| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,833,816 | 132,714,000 | 10.58% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 6,700,000 | 82,075,000 | 6.55% | ||
| 3 | VANGUARD GROUP INC | 5,486,021 | 67,204,000 | 5.36% | ||
| 4 | GOLDMAN SACHS GROUP INC | 5,265,740 | 64,505,000 | 5.14% | ||
| 5 | BlackRock Fund Advisors | 3,851,254 | 47,178,000 | 3.76% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 3,103,369 | 38,016,000 | 3.03% | ||
| 7 | Bain Capital Public Equity Management, LLC | 2,928,750 | 35,877,000 | 2.86% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,920,300 | 35,774,000 | 2.85% | ||
| 9 | STATE STREET CORP | 2,838,903 | 34,781,000 | 2.77% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,768,400 | 33,913,000 | 2.70% | Call | |
| 11 | FRANKLIN RESOURCES INC | 2,603,300 | 31,890,000 | 2.54% | ||
| 12 | Capital World Investors | 2,140,000 | 31,779,000 | 2.53% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 2,531,603 | 31,012,000 | 2.47% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 2,500,000 | 30,625,000 | 2.44% | Call | |
| 15 | SECTORAL ASSET MANAGEMENT INC | 2,373,810 | 29,079,000 | 2.32% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,314,400 | 28,352,000 | 2.26% | Put | |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 2,283,192 | 27,969,000 | 2.23% | ||
| 18 | GOLDMAN SACHS GROUP INC | 2,108,400 | 25,828,000 | 2.06% | Call | |
| 19 | MILLENNIUM MANAGEMENT LLC | 1,735,963 | 21,266,000 | 1.70% | ||
| 20 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,643,430 | 20,132,000 | 1.61% | ||
| 21 | RTW INVESTMENTS, LP | 1,622,633 | 19,877,000 | 1.59% | ||
| 22 | Invesco Ltd. | 1,407,760 | 17,245,000 | 1.38% | ||
| 23 | ProQuest Associates IV LLC | 1,122,957 | 13,757,000 | 1.10% | ||
| 24 | BB BIOTECH AG | 1,079,340 | 13,222,000 | 1.05% | ||
| 25 | NORTHERN TRUST CORP | 1,058,850 | 12,971,000 | 1.03% | ||
| 26 | SABBY MANAGEMENT, LLC | 1,004,187 | 12,301,000 | 0.98% | ||
| 27 | HAP Trading, LLC | 879,642 | 10,776,000 | 0.86% | ||
| 28 | GOLDMAN SACHS GROUP INC | 842,300 | 10,318,000 | 0.82% | Put | |
| 29 | South Dakota Investment Council | 762,400 | 9,339,000 | 0.74% | ||
| 30 | Laurion Capital Management LP | 682,900 | 8,366,000 | 0.67% | ||
| 31 | Bank of New York Mellon Corp | 645,912 | 7,911,000 | 0.63% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 628,259 | 7,696,000 | 0.61% | ||
| 33 | Point72 Asset Management, L.P. | 621,900 | 7,618,000 | 0.61% | ||
| 34 | STIFEL FINANCIAL CORP | 612,167 | 7,499,000 | 0.60% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 554,419 | 6,791,000 | 0.54% | ||
| 36 | DOHENY ASSET MANAGEMENT /CA | 517,450 | 6,339,000 | 0.51% | ||
| 37 | QVT Financial LP | 515,583 | 6,316,000 | 0.50% | ||
| 38 | TEACHERS ADVISORS, LLC | 452,819 | 5,547,000 | 0.44% | ||
| 39 | Asset Management One Co., Ltd. | 426,838 | 5,401,000 | 0.43% | ||
| 40 | BAKER BROS. ADVISORS LP | 438,337 | 5,370,000 | 0.43% | ||
| 41 | OXFORD ASSET MANAGEMENT LLP | 434,453 | 5,331,000 | 0.43% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 431,781 | 5,289,000 | 0.42% | ||
| 43 | DEUTSCHE BANK AG\ | 427,621 | 5,236,000 | 0.42% | ||
| 44 | GILDER GAGNON HOWE & CO LLC | 415,055 | 5,084,000 | 0.41% | ||
| 45 | AXA S.A. | 397,772 | 4,873,000 | 0.39% | ||
| 46 | Jefferies Group LLC | 395,900 | 4,850,000 | 0.39% | Call | |
| 47 | Rhenman & Partners Asset Management AB | 368,000 | 4,508,000 | 0.36% | ||
| 48 | Rock Springs Capital Management LP | 365,000 | 4,471,000 | 0.36% | ||
| 49 | PICTET ASSET MANAGEMENT LTD | 357,952 | 4,385,000 | 0.35% | ||
| 50 | JPMORGAN CHASE & CO | 342,942 | 4,201,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
