| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 13,633,220 | 56,305,000 | 13.60% | ||
| 2 | ORBIMED ADVISORS LLC | 13,107,200 | 54,133,000 | 13.08% | ||
| 3 | VANGUARD GROUP INC | 8,939,408 | 36,920,000 | 8.92% | ||
| 4 | BlackRock Fund Advisors | 5,411,414 | 22,349,000 | 5.40% | ||
| 5 | STATE STREET CORP | 5,121,160 | 21,153,000 | 5.11% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 4,658,845 | 19,243,000 | 4.65% | ||
| 7 | GOLDMAN SACHS GROUP INC | 4,452,042 | 18,387,000 | 4.44% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,867,795 | 15,974,000 | 3.86% | ||
| 9 | Numeric Investors LLC | 2,726,488 | 11,260,000 | 2.72% | ||
| 10 | BVF INC/IL | 2,423,300 | 10,008,000 | 2.42% | ||
| 11 | MORGAN STANLEY | 2,390,832 | 9,874,000 | 2.39% | ||
| 12 | BAKER BROS. ADVISORS LP | 1,856,637 | 7,668,000 | 1.85% | ||
| 13 | DEUTSCHE BANK AG\ | 1,791,322 | 7,396,000 | 1.79% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 1,670,433 | 6,899,000 | 1.67% | ||
| 15 | FMR LLC | 1,521,204 | 6,283,000 | 1.52% | ||
| 16 | NORTHERN TRUST CORP | 1,443,544 | 5,962,000 | 1.44% | ||
| 17 | Rock Springs Capital Management LP | 1,375,000 | 5,679,000 | 1.37% | ||
| 18 | BB BIOTECH AG | 1,279,340 | 5,284,000 | 1.28% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 1,130,923 | 4,671,000 | 1.13% | ||
| 20 | NORGES BANK | 1,119,496 | 4,623,000 | 1.12% | ||
| 21 | Spark Investment Management LLC | 978,600 | 4,041,000 | 0.98% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 945,189 | 3,904,000 | 0.94% | ||
| 23 | TEACHERS ADVISORS, LLC | 943,541 | 3,897,000 | 0.94% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 910,741 | 3,761,000 | 0.91% | ||
| 25 | AXA S.A. | 846,611 | 3,497,000 | 0.84% | ||
| 26 | South Dakota Investment Council | 843,500 | 3,484,000 | 0.84% | ||
| 27 | HBK INVESTMENTS L P | 602,189 | 2,487,000 | 0.60% | ||
| 28 | Bank of New York Mellon Corp | 548,534 | 2,266,000 | 0.55% | ||
| 29 | CITIGROUP INC | 542,613 | 2,242,000 | 0.54% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 536,923 | 2,218,000 | 0.54% | ||
| 31 | EMORY UNIVERSITY | 454,102 | 1,875,000 | 0.45% | ||
| 32 | JPMORGAN CHASE & CO | 448,970 | 1,854,000 | 0.45% | ||
| 33 | Tekla Capital Management LLC | 443,851 | 1,833,000 | 0.44% | ||
| 34 | BlackRock Investment Management, LLC | 435,720 | 1,800,000 | 0.43% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 428,841 | 1,772,000 | 0.43% | ||
| 36 | DIMENSIONAL FUND ADVISORS LP | 405,802 | 1,676,000 | 0.40% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 397,192 | 1,640,000 | 0.40% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 383,676 | 1,585,000 | 0.38% | ||
| 39 | BLACKROCK ADVISORS LLC | 381,089 | 1,574,000 | 0.38% | ||
| 40 | Connor, Clark & Lunn Investment Management Ltd. | 360,849 | 1,490,000 | 0.36% | ||
| 41 | CITADEL ADVISORS LLC | 310,501 | 1,283,000 | 0.31% | ||
| 42 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 292,433 | 1,207,000 | 0.29% | ||
| 43 | RTW INVESTMENTS, LP | 286,285 | 1,182,000 | 0.29% | ||
| 44 | QS Investors, LLC | 277,552 | 1,146,000 | 0.28% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 241,660 | 998,000 | 0.24% | ||
| 46 | BELLEVUE GROUP AG | 240,000 | 991,000 | 0.24% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 225,700 | 932,000 | 0.23% | Call | |
| 48 | GSA CAPITAL PARTNERS LLP | 211,027 | 872,000 | 0.21% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 210,165 | 868,000 | 0.21% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 200,363 | 827,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
