| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TPG Group Holdings (SBS) Advisors, Inc. | 4,387,466 | 92,970,000 | 31.14% | ||
| 2 | Clarus Ventures, LLC | 3,468,495 | 73,497,000 | 24.62% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,916,748 | 40,616,000 | 13.60% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 565,180 | 11,976,000 | 4.01% | ||
| 5 | SCHRODER INVESTMENT MANAGEMENT GROUP | 401,700 | 8,512,023 | 2.85% | ||
| 6 | PUTNAM INVESTMENTS LLC | 321,000 | 6,802,000 | 2.28% | ||
| 7 | BAKER BROS. ADVISORS LP | 299,356 | 6,343,000 | 2.12% | ||
| 8 | WALL STREET ASSOCIATES | 299,100 | 6,338,000 | 2.12% | ||
| 9 | JENNISON ASSOCIATES LLC | 257,712 | 5,461,000 | 1.83% | ||
| 10 | BlackRock Fund Advisors | 221,123 | 4,686,000 | 1.57% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 211,518 | 4,482,000 | 1.50% | ||
| 12 | Iguana Healthcare Management, LLC | 210,000 | 4,450,000 | 1.49% | ||
| 13 | VANGUARD GROUP INC | 163,483 | 3,465,000 | 1.16% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 137,591 | 2,916,000 | 0.98% | ||
| 15 | ESSEX INVESTMENT MANAGEMENT CO LLC | 115,341 | 2,444,000 | 0.82% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 112,500 | 2,384,000 | 0.80% | ||
| 17 | STATE STREET CORP | 97,680 | 2,070,000 | 0.69% | ||
| 18 | WASATCH ADVISORS LP | 94,188 | 1,996,000 | 0.67% | ||
| 19 | NORTHERN TRUST CORP | 93,622 | 1,984,000 | 0.66% | ||
| 20 | MASON STREET ADVISORS, LLC | 89,640 | 1,899,000 | 0.64% | ||
| 21 | CITY NATIONAL BANK | 84,845 | 1,798,000 | 0.60% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 52,634 | 1,115,000 | 0.37% | ||
| 23 | Absolute Return Capital, LLC | 49,595 | 1,051,000 | 0.35% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 49,469 | 1,048,000 | 0.35% | ||
| 25 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 45,800 | 971,000 | 0.33% | ||
| 26 | ROYAL BANK OF CANADA | 42,727 | 905,000 | 0.30% | ||
| 27 | Bank of New York Mellon Corp | 32,911 | 697,000 | 0.23% | ||
| 28 | BLACKROCK ADVISORS LLC | 32,736 | 694,000 | 0.23% | ||
| 29 | Index Management Solutions, LLC | 30,892 | 655,000 | 0.22% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,969 | 550,000 | 0.18% | ||
| 31 | Nationwide Fund Advisors | 25,193 | 534,000 | 0.18% | ||
| 32 | BlackRock Investment Management, LLC | 22,533 | 477,000 | 0.16% | ||
| 33 | TFS CAPITAL LLC | 19,855 | 421,000 | 0.14% | ||
| 34 | CREDIT SUISSE AG/ | 17,434 | 370,000 | 0.12% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,000 | 297,000 | 0.10% | ||
| 36 | TEACHERS ADVISORS, LLC | 12,380 | 262,000 | 0.09% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,200 | 238,000 | 0.08% | ||
| 38 | COMMONWEALTH BANK OF AUSTRALIA | 11,000 | 233,000 | 0.08% | ||
| 39 | PDT Partners, LLC | 10,734 | 227,000 | 0.08% | ||
| 40 | DEUTSCHE BANK AG\ | 6,913 | 146,000 | 0.05% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,539 | 139,000 | 0.05% | ||
| 42 | AMERICAN INTERNATIONAL GROUP, INC. | 5,255 | 111,353 | 0.04% | ||
| 43 | MORGAN STANLEY | 4,964 | 105,000 | 0.04% | ||
| 44 | CITIGROUP INC | 3,774 | 80,000 | 0.03% | ||
| 45 | STRS OHIO | 1,500 | 32,000 | 0.01% | ||
| 46 | BlackRock Japan Co. Ltd | 1,049 | 22,000 | 0.01% | ||
| 47 | SHAPIRO ROBERT N | 888 | 19,000 | 0.01% | ||
| 48 | Global X Management CO LLC | 909 | 19,000 | 0.01% | ||
| 49 | UBS AG | 768 | 17,000 | 0.01% | ||
| 50 | WELLS FARGO & COMPANY/MN | 500 | 11,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
