| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 12,033,220 | 92,896,000 | 10.59% | ||
| 2 | ORBIMED ADVISORS LLC | 11,519,700 | 88,932,000 | 10.14% | ||
| 3 | Point72 Asset Management, L.P. | 9,103,921 | 70,282,000 | 8.01% | ||
| 4 | FMR LLC | 8,053,872 | 62,176,000 | 7.09% | ||
| 5 | VANGUARD GROUP INC | 7,999,462 | 61,756,000 | 7.04% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 6,779,004 | 52,336,000 | 5.97% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,795,207 | 37,019,000 | 4.22% | ||
| 8 | BlackRock Fund Advisors | 4,573,313 | 35,306,000 | 4.02% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 3,897,065 | 30,085,000 | 3.43% | ||
| 10 | STATE STREET CORP | 3,727,667 | 28,778,000 | 3.28% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,885,145 | 22,273,000 | 2.54% | ||
| 12 | GOLDMAN SACHS GROUP INC | 2,590,494 | 19,999,000 | 2.28% | ||
| 13 | RTW INVESTMENTS, LP | 2,558,859 | 19,754,000 | 2.25% | ||
| 14 | BAKER BROS. ADVISORS LP | 2,475,515 | 19,111,000 | 2.18% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 2,197,161 | 16,962,000 | 1.93% | ||
| 16 | NORTHERN TRUST CORP | 1,381,467 | 10,666,000 | 1.22% | ||
| 17 | DEUTSCHE BANK AG\ | 1,366,854 | 10,550,000 | 1.20% | ||
| 18 | BB BIOTECH AG | 1,279,340 | 9,877,000 | 1.13% | ||
| 19 | Rock Springs Capital Management LP | 1,220,000 | 9,418,000 | 1.07% | ||
| 20 | Connor, Clark & Lunn Investment Management Ltd. | 1,086,447 | 8,387,000 | 0.96% | ||
| 21 | JPMORGAN CHASE & CO | 1,062,755 | 8,206,000 | 0.94% | ||
| 22 | Invesco Ltd. | 1,037,451 | 8,009,000 | 0.91% | ||
| 23 | AXA S.A. | 970,957 | 7,496,000 | 0.85% | ||
| 24 | MARSHALL WACE, LLP | 902,202 | 6,965,000 | 0.79% | ||
| 25 | TURNER INVESTMENTS LLC | 859,560 | 6,636,000 | 0.76% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 811,772 | 6,267,000 | 0.71% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 797,518 | 6,156,000 | 0.70% | ||
| 28 | South Dakota Investment Council | 711,500 | 5,493,000 | 0.63% | ||
| 29 | Asset Management One Co., Ltd. | 698,585 | 5,253,000 | 0.60% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 608,481 | 4,697,000 | 0.54% | ||
| 31 | Gotham Asset Management, LLC | 554,125 | 4,278,000 | 0.49% | ||
| 32 | Bank of New York Mellon Corp | 541,292 | 4,179,000 | 0.48% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 524,991 | 4,053,000 | 0.46% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 504,700 | 3,896,000 | 0.44% | Call | |
| 35 | Cormorant Asset Management, LP | 500,000 | 3,860,000 | 0.44% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 496,298 | 3,831,000 | 0.44% | ||
| 37 | BELLEVUE GROUP AG | 420,000 | 3,242,000 | 0.37% | ||
| 38 | BlackRock Investment Management, LLC | 403,580 | 3,116,000 | 0.36% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 400,000 | 3,088,000 | 0.35% | Call | |
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 391,106 | 3,020,000 | 0.34% | ||
| 41 | CITADEL ADVISORS LLC | 344,087 | 2,656,000 | 0.30% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 329,041 | 2,540,000 | 0.29% | ||
| 43 | PDT Partners, LLC | 284,900 | 2,199,000 | 0.25% | ||
| 44 | Candriam S.C.A. | 285,000 | 2,188,000 | 0.25% | ||
| 45 | QS Investors, LLC | 277,552 | 2,143,000 | 0.24% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 270,900 | 2,091,000 | 0.24% | Put | |
| 47 | Rhenman & Partners Asset Management AB | 266,000 | 2,054,000 | 0.23% | ||
| 48 | Ghost Tree Capital, LLC | 250,000 | 1,930,000 | 0.22% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 249,060 | 1,923,000 | 0.22% | ||
| 50 | DAFNA Capital Management LLC | 236,500 | 1,826,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
