| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
4,387,466 |
108,678,000 |
27.75% |
|
|
| 2 |
Clarus Ventures, LLC |
3,468,495 |
85,915,000 |
21.94% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
2,459,199 |
60,915,000 |
15.56% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,350,850 |
33,461,000 |
8.54% |
|
|
| 5 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
404,100 |
10,009,557 |
2.56% |
|
|
| 6 |
PUTNAM INVESTMENTS LLC |
319,900 |
7,924,000 |
2.02% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
309,374 |
7,664,000 |
1.96% |
|
|
| 8 |
WALL STREET ASSOCIATES |
301,200 |
7,461,000 |
1.91% |
|
|
| 9 |
BAKER BROS. ADVISORS LP |
299,356 |
7,415,000 |
1.89% |
|
|
| 10 |
BlackRock Fund Advisors |
255,321 |
6,324,000 |
1.61% |
|
|
| 11 |
JENNISON ASSOCIATES LLC |
231,387 |
5,731,000 |
1.46% |
|
|
| 12 |
VANGUARD GROUP INC |
193,405 |
4,791,000 |
1.22% |
|
|
| 13 |
CITY NATIONAL BANK |
186,340 |
4,616,000 |
1.18% |
|
|
| 14 |
PERCEPTIVE ADVISORS LLC |
1,121,951 |
4,196,000 |
1.07% |
|
|
| 15 |
Iguana Healthcare Management, LLC |
145,700 |
3,609,000 |
0.92% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
138,079 |
3,420,000 |
0.87% |
|
|
| 17 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
119,045 |
2,949,000 |
0.75% |
|
|
| 18 |
SPHERA FUNDS MANAGEMENT LTD. |
110,000 |
2,725,000 |
0.70% |
|
|
| 19 |
STATE STREET CORP |
108,711 |
2,690,000 |
0.69% |
|
|
| 20 |
NORTHERN TRUST CORP |
94,249 |
2,335,000 |
0.60% |
|
|
| 21 |
WASATCH ADVISORS LP |
91,647 |
2,270,000 |
0.58% |
|
|
| 22 |
MASON STREET ADVISORS, LLC |
89,640 |
2,220,000 |
0.57% |
|
|
| 23 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
53,300 |
1,320,000 |
0.34% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
51,241 |
1,269,000 |
0.32% |
|
|
| 25 |
COLUMBUS CIRCLE INVESTORS |
48,029 |
1,190,000 |
0.30% |
|
|
| 26 |
Bank of New York Mellon Corp |
38,592 |
956,000 |
0.24% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
37,769 |
936,000 |
0.24% |
|
|
| 28 |
MILLENNIUM MANAGEMENT LLC |
36,203 |
897,000 |
0.23% |
|
|
| 29 |
BlackRock Investment Management, LLC |
30,177 |
747,000 |
0.19% |
|
|
| 30 |
Informed Momentum Co LLC |
29,730 |
736,000 |
0.19% |
|
|
| 31 |
Nationwide Fund Advisors |
27,286 |
676,000 |
0.17% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
26,635 |
660,000 |
0.17% |
|
|
| 33 |
RUSSELL FRANK CO/ |
24,110 |
597,000 |
0.15% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,200 |
476,000 |
0.12% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
16,000 |
397,000 |
0.10% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
15,358 |
380,000 |
0.10% |
|
|
| 37 |
TFS CAPITAL LLC |
14,626 |
362,000 |
0.09% |
|
|
| 38 |
MACQUARIE GROUP LTD |
12,976 |
321,000 |
0.08% |
|
|
| 39 |
COMMONWEALTH BANK OF AUSTRALIA |
12,630 |
313,000 |
0.08% |
|
|
| 40 |
CREDIT SUISSE AG/ |
11,175 |
277,000 |
0.07% |
|
|
| 41 |
JANE STREET GROUP, LLC |
9,338 |
231,000 |
0.06% |
|
|
| 42 |
METROPOLITAN LIFE INSURANCE CO/NY |
8,558 |
212,000 |
0.05% |
|
|
| 43 |
MORGAN STANLEY |
8,532 |
212,000 |
0.05% |
|
|
| 44 |
KEYBANK NATIONAL ASSOCIATION/OH |
8,480 |
210,000 |
0.05% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,562 |
188,000 |
0.05% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,873 |
170,244 |
0.04% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
6,451 |
159,000 |
0.04% |
|
|
| 48 |
ROYAL BANK OF CANADA |
6,175 |
153,000 |
0.04% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
3,400 |
84,000 |
0.02% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
2,080 |
52,000 |
0.01% |
|
|
