| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 4,141,644 | 29,737,000 | 10.67% | ||
| 2 | Avoro Capital Advisors LLC | 3,715,938 | 26,680,000 | 9.57% | ||
| 3 | QVT Financial LP | 3,218,707 | 23,110,000 | 8.29% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 2,991,664 | 21,480,000 | 7.71% | ||
| 5 | VANGUARD GROUP INC | 2,920,151 | 20,966,000 | 7.52% | ||
| 6 | FMR LLC | 2,153,616 | 15,463,000 | 5.55% | ||
| 7 | STATE STREET CORP | 2,131,759 | 15,308,000 | 5.49% | ||
| 8 | BlackRock Fund Advisors | 2,019,200 | 14,498,000 | 5.20% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,869,034 | 13,420,000 | 4.81% | ||
| 10 | Cormorant Asset Management, LP | 1,578,106 | 11,331,000 | 4.06% | ||
| 11 | Artal Group S.A. | 1,000,000 | 7,180,000 | 2.58% | ||
| 12 | Zurcher Kantonalbank (Zurich Cantonalbank) | 990,738 | 7,113,000 | 2.55% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 900,000 | 6,462,000 | 2.32% | ||
| 14 | NORTHERN TRUST CORP | 820,045 | 5,888,000 | 2.11% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 528,942 | 3,797,000 | 1.36% | ||
| 16 | Candriam S.C.A. | 517,700 | 3,717,000 | 1.33% | ||
| 17 | Artal Group S.A. | 500,000 | 3,590,000 | 1.29% | Call | |
| 18 | WELLS FARGO & COMPANY/MN | 421,516 | 3,026,000 | 1.09% | ||
| 19 | MORGAN STANLEY | 409,841 | 2,943,000 | 1.06% | ||
| 20 | Bank of New York Mellon Corp | 326,532 | 2,344,000 | 0.84% | ||
| 21 | BlackRock Investment Management, LLC | 298,268 | 2,142,000 | 0.77% | ||
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 291,809 | 2,096,000 | 0.75% | ||
| 23 | Allianz Asset Management GmbH | 286,972 | 2,060,000 | 0.74% | ||
| 24 | D. E. Shaw & Co., Inc. | 270,660 | 1,943,000 | 0.70% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,600 | 1,742,000 | 0.62% | Put | |
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 226,518 | 1,626,000 | 0.58% | ||
| 27 | HAP Trading, LLC | 225,573 | 1,620,000 | 0.58% | ||
| 28 | DEUTSCHE BANK AG\ | 198,795 | 1,426,000 | 0.51% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 181,977 | 1,307,000 | 0.47% | ||
| 30 | Vident Investment Advisory, LLC | 167,654 | 1,204,000 | 0.43% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 154,358 | 1,108,000 | 0.40% | ||
| 32 | Bruce & Co., Inc. | 155,677 | 1,089,000 | 0.39% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 148,500 | 1,066,000 | 0.38% | ||
| 34 | BAILARD, INC. | 148,000 | 1,063,000 | 0.38% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 143,500 | 1,030,000 | 0.37% | Call | |
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,700 | 982,000 | 0.35% | Call | |
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 132,753 | 953,000 | 0.34% | ||
| 38 | TEACHERS ADVISORS, LLC | 117,247 | 842,000 | 0.30% | ||
| 39 | Avoro Capital Advisors LLC | 1,000,000 | 800,000 | 0.29% | Call | |
| 40 | ACUTA CAPITAL PARTNERS, LLC | 104,178 | 748,000 | 0.27% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 91,000 | 653,000 | 0.23% | ||
| 42 | CITADEL ADVISORS LLC | 88,898 | 638,000 | 0.23% | ||
| 43 | COWEN INC. | 79,900 | 574,000 | 0.21% | Put | |
| 44 | RHUMBLINE ADVISERS | 78,632 | 565,000 | 0.20% | ||
| 45 | GROUP ONE TRADING LLC | 72,126 | 518,000 | 0.19% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 69,600 | 500,000 | 0.18% | ||
| 47 | Creative Planning | 66,171 | 475,000 | 0.17% | ||
| 48 | VIRTUS ETF ADVISERS LLC | 63,191 | 454,000 | 0.16% | ||
| 49 | Shinko Asset Management Co., Ltd. | 62,549 | 449,000 | 0.16% | ||
| 50 | Fisher Asset Management, LLC | 62,549 | 449,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
