| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 13,633,220 | 62,576,000 | 13.34% | ||
| 2 | ORBIMED ADVISORS LLC | 13,107,200 | 60,162,000 | 12.83% | ||
| 3 | VANGUARD GROUP INC | 9,574,335 | 43,946,000 | 9.37% | ||
| 4 | BlackRock Finance, Inc. | 9,530,142 | 43,744,000 | 9.33% | ||
| 5 | JANUS HENDERSON GROUP PLC | 4,526,817 | 20,778,000 | 4.43% | ||
| 6 | STATE STREET CORP | 3,974,429 | 18,243,000 | 3.89% | ||
| 7 | GOLDMAN SACHS GROUP INC | 3,613,694 | 16,587,000 | 3.54% | ||
| 8 | BVF INC/IL | 3,490,077 | 16,019,000 | 3.42% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 3,016,191 | 13,844,000 | 2.95% | ||
| 10 | Numeric Investors LLC | 2,935,344 | 13,473,000 | 2.87% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 1,868,968 | 8,579,000 | 1.83% | ||
| 12 | BAKER BROS. ADVISORS LP | 1,856,637 | 8,522,000 | 1.82% | ||
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 1,803,902 | 8,280,000 | 1.77% | ||
| 14 | Rock Springs Capital Management LP | 1,725,000 | 7,918,000 | 1.69% | ||
| 15 | FMR LLC | 1,603,622 | 7,361,000 | 1.57% | ||
| 16 | RTW INVESTMENTS, LP | 1,590,454 | 7,300,000 | 1.56% | ||
| 17 | NORTHERN TRUST CORP | 1,426,821 | 6,549,000 | 1.40% | ||
| 18 | TEACHERS ADVISORS, LLC | 1,425,382 | 6,543,000 | 1.39% | ||
| 19 | DEUTSCHE BANK AG\ | 1,305,900 | 5,992,000 | 1.28% | ||
| 20 | BB BIOTECH AG | 1,279,340 | 5,872,000 | 1.25% | ||
| 21 | SENZAR ASSET MANAGEMENT, LLC | 1,082,100 | 4,966,000 | 1.06% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 1,073,029 | 4,925,000 | 1.05% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 850,000 | 3,902,000 | 0.83% | ||
| 24 | JPMORGAN CHASE & CO | 849,336 | 3,897,000 | 0.83% | ||
| 25 | South Dakota Investment Council | 843,500 | 3,872,000 | 0.83% | ||
| 26 | AXA S.A. | 792,206 | 3,636,000 | 0.78% | ||
| 27 | EcoR1 Capital, LLC | 742,835 | 3,410,000 | 0.73% | ||
| 28 | ArrowMark Colorado Holdings LLC | 683,619 | 3,138,000 | 0.67% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 641,300 | 2,944,000 | 0.63% | ||
| 30 | Bank of New York Mellon Corp | 611,634 | 2,808,000 | 0.60% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 482,929 | 2,216,000 | 0.47% | ||
| 32 | NORGES BANK | 470,292 | 2,159,000 | 0.46% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 457,341 | 2,100,000 | 0.45% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 428,933 | 1,969,000 | 0.42% | ||
| 35 | STIFEL FINANCIAL CORP | 403,200 | 1,851,000 | 0.39% | ||
| 36 | GSA CAPITAL PARTNERS LLP | 387,258 | 1,778,000 | 0.38% | ||
| 37 | QS Investors, LLC | 378,570 | 1,738,000 | 0.37% | ||
| 38 | EMORY UNIVERSITY | 372,327 | 1,709,000 | 0.36% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 342,549 | 1,572,000 | 0.34% | ||
| 40 | MORGAN STANLEY | 299,976 | 1,377,000 | 0.29% | ||
| 41 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 273,405 | 1,254,000 | 0.27% | ||
| 42 | DAFNA Capital Management LLC | 266,500 | 1,223,000 | 0.26% | ||
| 43 | 683 Capital Management, LLC | 250,000 | 1,148,000 | 0.24% | ||
| 44 | WELLS FARGO & COMPANY/MN | 219,647 | 1,009,000 | 0.22% | ||
| 45 | PDT Partners, LLC | 216,000 | 991,000 | 0.21% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 207,360 | 952,000 | 0.20% | ||
| 47 | Spark Investment Management LLC | 195,800 | 898,000 | 0.19% | ||
| 48 | CITADEL ADVISORS LLC | 181,969 | 835,000 | 0.18% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 171,200 | 786,000 | 0.17% | ||
| 50 | Rhenman & Partners Asset Management AB | 166,000 | 762,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
