| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORACLE INVESTMENT MANAGEMENT INC | 5,818,805 | 8,903,000 | 14.66% | ||
| 2 | OppenheimerFunds, Inc. | 5,318,970 | 8,138,000 | 13.40% | ||
| 3 | Broadfin Capital, LLC | 4,675,216 | 7,153,000 | 11.78% | ||
| 4 | FMR LLC | 3,702,552 | 5,665,000 | 9.33% | ||
| 5 | CLEARBRIDGE, LLC | 2,379,341 | 3,640,000 | 5.99% | ||
| 6 | BlackRock Fund Advisors | 2,293,101 | 3,508,000 | 5.78% | ||
| 7 | Opaleye Management Inc. | 1,760,000 | 2,693,000 | 4.43% | ||
| 8 | D. E. Shaw & Co., Inc. | 1,382,753 | 2,116,000 | 3.48% | ||
| 9 | BALYASNY ASSET MANAGEMENT L.P. | 1,200,000 | 1,836,000 | 3.02% | ||
| 10 | PURA VIDA INVESTMENTS, LLC | 1,087,500 | 1,664,000 | 2.74% | ||
| 11 | AMERIPRISE FINANCIAL INC | 1,086,871 | 1,663,000 | 2.74% | ||
| 12 | J. Goldman & Co LP | 950,000 | 1,453,000 | 2.39% | ||
| 13 | SABBY MANAGEMENT, LLC | 870,792 | 1,332,000 | 2.19% | ||
| 14 | BAKER BROS. ADVISORS LP | 801,860 | 1,227,000 | 2.02% | ||
| 15 | UBS Group AG | 551,920 | 845,000 | 1.39% | ||
| 16 | GOLDMAN SACHS GROUP INC | 488,000 | 747,000 | 1.23% | Call | |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 479,000 | 733,000 | 1.21% | Call | |
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 720,000 | 1.19% | ||
| 19 | Raymond James Financial Services Advisors, Inc. | 372,652 | 570,000 | 0.94% | ||
| 20 | ORBIMED ADVISORS LLC | 350,000 | 536,000 | 0.88% | ||
| 21 | BARCLAYS PLC | 516,600 | 517,000 | 0.85% | Call | |
| 22 | GOLDMAN SACHS GROUP INC | 283,739 | 434,000 | 0.71% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 282,800 | 433,000 | 0.71% | Put | |
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 250,724 | 384,000 | 0.63% | ||
| 25 | State of New Jersey Common Pension Fund D | 187,000 | 286,000 | 0.47% | ||
| 26 | GSA CAPITAL PARTNERS LLP | 183,500 | 281,000 | 0.46% | ||
| 27 | A.R.T. Advisors, LLC | 133,962 | 204,000 | 0.34% | ||
| 28 | ProShare Advisors LLC | 131,158 | 201,000 | 0.33% | ||
| 29 | Mariner, LLC | 104,942 | 161,000 | 0.27% | ||
| 30 | STATE STREET CORP | 101,768 | 155,000 | 0.26% | ||
| 31 | Jefferies Group LLC | 100,000 | 153,000 | 0.25% | Put | |
| 32 | CARL DOMINO INC | 98,000 | 150,000 | 0.25% | ||
| 33 | GOLDMAN SACHS GROUP INC | 95,000 | 145,000 | 0.24% | Put | |
| 34 | CITIGROUP INC | 90,359 | 138,000 | 0.23% | ||
| 35 | DekaBank Deutsche Girozentrale | 88,000 | 132,000 | 0.22% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 79,241 | 121,000 | 0.20% | ||
| 37 | Frontier Wealth Management LLC | 77,000 | 118,000 | 0.19% | ||
| 38 | MORGAN STANLEY | 72,367 | 111,000 | 0.18% | ||
| 39 | Virtu KCG Holdings LLC | 72,126 | 110,000 | 0.18% | ||
| 40 | Jefferies Group LLC | 70,000 | 107,000 | 0.18% | ||
| 41 | TWO SIGMA SECURITIES, LLC | 67,623 | 103,000 | 0.17% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 66,116 | 102,000 | 0.17% | ||
| 43 | HSBC HOLDINGS PLC | 60,000 | 92,000 | 0.15% | ||
| 44 | DEUTSCHE BANK AG\ | 48,486 | 74,000 | 0.12% | ||
| 45 | J.P. Morgan Private Wealth Advisors LLC | 36,500 | 56,000 | 0.09% | ||
| 46 | Private Advisor Group, LLC | 35,618 | 54,000 | 0.09% | ||
| 47 | NORTHERN TRUST CORP | 31,229 | 48,000 | 0.08% | ||
| 48 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 31,631 | 48,000 | 0.08% | ||
| 49 | Creative Planning | 30,325 | 46,000 | 0.08% | ||
| 50 | CREDIT SUISSE AG/ | 28,798 | 44,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
