| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,338,067 | 97,438,000 | 15.22% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,324,170 | 97,032,000 | 15.16% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,369,583 | 69,168,000 | 10.81% | ||
| 4 | TPG Group Holdings (SBS) Advisors, Inc. | 2,087,466 | 60,933,000 | 9.52% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,858,917 | 54,262,000 | 8.48% | ||
| 6 | STIFEL FINANCIAL CORP | 492,162 | 20,911,000 | 3.27% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 670,713 | 19,578,000 | 3.06% | ||
| 8 | BlackRock Fund Advisors | 573,672 | 16,745,000 | 2.62% | ||
| 9 | Novo Holdings A/S | 419,652 | 12,250,000 | 1.91% | ||
| 10 | SCHRODER INVESTMENT MANAGEMENT GROUP | 380,200 | 11,098,000 | 1.73% | ||
| 11 | VANGUARD GROUP INC | 327,233 | 9,551,000 | 1.49% | ||
| 12 | PUTNAM INVESTMENTS LLC | 319,900 | 9,338,000 | 1.46% | ||
| 13 | Candriam S.C.A. | 310,000 | 9,049,000 | 1.41% | ||
| 14 | BAKER BROS. ADVISORS LP | 299,356 | 8,738,000 | 1.37% | ||
| 15 | GOLDMAN SACHS GROUP INC | 266,387 | 7,776,000 | 1.21% | ||
| 16 | WALL STREET ASSOCIATES | 262,400 | 7,659,000 | 1.20% | ||
| 17 | Foresite Capital Management II, LLC | 220,067 | 6,424,000 | 1.00% | ||
| 18 | CITY NATIONAL BANK | 215,569 | 6,293,000 | 0.98% | ||
| 19 | ESSEX INVESTMENT MANAGEMENT CO LLC | 210,396 | 6,141,000 | 0.96% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 186,068 | 5,431,000 | 0.85% | ||
| 21 | CHARTWELL INVESTMENT PARTNERS, LLC | 184,905 | 5,397,000 | 0.84% | ||
| 22 | EverPoint Asset Management, LLC | 152,500 | 4,451,000 | 0.70% | ||
| 23 | Iguana Healthcare Management, LLC | 150,000 | 4,379,000 | 0.68% | ||
| 24 | ROYCE & ASSOCIATES LP | 143,000 | 4,174,000 | 0.65% | ||
| 25 | Rock Springs Capital Management LP | 140,000 | 4,087,000 | 0.64% | ||
| 26 | NORTHERN TRUST CORP | 136,998 | 3,999,000 | 0.62% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 136,392 | 3,981,000 | 0.62% | ||
| 28 | HARVEY CAPITAL MANAGEMENT INC | 135,400 | 3,952,000 | 0.62% | ||
| 29 | DAFNA Capital Management LLC | 132,442 | 3,866,000 | 0.60% | ||
| 30 | Informed Momentum Co LLC | 129,816 | 3,789,000 | 0.59% | ||
| 31 | STATE STREET CORP | 129,232 | 3,772,000 | 0.59% | ||
| 32 | Asset Management One Co., Ltd. | 117,427 | 3,526,000 | 0.55% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 111,548 | 3,256,000 | 0.51% | ||
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 106,559 | 3,110,000 | 0.49% | ||
| 35 | MASON STREET ADVISORS, LLC | 104,330 | 3,045,000 | 0.48% | ||
| 36 | Bank of New York Mellon Corp | 91,331 | 2,666,000 | 0.42% | ||
| 37 | C WorldWide Group Holding A/S | 90,903 | 2,653,000 | 0.41% | ||
| 38 | SPHERA FUNDS MANAGEMENT LTD. | 88,516 | 2,584,000 | 0.40% | ||
| 39 | COLUMBUS CIRCLE INVESTORS | 85,932 | 2,508,000 | 0.39% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 81,810 | 2,388,000 | 0.37% | ||
| 41 | WASATCH ADVISORS LP | 76,787 | 2,241,000 | 0.35% | ||
| 42 | ROYAL BANK OF CANADA | 76,308 | 2,227,000 | 0.35% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 73,411 | 2,143,000 | 0.33% | ||
| 44 | RUSSELL FRANK CO/ | 71,538 | 2,079,000 | 0.32% | ||
| 45 | PLATINUM INVESTMENT MANAGEMENT LTD | 59,000 | 1,722,000 | 0.27% | ||
| 46 | KENNEDY CAPITAL MANAGEMENT LLC | 53,181 | 1,552,000 | 0.24% | ||
| 47 | Benchmark Capital Advisors | 48,900 | 1,427,000 | 0.22% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 41,761 | 1,219,000 | 0.19% | ||
| 49 | AMERIPRISE FINANCIAL INC | 40,968 | 1,196,000 | 0.19% | ||
| 50 | BAMCO INC /NY/ | 39,800 | 1,162,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
