| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 9,259,260 | 28,137,000 | 33.46% | ||
| 2 | ORBIMED ADVISORS LLC | 5,050,000 | 16,009,000 | 19.04% | ||
| 3 | VANGUARD GROUP INC | 1,548,910 | 4,910,000 | 5.84% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,409,875 | 4,469,000 | 5.31% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 1,375,634 | 4,360,763 | 5.19% | ||
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,106,475 | 3,507,000 | 4.17% | ||
| 7 | Broadfin Capital, LLC | 1,055,000 | 3,344,000 | 3.98% | ||
| 8 | Cormorant Asset Management, LP | 1,000,000 | 3,170,000 | 3.77% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 525,368 | 1,665,000 | 1.98% | ||
| 10 | Artal Group S.A. | 410,130 | 1,300,000 | 1.55% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 256,735 | 813,000 | 0.97% | ||
| 12 | Bruce & Co., Inc. | 233,515 | 740,000 | 0.88% | ||
| 13 | ADVENT CAPITAL MANAGEMENT /DE/ | 220,000 | 697,000 | 0.83% | ||
| 14 | First Eagle Investment Management, LLC | 200,000 | 634,000 | 0.75% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 200,000 | 634,000 | 0.75% | ||
| 16 | CREDIT SUISSE AG/ | 189,551 | 601,000 | 0.71% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 187,333 | 594,000 | 0.71% | ||
| 18 | SABBY MANAGEMENT, LLC | 185,830 | 589,000 | 0.70% | ||
| 19 | BlackRock Fund Advisors | 169,999 | 539,000 | 0.64% | ||
| 20 | GOLDMAN SACHS GROUP INC | 169,926 | 539,000 | 0.64% | ||
| 21 | DEERE & CO | 168,405 | 534,000 | 0.64% | ||
| 22 | FMR LLC | 159,514 | 506,000 | 0.60% | ||
| 23 | D. E. Shaw & Co., Inc. | 147,283 | 467,000 | 0.56% | ||
| 24 | UBS AG | 138,703 | 439,000 | 0.52% | ||
| 25 | BlackRock Group LTD | 130,579 | 414,000 | 0.49% | ||
| 26 | HAP Trading, LLC | 124,365 | 394,000 | 0.47% | ||
| 27 | MORGAN STANLEY | 123,386 | 391,000 | 0.46% | ||
| 28 | NORTHERN TRUST CORP | 114,250 | 362,000 | 0.43% | ||
| 29 | JANE STREET GROUP, LLC | 113,737 | 361,000 | 0.43% | ||
| 30 | BLAIR WILLIAM & CO/IL | 113,125 | 358,000 | 0.43% | ||
| 31 | SOROS FUND MANAGEMENT LLC | 102,200 | 324,000 | 0.39% | ||
| 32 | WELLS FARGO & COMPANY/MN | 73,829 | 234,000 | 0.28% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 74,453 | 204,000 | 0.24% | ||
| 34 | LMR Partners LLP | 52,099 | 165,000 | 0.20% | ||
| 35 | Weiss Multi-Strategy Advisers LLC | 50,000 | 159,000 | 0.19% | ||
| 36 | DELTEC ASSET MANAGEMENT LLC | 50,000 | 159,000 | 0.19% | ||
| 37 | STATE STREET CORP | 45,814 | 145,000 | 0.17% | ||
| 38 | Bank of New York Mellon Corp | 40,345 | 128,000 | 0.15% | ||
| 39 | SG Americas Securities, LLC | 35,086 | 111,000 | 0.13% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 32,250 | 102,000 | 0.12% | ||
| 41 | JPMORGAN CHASE & CO | 30,304 | 96,000 | 0.11% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 28,392 | 90,000 | 0.11% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,500 | 90,000 | 0.11% | Call | |
| 44 | Rotella Capital Management, Inc. | 26,032 | 83,000 | 0.10% | ||
| 45 | GSA CAPITAL PARTNERS LLP | 24,576 | 78,000 | 0.09% | ||
| 46 | TUDOR INVESTMENT CORP ET AL | 17,411 | 55,000 | 0.07% | ||
| 47 | CITADEL ADVISORS LLC | 16,576 | 53,000 | 0.06% | ||
| 48 | BLACKROCK ADVISORS LLC | 13,328 | 42,000 | 0.05% | ||
| 49 | TFS CAPITAL LLC | 13,046 | 41,000 | 0.05% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,000 | 38,000 | 0.05% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
