726,000 | 0.67% | ||
| 29 | South Dakota Investment Council | 670,600 | 5,231,000 | 0.61% | ||
| 30 | Asset Management One Co., Ltd. | 579,409 | 4,542,000 | 0.53% | ||
| 31 | Bank of New York Mellon Corp | 541,551 | 4,224,000 | 0.49% | ||
| 32 | MARSHALL WACE, LLP | 540,611 | 4,217,000 | 0.49% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 500,417 | 3,903,000 | 0.45% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 482,512 | 3,764,000 | 0.44% | ||
| 35 | BlackRock Investment Management, LLC | 437,200 | 3,410,000 | 0.40% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 426,300 | 3,325,000 | 0.39% | Call | |
| 37 | BELLEVUE GROUP AG | 420,000 | 3,276,000 | 0.38% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 419,370 | 3,272,000 | 0.38% | ||
| 39 | PDT Partners, LLC | 285,600 | 2,228,000 | 0.26% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 278,221 | 2,170,000 | 0.25% | ||
| 41 | QS Investors, LLC | 277,552 | 2,165,000 | 0.25% | ||
| 42 | Rhenman & Partners Asset Management AB | 266,000 | 2,075,000 | 0.24% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 246,060 | 1,919,000 | 0.22% | ||
| 44 | DAFNA Capital Management LLC | 236,500 | 1,845,000 | 0.21% | SH | |
| 45 | CREDIT SUISSE AG/ | 203,870 | 1,590,000 | 0.18% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 200,200 | 1,562,000 | 0.18% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 198,200 | 1,546,000 | 0.18% | Put | |
| 48 | UBS Group AG | 193,371 | 1,508,000 | 0.18% | ||
| 49 | ALPS ADVISORS INC | 191,953 | 1,497,000 | 0.17% | ||
| 50 | Gotham Asset Management, LLC | 191,792 | 1,496,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
