| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Camber Capital Management LP | 12,000,000 | 28,080,000 | 26.54% | ||
| 2 | Abingworth LLP | 8,087,486 | 18,925,000 | 17.89% | ||
| 3 | ORACLE INVESTMENT MANAGEMENT INC | 5,131,444 | 12,008,000 | 11.35% | ||
| 4 | D. E. Shaw & Co., Inc. | 2,270,805 | 5,313,000 | 5.02% | ||
| 5 | BAKER BROS. ADVISORS LP | 2,205,710 | 5,161,000 | 4.88% | ||
| 6 | Opaleye Management Inc. | 1,754,000 | 4,104,000 | 3.88% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 1,623,640 | 3,799,000 | 3.59% | ||
| 8 | AMERIPRISE FINANCIAL INC | 1,338,899 | 3,133,000 | 2.96% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,181,165 | 2,764,000 | 2.61% | ||
| 10 | Broadfin Capital, LLC | 991,883 | 2,321,000 | 2.19% | ||
| 11 | RENAISSANCE TECHNOLOGIES LLC | 732,490 | 1,714,000 | 1.62% | ||
| 12 | DEUTSCHE BANK AG\ | 706,873 | 1,653,000 | 1.56% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 677,928 | 1,586,000 | 1.50% | ||
| 14 | TURNER INVESTMENTS LLC | 581,240 | 1,360,000 | 1.29% | ||
| 15 | UBS Group AG | 503,228 | 1,178,000 | 1.11% | ||
| 16 | ARISTEIA CAPITAL, L.L.C. | 450,000 | 1,053,000 | 1.00% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 364,400 | 853,000 | 0.81% | Put | |
| 18 | ORBIMED ADVISORS LLC | 350,000 | 819,000 | 0.77% | ||
| 19 | MORGAN STANLEY | 280,077 | 656,000 | 0.62% | ||
| 20 | CITIGROUP INC | 250,921 | 587,000 | 0.55% | ||
| 21 | TWO SIGMA INVESTMENTS, LP | 245,862 | 575,000 | 0.54% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 485,000 | 0.46% | ||
| 23 | Healthcare Value Capital, LLC | 200,000 | 468,000 | 0.44% | ||
| 24 | Healthcare Value Capital, LLC | 200,000 | 468,000 | 0.44% | Call | |
| 25 | State of New Jersey Common Pension Fund D | 187,000 | 438,000 | 0.41% | ||
| 26 | CITADEL ADVISORS LLC | 184,877 | 433,000 | 0.41% | ||
| 27 | BARCLAYS PLC | 215,148 | 430,000 | 0.41% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,100 | 421,000 | 0.40% | Call | |
| 29 | GLG Partners LP | 171,974 | 402,000 | 0.38% | ||
| 30 | GOLDMAN SACHS GROUP INC | 166,041 | 389,000 | 0.37% | ||
| 31 | CADENCE CAPITAL MANAGEMENT LLC | 130,940 | 306,000 | 0.29% | ||
| 32 | JANE STREET GROUP, LLC | 115,174 | 270,000 | 0.26% | ||
| 33 | CREDIT SUISSE AG/ | 107,142 | 250,000 | 0.24% | ||
| 34 | STATE STREET CORP | 105,584 | 247,000 | 0.23% | ||
| 35 | Nine Chapters Capital Management LLC | 103,700 | 243,000 | 0.23% | ||
| 36 | Virtu KCG Holdings LLC | 96,512 | 226,000 | 0.21% | ||
| 37 | CARL DOMINO INC | 94,000 | 220,000 | 0.21% | ||
| 38 | Jefferies Group LLC | 90,500 | 212,000 | 0.20% | ||
| 39 | Cubist Systematic Strategies, LLC | 77,663 | 182,000 | 0.17% | ||
| 40 | BNP Paribas Asset Management Holding S.A. | 72,204 | 169,000 | 0.16% | ||
| 41 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 68,362 | 160,000 | 0.15% | ||
| 42 | HSBC HOLDINGS PLC | 60,000 | 140,000 | 0.13% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 54,747 | 128,000 | 0.12% | ||
| 44 | PEAK6 Group LLC | 50,800 | 119,000 | 0.11% | Call | |
| 45 | NORTHERN TRUST CORP | 33,783 | 79,000 | 0.07% | ||
| 46 | BARCLAYS PLC | 34,200 | 68,000 | 0.06% | Call | |
| 47 | BANK OF AMERICA CORP /DE/ | 28,832 | 67,000 | 0.06% | ||
| 48 | Rotella Capital Management, Inc. | 28,400 | 66,000 | 0.06% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 26,973 | 63,117 | 0.06% | ||
| 50 | J.P. Morgan Private Wealth Advisors LLC | 26,500 | 62,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
