| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,468,495 | 71,763,000 | 17.58% | ||
| 2 | TPG Group Holdings (SBS) Advisors, Inc. | 3,387,466 | 70,087,000 | 17.17% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,304,380 | 68,366,000 | 16.75% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,324,917 | 48,103,000 | 11.78% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 502,224 | 10,391,000 | 2.55% | ||
| 6 | GOLDMAN SACHS GROUP INC | 488,329 | 10,104,000 | 2.47% | ||
| 7 | SCHRODER INVESTMENT MANAGEMENT GROUP | 404,100 | 8,360,829 | 2.05% | ||
| 8 | PUTNAM INVESTMENTS LLC | 319,900 | 6,619,000 | 1.62% | ||
| 9 | BAKER BROS. ADVISORS LP | 299,356 | 6,194,000 | 1.52% | ||
| 10 | WALL STREET ASSOCIATES | 266,800 | 5,520,000 | 1.35% | ||
| 11 | VANGUARD GROUP INC | 264,653 | 5,476,000 | 1.34% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 1,121,951 | 5,441,000 | 1.33% | ||
| 13 | BlackRock Fund Advisors | 249,098 | 5,154,000 | 1.26% | ||
| 14 | JPMORGAN CHASE & CO | 245,733 | 5,084,000 | 1.25% | ||
| 15 | JENNISON ASSOCIATES LLC | 231,725 | 4,794,000 | 1.17% | ||
| 16 | ESSEX INVESTMENT MANAGEMENT CO LLC | 212,627 | 4,399,000 | 1.08% | ||
| 17 | CITY NATIONAL BANK | 196,506 | 4,066,000 | 1.00% | ||
| 18 | STIFEL FINANCIAL CORP | 195,567 | 4,047,000 | 0.99% | ||
| 19 | JHL Capital Group LLC | 195,000 | 4,035,000 | 0.99% | ||
| 20 | Iguana Healthcare Management, LLC | 190,000 | 3,931,000 | 0.96% | ||
| 21 | SPHERA FUNDS MANAGEMENT LTD. | 163,516 | 3,383,000 | 0.83% | ||
| 22 | DAFNA Capital Management LLC | 145,342 | 3,007,000 | 0.74% | SH | |
| 23 | HARVEY CAPITAL MANAGEMENT INC | 136,400 | 2,822,000 | 0.69% | ||
| 24 | NORTHERN TRUST CORP | 136,152 | 2,817,000 | 0.69% | ||
| 25 | C WorldWide Group Holding A/S | 130,000 | 2,691,000 | 0.66% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 120,617 | 2,496,000 | 0.61% | ||
| 27 | STATE STREET CORP | 120,342 | 2,487,000 | 0.61% | ||
| 28 | MASON STREET ADVISORS, LLC | 104,330 | 2,159,000 | 0.53% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 101,295 | 2,096,000 | 0.51% | ||
| 30 | ROYCE & ASSOCIATES LP | 100,000 | 2,069,000 | 0.51% | ||
| 31 | Rock Springs Capital Management LP | 99,300 | 2,055,000 | 0.50% | ||
| 32 | Informed Momentum Co LLC | 92,489 | 1,914,000 | 0.47% | ||
| 33 | WASATCH ADVISORS LP | 92,326 | 1,910,000 | 0.47% | ||
| 34 | Bank of New York Mellon Corp | 79,523 | 1,646,000 | 0.40% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 79,368 | 1,642,000 | 0.40% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 76,072 | 1,573,000 | 0.39% | ||
| 37 | HealthCor Management, L.P. | 75,000 | 1,552,000 | 0.38% | ||
| 38 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 69,791 | 1,444,000 | 0.35% | ||
| 39 | RUSSELL FRANK CO/ | 67,288 | 1,392,000 | 0.34% | ||
| 40 | ROYAL BANK OF CANADA | 62,656 | 1,296,000 | 0.32% | ||
| 41 | HAMILTON LANE ADVISORS LLC | 62,080 | 1,284,000 | 0.31% | ||
| 42 | PLATINUM INVESTMENT MANAGEMENT LTD | 59,000 | 1,220,000 | 0.30% | ||
| 43 | Benchmark Capital Advisors | 47,000 | 972,000 | 0.24% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 44,469 | 920,000 | 0.23% | ||
| 45 | AMERIPRISE FINANCIAL INC | 38,796 | 803,000 | 0.20% | ||
| 46 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 33,410 | 691,000 | 0.17% | ||
| 47 | MACQUARIE GROUP LTD | 32,582 | 674,000 | 0.17% | ||
| 48 | BlackRock Investment Management, LLC | 30,576 | 633,000 | 0.16% | ||
| 49 | Nationwide Fund Advisors | 30,524 | 632,000 | 0.15% | ||
| 50 | Alyeska Investment Group, L.P. | 24,927 | 516,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
