| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 3,877,072 | 16,129,000 | 11.10% | ||
| 2 | VANGUARD GROUP INC | 2,800,393 | 11,649,000 | 8.02% | ||
| 3 | FMR LLC | 2,587,878 | 10,766,000 | 7.41% | ||
| 4 | RTW INVESTMENTS, LP | 2,414,524 | 10,044,000 | 6.91% | ||
| 5 | Avoro Capital Advisors LLC | 2,400,868 | 9,988,000 | 6.88% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 2,004,288 | 8,338,000 | 5.74% | ||
| 7 | BlackRock Fund Advisors | 1,972,191 | 8,204,000 | 5.65% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,778,629 | 7,399,000 | 5.09% | ||
| 9 | Cormorant Asset Management, LP | 1,559,000 | 6,485,000 | 4.46% | ||
| 10 | Point72 Asset Management, L.P. | 1,536,948 | 6,394,000 | 4.40% | ||
| 11 | STATE STREET CORP | 1,167,816 | 4,859,000 | 3.35% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 1,140,315 | 4,744,000 | 3.27% | ||
| 13 | Zurcher Kantonalbank (Zurich Cantonalbank) | 955,918 | 3,977,000 | 2.74% | ||
| 14 | NORTHERN TRUST CORP | 846,849 | 3,523,000 | 2.43% | ||
| 15 | Artal Group S.A. | 750,000 | 3,120,000 | 2.15% | ||
| 16 | Artal Group S.A. | 500,000 | 2,080,000 | 1.43% | Call | |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 494,971 | 2,059,000 | 1.42% | ||
| 18 | Candriam S.C.A. | 457,700 | 1,894,000 | 1.30% | ||
| 19 | DEUTSCHE BANK AG\ | 422,883 | 1,757,000 | 1.21% | ||
| 20 | WELLS FARGO & COMPANY/MN | 364,119 | 1,515,000 | 1.04% | ||
| 21 | Bank of New York Mellon Corp | 332,730 | 1,385,000 | 0.95% | ||
| 22 | BlackRock Investment Management, LLC | 278,545 | 1,159,000 | 0.80% | ||
| 23 | A.R.T. Advisors, LLC | 251,352 | 1,045,000 | 0.72% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 245,142 | 1,020,000 | 0.70% | ||
| 25 | Bruce & Co., Inc. | 233,515 | 971,000 | 0.67% | ||
| 26 | BAILARD, INC. | 213,000 | 886,000 | 0.61% | ||
| 27 | Spark Investment Management LLC | 186,300 | 775,000 | 0.53% | ||
| 28 | MORGAN STANLEY | 165,045 | 687,000 | 0.47% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 161,815 | 673,000 | 0.46% | ||
| 30 | Weiss Multi-Strategy Advisers LLC | 157,000 | 653,000 | 0.45% | ||
| 31 | Trellus Management Company, LLC | 150,000 | 624,000 | 0.43% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 146,353 | 609,000 | 0.42% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 131,100 | 545,000 | 0.38% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 118,383 | 492,000 | 0.34% | ||
| 35 | TEACHERS ADVISORS, LLC | 110,505 | 460,000 | 0.32% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,054 | 458,000 | 0.32% | ||
| 37 | Fisher Asset Management, LLC | 91,632 | 393,000 | 0.27% | ||
| 38 | Shinko Asset Management Co., Ltd. | 91,632 | 381,000 | 0.26% | ||
| 39 | D. E. Shaw & Co., Inc. | 86,414 | 359,000 | 0.25% | ||
| 40 | RHUMBLINE ADVISERS | 81,855 | 341,000 | 0.23% | ||
| 41 | METROPOLITAN LIFE INSURANCE CO/NY | 77,931 | 324,000 | 0.22% | ||
| 42 | Vident Investment Advisory, LLC | 1,336,100 | 322,000 | 0.22% | ||
| 43 | Squarepoint Ops LLC | 76,700 | 319,000 | 0.22% | ||
| 44 | CITIGROUP INC | 73,278 | 306,000 | 0.21% | ||
| 45 | CITADEL ADVISORS LLC | 70,019 | 292,000 | 0.20% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 69,600 | 290,000 | 0.20% | ||
| 47 | VIRTUS ETF ADVISERS LLC | 64,543 | 268,000 | 0.18% | ||
| 48 | Creative Planning | 62,409 | 260,000 | 0.18% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 59,400 | 247,000 | 0.17% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,200 | 246,000 | 0.17% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
