| 1 |
QVT Financial LP |
9,259,260 |
34,103,000 |
31.19% |
|
|
| 2 |
Avoro Capital Advisors LLC |
2,638,071 |
10,473,000 |
9.58% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
2,441,500 |
9,693,000 |
8.87% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
2,284,562 |
9,070,000 |
8.30% |
|
|
| 5 |
VANGUARD GROUP INC |
1,931,255 |
7,667,000 |
7.01% |
|
|
| 6 |
BlackRock Fund Advisors |
1,745,169 |
6,928,000 |
6.34% |
|
|
| 7 |
GREAT POINT PARTNERS LLC |
920,300 |
3,654,000 |
3.34% |
|
|
| 8 |
Cormorant Asset Management, LP |
800,000 |
3,176,000 |
2.91% |
|
|
| 9 |
STATE STREET CORP |
664,993 |
2,644,000 |
2.42% |
|
|
| 10 |
NORTHERN TRUST CORP |
641,769 |
2,548,000 |
2.33% |
|
|
| 11 |
Artal Group S.A. |
410,130 |
1,628,000 |
1.49% |
|
|
| 12 |
PERCEPTIVE ADVISORS LLC |
402,717 |
1,599,000 |
1.46% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
337,371 |
1,339,000 |
1.22% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
321,143 |
1,275,000 |
1.17% |
|
|
| 15 |
ACUTA CAPITAL PARTNERS, LLC |
268,466 |
1,066,000 |
0.98% |
|
|
| 16 |
Bank of New York Mellon Corp |
260,875 |
1,036,000 |
0.95% |
|
|
| 17 |
Candriam S.C.A. |
240,000 |
953,000 |
0.87% |
|
|
| 18 |
Bruce & Co., Inc. |
233,515 |
927,000 |
0.85% |
|
|
| 19 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
208,755 |
829,000 |
0.76% |
|
|
| 20 |
BlackRock Investment Management, LLC |
184,827 |
734,000 |
0.67% |
|
|
| 21 |
Glenview Trust Co |
179,665 |
713,000 |
0.65% |
|
|
| 22 |
FMR LLC |
159,514 |
633,000 |
0.58% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
114,843 |
456,000 |
0.42% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
74,453 |
392,000 |
0.36% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
91,300 |
363,000 |
0.33% |
|
|
| 26 |
TEACHERS ADVISORS, LLC |
88,434 |
351,000 |
0.32% |
|
|
| 27 |
Nine Chapters Capital Management LLC |
81,600 |
324,000 |
0.30% |
|
|
| 28 |
TFS CAPITAL LLC |
77,691 |
308,000 |
0.28% |
|
|
| 29 |
MORGAN STANLEY |
68,044 |
270,000 |
0.25% |
|
|
| 30 |
Polar Capital LLP |
63,341 |
251,000 |
0.23% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
59,475 |
235,000 |
0.21% |
|
|
| 32 |
VOYA INVESTMENT MANAGEMENT LLC |
57,596 |
229,000 |
0.21% |
|
|
| 33 |
RHUMBLINE ADVISERS |
57,100 |
227,000 |
0.21% |
|
|
| 34 |
Airain ltd |
55,554 |
221,000 |
0.20% |
|
|
| 35 |
DENVER INVESTMENT ADVISORS LLC |
53,982 |
214,000 |
0.20% |
|
|
| 36 |
METROPOLITAN LIFE INSURANCE CO/NY |
51,552 |
205,000 |
0.19% |
|
|
| 37 |
BLAIR WILLIAM & CO/IL |
50,825 |
201,000 |
0.18% |
|
|
| 38 |
Nationwide Fund Advisors |
48,031 |
191,000 |
0.17% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
43,990 |
175,000 |
0.16% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
40,632 |
161,000 |
0.15% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
39,443 |
156,588 |
0.14% |
|
|
| 42 |
BLACKROCK ADVISORS LLC |
37,146 |
147,000 |
0.13% |
|
|
| 43 |
Connor, Clark & Lunn Investment Management Ltd. |
33,800 |
134,000 |
0.12% |
|
|
| 44 |
Weiss Multi-Strategy Advisers LLC |
30,000 |
119,000 |
0.11% |
|
|
| 45 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
28,800 |
114,000 |
0.10% |
Call |
|
| 46 |
PNC FINANCIAL SERVICES GROUP, INC. |
24,012 |
96,000 |
0.09% |
|
|
| 47 |
BANK OF AMERICA CORP /DE/ |
22,150 |
88,000 |
0.08% |
|
|
| 48 |
Aris Wealth Services, Inc. |
21,694 |
86,000 |
0.08% |
|
|
| 49 |
CREDIT SUISSE AG/ |
21,170 |
84,000 |
0.08% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
18,600 |
74,000 |
0.07% |
Put |
|
