| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,564,245 | 134,515,000 | 10.59% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,259,878 | 123,028,000 | 9.68% | ||
| 3 | PFM Health Sciences, LP | 1,966,417 | 74,213,000 | 5.84% | ||
| 4 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,697,884 | 64,078,000 | 5.04% | ||
| 5 | Foresite Capital Management II, LLC | 1,672,714 | 63,128,000 | 4.97% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,650,784 | 62,301,000 | 4.90% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,338,829 | 50,527,000 | 3.98% | ||
| 8 | TPG Group Holdings (SBS) Advisors, Inc. | 1,237,466 | 46,702,000 | 3.68% | ||
| 9 | VANGUARD GROUP INC | 1,136,658 | 42,897,000 | 3.38% | ||
| 10 | BlackRock Fund Advisors | 1,042,480 | 39,343,000 | 3.10% | ||
| 11 | ORBIMED ADVISORS LLC | 797,100 | 30,083,000 | 2.37% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 685,163 | 25,858,000 | 2.03% | ||
| 13 | STATE STREET CORP | 599,498 | 22,626,000 | 1.78% | ||
| 14 | AMERIPRISE FINANCIAL INC | 595,292 | 22,465,000 | 1.77% | ||
| 15 | CITADEL ADVISORS LLC | 559,054 | 21,100,000 | 1.66% | ||
| 16 | Avoro Capital Advisors LLC | 500,000 | 18,870,000 | 1.49% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 423,122 | 15,969,000 | 1.26% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 406,771 | 15,352,000 | 1.21% | ||
| 19 | WEATHERBIE CAPITAL, LLC | 383,118 | 14,459,000 | 1.14% | ||
| 20 | NORTHERN TRUST CORP | 336,128 | 12,686,000 | 1.00% | ||
| 21 | PUTNAM INVESTMENTS LLC | 325,389 | 12,280,000 | 0.97% | ||
| 22 | Ghost Tree Capital, LLC | 300,000 | 11,322,000 | 0.89% | Call | |
| 23 | BAKER BROS. ADVISORS LP | 299,356 | 11,298,000 | 0.89% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 292,511 | 11,039,000 | 0.87% | ||
| 25 | ACUTA CAPITAL PARTNERS, LLC | 280,000 | 10,567,000 | 0.83% | ||
| 26 | NORTHPOINTE CAPITAL LLC | 275,714 | 10,405,000 | 0.82% | ||
| 27 | GOLDMAN SACHS GROUP INC | 257,842 | 9,731,000 | 0.77% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 249,200 | 9,405,000 | 0.74% | ||
| 29 | BARCLAYS PLC | 245,165 | 9,253,000 | 0.73% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 221,458 | 8,358,000 | 0.66% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 210,534 | 7,945,000 | 0.63% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,600 | 7,759,000 | 0.61% | Put | |
| 33 | RICE HALL JAMES & ASSOCIATES, LLC | 198,058 | 7,475,000 | 0.59% | ||
| 34 | WADDELL & REED FINANCIAL INC | 192,100 | 7,250,000 | 0.57% | ||
| 35 | FRED ALGER MANAGEMENT, LLC | 182,414 | 6,884,000 | 0.54% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 172,585 | 6,513,000 | 0.51% | ||
| 37 | Iguana Healthcare Management, LLC | 165,000 | 6,227,000 | 0.49% | ||
| 38 | Bank of New York Mellon Corp | 159,497 | 6,019,000 | 0.47% | ||
| 39 | ESSEX INVESTMENT MANAGEMENT CO LLC | 154,105 | 5,816,000 | 0.46% | ||
| 40 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 150,651 | 5,686,000 | 0.45% | ||
| 41 | C WorldWide Group Holding A/S | 141,500 | 5,340,000 | 0.42% | ||
| 42 | Granite Point Capital Management, L.P. | 134,500 | 5,076,000 | 0.40% | ||
| 43 | Alyeska Investment Group, L.P. | 133,951 | 5,055,000 | 0.40% | ||
| 44 | FMR LLC | 132,300 | 4,993,000 | 0.39% | ||
| 45 | WALL STREET ASSOCIATES | 128,400 | 4,846,000 | 0.38% | ||
| 46 | Ghost Tree Capital, LLC | 125,000 | 4,718,000 | 0.37% | ||
| 47 | Informed Momentum Co LLC | 124,932 | 4,715,000 | 0.37% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 122,000 | 4,604,000 | 0.36% | Call | |
| 49 | D. E. Shaw & Co., Inc. | 121,896 | 4,600,000 | 0.36% | ||
| 50 | RAYMOND JAMES & ASSOCIATES | 116,929 | 4,413,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
