| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Camber Capital Management LP | 11,000,000 | 19,360,000 | 19.18% | ||
| 2 | Abingworth LLP | 8,087,486 | 14,153,000 | 14.02% | ||
| 3 | ORACLE INVESTMENT MANAGEMENT INC | 3,700,000 | 6,512,000 | 6.45% | ||
| 4 | FRANKLIN RESOURCES INC | 3,615,200 | 6,363,000 | 6.31% | ||
| 5 | Visium Asset Management, LP | 3,101,182 | 5,458,000 | 5.41% | ||
| 6 | AMERIPRISE FINANCIAL INC | 2,512,803 | 4,423,000 | 4.38% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 3,520,000 | 3.49% | ||
| 8 | BlackRock Fund Advisors | 1,960,744 | 3,451,000 | 3.42% | ||
| 9 | Point72 Asset Management, L.P. | 1,361,832 | 2,397,000 | 2.38% | ||
| 10 | D. E. Shaw & Co., Inc. | 1,192,282 | 2,098,000 | 2.08% | ||
| 11 | CREDIT SUISSE AG/ | 1,154,889 | 2,033,000 | 2.01% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,124,940 | 1,980,000 | 1.96% | ||
| 13 | J. Goldman & Co LP | 1,050,000 | 1,848,000 | 1.83% | ||
| 14 | BALYASNY ASSET MANAGEMENT L.P. | 1,017,718 | 1,791,000 | 1.77% | ||
| 15 | Tekla Capital Management LLC | 1,005,000 | 1,769,000 | 1.75% | ||
| 16 | GREEN ARROW CAPITAL MANAGEMENT LLC | 1,000,000 | 1,760,000 | 1.74% | ||
| 17 | TURNER INVESTMENTS LLC | 826,370 | 1,454,000 | 1.44% | ||
| 18 | ALLIANCEBERNSTEIN L.P. | 769,630 | 1,355,000 | 1.34% | ||
| 19 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 756,696 | 1,332,000 | 1.32% | ||
| 20 | SABBY MANAGEMENT, LLC | 650,000 | 1,144,000 | 1.13% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 636,828 | 1,121,000 | 1.11% | ||
| 22 | GLG Partners LP | 614,900 | 1,082,000 | 1.07% | ||
| 23 | KENNEDY CAPITAL MANAGEMENT LLC | 593,685 | 1,045,000 | 1.04% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 514,400 | 905,000 | 0.90% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 504,990 | 889,000 | 0.88% | ||
| 26 | Artal Group S.A. | 500,000 | 880,000 | 0.87% | Call | |
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 486,300 | 856,000 | 0.85% | Call | |
| 28 | UBS AG | 460,339 | 811,000 | 0.80% | ||
| 29 | ORBIMED ADVISORS LLC | 400,000 | 704,000 | 0.70% | ||
| 30 | FMR LLC | 374,200 | 659,000 | 0.65% | ||
| 31 | MORGAN STANLEY | 317,917 | 559,000 | 0.55% | ||
| 32 | GOLDMAN SACHS GROUP INC | 283,568 | 499,000 | 0.49% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 272,700 | 480,000 | 0.48% | ||
| 34 | AMUNDI ASSET MANAGEMENT US, INC. | 270,000 | 475,000 | 0.47% | ||
| 35 | Spot Trading L.L.C | 268,800 | 473,000 | 0.47% | Call | |
| 36 | DEUTSCHE BANK AG\ | 219,409 | 386,000 | 0.38% | ||
| 37 | NATIXIS | 189,629 | 334,000 | 0.33% | ||
| 38 | State of New Jersey Common Pension Fund D | 187,000 | 329,000 | 0.33% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 184,200 | 324,000 | 0.32% | ||
| 40 | CITIGROUP INC | 152,635 | 269,000 | 0.27% | ||
| 41 | BASSO CAPITAL MANAGEMENT, L.P. | 151,400 | 266,000 | 0.26% | Call | |
| 42 | Jefferies Group LLC | 128,100 | 225,000 | 0.22% | Call | |
| 43 | LAZARD ASSET MANAGEMENT LLC | 117,668 | 207,000 | 0.21% | ||
| 44 | STATE STREET CORP | 105,286 | 185,000 | 0.18% | ||
| 45 | CARL DOMINO INC | 102,000 | 180,000 | 0.18% | ||
| 46 | ProShare Advisors LLC | 100,459 | 177,000 | 0.18% | ||
| 47 | BARCLAYS PLC | 176,200 | 176,000 | 0.17% | Call | |
| 48 | CITIGROUP INC | 94,600 | 166,000 | 0.16% | Call | |
| 49 | DekaBank Deutsche Girozentrale | 94,700 | 166,000 | 0.16% | ||
| 50 | Jefferies Group LLC | 90,500 | 159,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
