| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 9,259,260 | 28,373,000 | 33.29% | ||
| 2 | ORBIMED ADVISORS LLC | 3,586,100 | 11,547,000 | 13.55% | ||
| 3 | BlackRock Institutional Trust Company, N.A. | 2,103,010 | 6,772,000 | 7.95% | ||
| 4 | VANGUARD GROUP INC | 1,713,417 | 5,518,000 | 6.47% | ||
| 5 | BlackRock Fund Advisors | 1,546,441 | 4,980,000 | 5.84% | ||
| 6 | Broadfin Capital, LLC | 1,181,000 | 3,803,000 | 4.46% | ||
| 7 | DRIEHAUS CAPITAL MANAGEMENT LLC | 908,842 | 2,926,000 | 3.43% | ||
| 8 | Cormorant Asset Management, LP | 900,000 | 2,898,000 | 3.40% | ||
| 9 | STATE STREET CORP | 585,418 | 1,883,000 | 2.21% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 550,772 | 1,773,000 | 2.08% | ||
| 11 | Artal Group S.A. | 410,130 | 1,321,000 | 1.55% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 306,582 | 987,000 | 1.16% | ||
| 13 | GOLDMAN SACHS GROUP INC | 263,368 | 848,000 | 1.00% | ||
| 14 | Bank of New York Mellon Corp | 239,020 | 769,000 | 0.90% | ||
| 15 | TIAA CREF INVESTMENT MANAGEMENT LLC | 238,717 | 769,000 | 0.90% | ||
| 16 | Bruce & Co., Inc. | 233,515 | 751,000 | 0.88% | ||
| 17 | BlackRock Investment Management, LLC | 183,602 | 591,000 | 0.69% | ||
| 18 | NORTHERN TRUST CORP | 165,304 | 532,000 | 0.62% | ||
| 19 | JANE STREET GROUP, LLC | 164,912 | 531,000 | 0.62% | ||
| 20 | FMR LLC | 159,514 | 514,000 | 0.60% | ||
| 21 | MORGAN STANLEY | 146,210 | 471,000 | 0.55% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,238 | 445,000 | 0.52% | ||
| 23 | HAP Trading, LLC | 124,365 | 400,000 | 0.47% | ||
| 24 | DEUTSCHE BANK AG\ | 118,919 | 382,000 | 0.45% | ||
| 25 | BLAIR WILLIAM & CO/IL | 117,125 | 377,000 | 0.44% | ||
| 26 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 113,600 | 366,000 | 0.43% | ||
| 27 | ZACKS INVESTMENT MANAGEMENT | 102,252 | 329,000 | 0.39% | ||
| 28 | ADVENT CAPITAL MANAGEMENT /DE/ | 100,000 | 322,000 | 0.38% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,300 | 294,000 | 0.34% | ||
| 30 | TFS CAPITAL LLC | 89,598 | 289,000 | 0.34% | ||
| 31 | TEACHERS ADVISORS, LLC | 88,434 | 285,000 | 0.33% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 74,453 | 240,000 | 0.28% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 60,509 | 195,000 | 0.23% | ||
| 34 | WELLS FARGO & COMPANY/MN | 58,161 | 187,000 | 0.22% | ||
| 35 | VOYA INVESTMENT MANAGEMENT LLC | 57,596 | 185,000 | 0.22% | ||
| 36 | RHUMBLINE ADVISERS | 54,500 | 175,000 | 0.21% | ||
| 37 | METROPOLITAN LIFE INSURANCE CO/NY | 51,552 | 166,000 | 0.19% | ||
| 38 | DENVER INVESTMENT ADVISORS LLC | 50,722 | 163,000 | 0.19% | ||
| 39 | CREDIT SUISSE AG/ | 49,580 | 160,000 | 0.19% | ||
| 40 | Nationwide Fund Advisors | 47,367 | 153,000 | 0.18% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,670 | 137,000 | 0.16% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,800 | 135,000 | 0.16% | Call | |
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 40,863 | 131,578 | 0.15% | ||
| 44 | BLACKROCK ADVISORS LLC | 39,132 | 126,000 | 0.15% | ||
| 45 | Rotella Capital Management, Inc. | 36,496 | 118,000 | 0.14% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 32,926 | 106,000 | 0.12% | ||
| 47 | Tower Research Capital LLC (TRC) | 31,847 | 103,000 | 0.12% | ||
| 48 | ProShare Advisors LLC | 30,251 | 97,000 | 0.11% | ||
| 49 | Verition Fund Management LLC | 25,422 | 82,000 | 0.10% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 25,000 | 81,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
