| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | STATE STREET CORP | 3,647,145 | 31,476,000 | 9.52% | ||
| 2 | QVT Financial LP | 3,233,081 | 27,901,000 | 8.44% | ||
| 3 | FMR LLC | 2,789,278 | 24,071,000 | 7.28% | ||
| 4 | VANGUARD GROUP INC | 2,332,425 | 20,129,000 | 6.09% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 2,287,013 | 19,737,000 | 5.97% | ||
| 6 | Avoro Capital Advisors LLC | 2,199,137 | 18,979,000 | 5.74% | ||
| 7 | RTW INVESTMENTS, LP | 2,052,915 | 17,717,000 | 5.36% | ||
| 8 | BlackRock Fund Advisors | 1,981,298 | 17,099,000 | 5.17% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,952,901 | 16,854,000 | 5.10% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 1,600,000 | 13,808,000 | 4.17% | ||
| 11 | Cormorant Asset Management, LP | 1,559,000 | 13,454,000 | 4.07% | ||
| 12 | GOLDMAN SACHS GROUP INC | 888,592 | 7,669,000 | 2.32% | ||
| 13 | NORTHERN TRUST CORP | 693,682 | 5,986,000 | 1.81% | ||
| 14 | TFS CAPITAL LLC | 605,649 | 5,227,000 | 1.58% | ||
| 15 | AQR CAPITAL MANAGEMENT LLC | 589,735 | 5,090,000 | 1.54% | ||
| 16 | Informed Momentum Co LLC | 567,720 | 4,899,000 | 1.48% | ||
| 17 | Artal Group S.A. | 530,090 | 4,575,000 | 1.38% | ||
| 18 | Candriam S.C.A. | 510,000 | 4,401,000 | 1.33% | ||
| 19 | Bank of New York Mellon Corp | 488,429 | 4,215,000 | 1.27% | ||
| 20 | ACUTA CAPITAL PARTNERS, LLC | 443,868 | 3,831,000 | 1.16% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 442,026 | 3,814,000 | 1.15% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 410,525 | 3,543,000 | 1.07% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 352,500 | 3,042,000 | 0.92% | Put | |
| 24 | CITADEL ADVISORS LLC | 344,246 | 2,971,000 | 0.90% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 343,200 | 2,962,000 | 0.90% | Call | |
| 26 | HIGHLAND CAPITAL MANAGEMENT LP | 339,572 | 2,931,000 | 0.89% | ||
| 27 | DEUTSCHE BANK AG\ | 309,254 | 2,667,000 | 0.81% | ||
| 28 | BlackRock Investment Management, LLC | 275,311 | 2,376,000 | 0.72% | ||
| 29 | Bruce & Co., Inc. | 233,515 | 2,015,000 | 0.61% | ||
| 30 | RUSSELL FRANK CO/ | 225,098 | 1,943,000 | 0.59% | ||
| 31 | PEAK6 Group LLC | 218,600 | 1,887,000 | 0.57% | Call | |
| 32 | PEAK6 Group LLC | 206,800 | 1,785,000 | 0.54% | Put | |
| 33 | AMERIPRISE FINANCIAL INC | 193,918 | 1,674,000 | 0.51% | ||
| 34 | BAILARD, INC. | 189,000 | 1,631,000 | 0.49% | ||
| 35 | SMITH ASSET MANAGEMENT GROUP LP | 171,792 | 1,483,000 | 0.45% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 167,015 | 1,441,000 | 0.44% | ||
| 37 | Trexquant Investment LP | 162,200 | 1,399,000 | 0.42% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 155,253 | 1,340,000 | 0.41% | ||
| 39 | MORGAN STANLEY | 147,232 | 1,270,000 | 0.38% | ||
| 40 | GROUP ONE TRADING LLC | 144,616 | 1,248,000 | 0.38% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 139,524 | 1,204,000 | 0.36% | ||
| 42 | WELLS FARGO & COMPANY/MN | 127,381 | 1,100,000 | 0.33% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 123,300 | 1,064,000 | 0.32% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 119,700 | 1,033,000 | 0.31% | ||
| 45 | Creative Planning | 110,759 | 956,000 | 0.29% | ||
| 46 | TEACHERS ADVISORS, LLC | 110,505 | 954,000 | 0.29% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,054 | 950,000 | 0.29% | ||
| 48 | CREDIT SUISSE AG/ | 110,114 | 950,000 | 0.29% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 74,159 | 640,000 | 0.19% | ||
| 50 | Zurcher Kantonalbank (Zurich Cantonalbank) | 71,694 | 619,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
