| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,764,019 | 66,774,000 | 14.10% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,420,240 | 60,675,000 | 12.81% | ||
| 3 | PFM Health Sciences, LP | 2,218,198 | 39,351,000 | 8.31% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 26,610,000 | 5.62% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,305,553 | 23,161,000 | 4.89% | ||
| 6 | TPG Group Holdings (SBS) Advisors, Inc. | 1,237,466 | 21,953,000 | 4.64% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,000,000 | 17,740,000 | 3.75% | Call | |
| 8 | Foresite Capital Management II, LLC | 906,317 | 16,078,000 | 3.40% | ||
| 9 | BlackRock Fund Advisors | 906,167 | 16,075,000 | 3.39% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 807,875 | 14,332,000 | 3.03% | ||
| 11 | VANGUARD GROUP INC | 701,290 | 12,441,000 | 2.63% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 572,341 | 10,153,000 | 2.14% | ||
| 13 | NORTHPOINTE CAPITAL LLC | 443,125 | 7,861,000 | 1.66% | ||
| 14 | SCHRODER INVESTMENT MANAGEMENT GROUP | 419,500 | 7,442,000 | 1.57% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 417,600 | 7,408,000 | 1.56% | Call | |
| 16 | ALPS ADVISORS INC | 40,215 | 7,134,000 | 1.51% | ||
| 17 | PUTNAM INVESTMENTS LLC | 319,900 | 5,675,000 | 1.20% | ||
| 18 | WEATHERBIE CAPITAL, LLC | 301,293 | 5,345,000 | 1.13% | ||
| 19 | BAKER BROS. ADVISORS LP | 299,356 | 5,311,000 | 1.12% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 283,973 | 5,038,000 | 1.06% | ||
| 21 | STATE STREET CORP | 281,779 | 4,996,000 | 1.05% | ||
| 22 | NORTHERN TRUST CORP | 255,499 | 4,532,000 | 0.96% | ||
| 23 | AMERIPRISE FINANCIAL INC | 247,409 | 4,389,000 | 0.93% | ||
| 24 | Invesco Ltd. | 217,977 | 3,867,000 | 0.82% | ||
| 25 | C WorldWide Group Holding A/S | 201,350 | 3,572,000 | 0.75% | ||
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 200,000 | 3,548,000 | 0.75% | ||
| 27 | WADDELL & REED FINANCIAL INC | 184,600 | 3,275,000 | 0.69% | ||
| 28 | BARCLAYS PLC | 182,286 | 3,100,000 | 0.65% | ||
| 29 | DAFNA Capital Management LLC | 165,669 | 2,939,000 | 0.62% | SH | |
| 30 | FRED ALGER MANAGEMENT, LLC | 150,894 | 2,677,000 | 0.57% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 147,951 | 2,624,000 | 0.55% | ||
| 32 | Bank of New York Mellon Corp | 128,834 | 2,286,000 | 0.48% | ||
| 33 | PLATINUM INVESTMENT MANAGEMENT LTD | 122,000 | 2,164,000 | 0.46% | ||
| 34 | HARVEY CAPITAL MANAGEMENT INC | 121,850 | 2,161,000 | 0.46% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 110,518 | 1,961,000 | 0.41% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,800 | 1,841,000 | 0.39% | Put | |
| 37 | Boulegeris Investments, Inc. | 93,320 | 1,655,000 | 0.35% | ||
| 38 | STIFEL FINANCIAL CORP | 90,283 | 1,602,000 | 0.34% | ||
| 39 | ROYAL BANK OF CANADA | 89,112 | 1,581,000 | 0.33% | ||
| 40 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 85,834 | 1,523,000 | 0.32% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 80,021 | 1,419,000 | 0.30% | ||
| 42 | RICE HALL JAMES & ASSOCIATES, LLC | 78,376 | 1,390,000 | 0.29% | ||
| 43 | COLUMBUS CIRCLE INVESTORS | 75,756 | 1,344,000 | 0.28% | ||
| 44 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 73,411 | 1,302,000 | 0.27% | ||
| 45 | BlackRock Investment Management, LLC | 73,265 | 1,300,000 | 0.27% | ||
| 46 | Granite Point Capital Management, L.P. | 70,000 | 1,242,000 | 0.26% | ||
| 47 | GOLDMAN SACHS GROUP INC | 69,500 | 1,233,000 | 0.26% | Call | |
| 48 | Clarus Ventures, LLC | 63,017 | 1,118,000 | 0.24% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,808 | 1,096,000 | 0.23% | ||
| 50 | Iguana Healthcare Management, LLC | 60,015 | 1,065,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
