| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,366,106 | 105,494,000 | 15.03% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,981,201 | 93,431,000 | 13.31% | ||
| 3 | TPG Group Holdings (SBS) Advisors, Inc. | 1,837,466 | 57,586,000 | 8.20% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 966,812 | 30,300,000 | 4.32% | ||
| 5 | STATE STREET CORP | 844,766 | 26,476,000 | 3.77% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 606,118 | 18,996,000 | 2.71% | ||
| 7 | BlackRock Fund Advisors | 598,292 | 18,750,000 | 2.67% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 559,341 | 17,530,000 | 2.50% | ||
| 9 | VANGUARD GROUP INC | 541,958 | 16,985,000 | 2.42% | ||
| 10 | SCHRODER INVESTMENT MANAGEMENT GROUP | 475,700 | 14,694,000 | 2.09% | ||
| 11 | FRED ALGER MANAGEMENT, LLC | 432,689 | 13,560,000 | 1.93% | ||
| 12 | Novo Holdings A/S | 419,652 | 13,152,000 | 1.87% | ||
| 13 | CHARTWELL INVESTMENT PARTNERS, LLC | 354,045 | 11,096,000 | 1.58% | ||
| 14 | HealthCor Management, L.P. | 350,000 | 10,969,000 | 1.56% | ||
| 15 | BAMCO INC /NY/ | 330,451 | 10,356,000 | 1.48% | ||
| 16 | NORTHPOINTE CAPITAL LLC | 327,912 | 10,277,000 | 1.46% | ||
| 17 | PUTNAM INVESTMENTS LLC | 319,900 | 10,026,000 | 1.43% | ||
| 18 | GOLDMAN SACHS GROUP INC | 317,620 | 9,955,000 | 1.42% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 313,211 | 9,816,000 | 1.40% | ||
| 20 | BAKER BROS. ADVISORS LP | 299,356 | 9,382,000 | 1.34% | ||
| 21 | CITY NATIONAL BANK | 285,009 | 8,932,000 | 1.27% | ||
| 22 | ESSEX INVESTMENT MANAGEMENT CO LLC | 283,725 | 8,892,000 | 1.27% | ||
| 23 | WALL STREET ASSOCIATES | 253,700 | 7,951,000 | 1.13% | ||
| 24 | Candriam S.C.A. | 243,000 | 7,617,000 | 1.08% | ||
| 25 | PFM Health Sciences, LP | 235,445 | 7,379,000 | 1.05% | ||
| 26 | Foresite Capital Management II, LLC | 210,067 | 6,583,000 | 0.94% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 200,000 | 6,268,000 | 0.89% | Call | |
| 28 | VOYA INVESTMENT MANAGEMENT LLC | 192,847 | 6,044,000 | 0.86% | ||
| 29 | FMR LLC | 186,300 | 5,839,000 | 0.83% | ||
| 30 | STIFEL FINANCIAL CORP | 171,169 | 5,364,000 | 0.76% | ||
| 31 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 164,258 | 5,148,000 | 0.73% | ||
| 32 | DAFNA Capital Management LLC | 160,242 | 5,022,000 | 0.72% | SH | |
| 33 | Asset Management One Co., Ltd. | 149,714 | 4,681,000 | 0.67% | ||
| 34 | NORTHERN TRUST CORP | 147,953 | 4,637,000 | 0.66% | ||
| 35 | HARVEY CAPITAL MANAGEMENT INC | 147,400 | 4,619,000 | 0.66% | ||
| 36 | Rock Springs Capital Management LP | 146,000 | 4,576,000 | 0.65% | ||
| 37 | Iguana Healthcare Management, LLC | 120,000 | 3,761,000 | 0.54% | ||
| 38 | AMERICAN CENTURY COMPANIES INC | 116,829 | 3,661,000 | 0.52% | ||
| 39 | Informed Momentum Co LLC | 115,038 | 3,605,000 | 0.51% | ||
| 40 | EverPoint Asset Management, LLC | 110,000 | 3,447,000 | 0.49% | ||
| 41 | AMERIPRISE FINANCIAL INC | 107,302 | 3,363,000 | 0.48% | ||
| 42 | DRIEHAUS CAPITAL MANAGEMENT LLC | 103,722 | 3,251,000 | 0.46% | ||
| 43 | ROYAL BANK OF CANADA | 103,095 | 3,231,000 | 0.46% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 101,400 | 3,178,000 | 0.45% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 94,864 | 2,973,000 | 0.42% | ||
| 46 | C WorldWide Group Holding A/S | 90,903 | 2,849,000 | 0.41% | ||
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 90,000 | 2,821,000 | 0.40% | ||
| 48 | Bank of New York Mellon Corp | 89,740 | 2,813,000 | 0.40% | ||
| 49 | ROYCE & ASSOCIATES LP | 86,000 | 2,695,000 | 0.38% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 83,688 | 2,622,000 | 0.37% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
