| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,364,832 | 59,389,000 | 14.00% | ||
| 2 | JENNISON ASSOCIATES LLC | 3,094,909 | 54,625,000 | 12.87% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,211,644 | 39,036,000 | 9.20% | ||
| 4 | PFM Health Sciences, LP | 1,851,564 | 32,680,000 | 7.70% | ||
| 5 | TPG Group Holdings (SBS) Advisors, Inc. | 1,237,466 | 21,841,000 | 5.15% | ||
| 6 | SCHRODER INVESTMENT MANAGEMENT GROUP | 1,185,300 | 20,363,000 | 4.80% | ||
| 7 | NORTHPOINTE CAPITAL LLC | 1,034,400 | 18,257,000 | 4.30% | ||
| 8 | BlackRock Fund Advisors | 869,649 | 15,349,000 | 3.62% | ||
| 9 | Foresite Capital Management II, LLC | 805,217 | 14,212,000 | 3.35% | ||
| 10 | VANGUARD GROUP INC | 579,159 | 10,222,000 | 2.41% | ||
| 11 | VOYA INVESTMENT MANAGEMENT LLC | 390,940 | 6,900,000 | 1.63% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 379,981 | 6,707,000 | 1.58% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 364,379 | 6,431,000 | 1.52% | ||
| 14 | AMERIPRISE FINANCIAL INC | 344,929 | 6,088,000 | 1.43% | ||
| 15 | C WorldWide Group Holding A/S | 326,503 | 5,763,000 | 1.36% | ||
| 16 | PUTNAM INVESTMENTS LLC | 319,900 | 5,646,000 | 1.33% | ||
| 17 | BAKER BROS. ADVISORS LP | 299,356 | 5,284,000 | 1.25% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 284,251 | 5,017,000 | 1.18% | ||
| 19 | GOLDMAN SACHS GROUP INC | 284,149 | 5,016,000 | 1.18% | ||
| 20 | WALL STREET ASSOCIATES | 244,000 | 4,307,000 | 1.02% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,300 | 3,994,000 | 0.94% | Call | |
| 22 | HARVEY CAPITAL MANAGEMENT INC | 223,200 | 3,856,000 | 0.91% | ||
| 23 | STATE STREET CORP | 212,852 | 3,756,000 | 0.89% | ||
| 24 | FRED ALGER MANAGEMENT, LLC | 195,035 | 3,442,000 | 0.81% | ||
| 25 | WEATHERBIE CAPITAL, LLC | 172,115 | 3,038,000 | 0.72% | ||
| 26 | A.R.T. Advisors, LLC | 169,438 | 2,990,000 | 0.70% | ||
| 27 | DAFNA Capital Management LLC | 156,842 | 2,768,000 | 0.65% | SH | |
| 28 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 150,000 | 2,648,000 | 0.62% | ||
| 29 | NORTHERN TRUST CORP | 140,090 | 2,472,000 | 0.58% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 139,900 | 2,469,000 | 0.58% | Put | |
| 31 | STIFEL FINANCIAL CORP | 127,956 | 2,258,000 | 0.53% | ||
| 32 | PLATINUM INVESTMENT MANAGEMENT LTD | 122,000 | 2,153,000 | 0.51% | ||
| 33 | Novo Holdings A/S | 100,000 | 1,765,000 | 0.42% | ||
| 34 | Bank of New York Mellon Corp | 99,767 | 1,761,000 | 0.42% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 94,196 | 1,662,000 | 0.39% | ||
| 36 | RAYMOND JAMES & ASSOCIATES | 92,130 | 1,626,000 | 0.38% | ||
| 37 | ROYAL BANK OF CANADA | 91,796 | 1,620,000 | 0.38% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 88,941 | 1,570,000 | 0.37% | ||
| 39 | Boulegeris Investments, Inc. | 88,660 | 1,565,000 | 0.37% | ||
| 40 | ROYCE & ASSOCIATES LP | 86,000 | 1,518,000 | 0.36% | ||
| 41 | CITY NATIONAL BANK | 82,259 | 1,452,000 | 0.34% | ||
| 42 | MORGAN STANLEY | 76,203 | 1,345,000 | 0.32% | ||
| 43 | BlackRock Investment Management, LLC | 73,851 | 1,303,000 | 0.31% | ||
| 44 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 73,411 | 1,296,000 | 0.31% | ||
| 45 | SIMPLEX TRADING, LLC | 70,424 | 1,242,000 | 0.29% | ||
| 46 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 70,107 | 1,238,000 | 0.29% | ||
| 47 | KENNEDY CAPITAL MANAGEMENT LLC | 62,122 | 1,096,000 | 0.26% | ||
| 48 | Forward Management, LLC | 102,405 | 1,038,000 | 0.24% | ||
| 49 | MANAGED ACCOUNT ADVISORS LLC | 56,365 | 994,000 | 0.23% | ||
| 50 | Benchmark Capital Advisors | 55,400 | 978,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
