| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Camber Capital Management LP | 12,000,000 | 13,080,000 | 18.65% | ||
| 2 | Abingworth LLP | 8,087,486 | 8,815,000 | 12.57% | ||
| 3 | Tekla Capital Management LLC | 5,643,412 | 6,151,000 | 8.77% | ||
| 4 | ORACLE INVESTMENT MANAGEMENT INC | 5,435,000 | 5,924,000 | 8.45% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 4,178,958 | 4,555,000 | 6.50% | ||
| 6 | Visium Asset Management, LP | 3,000,000 | 3,270,000 | 4.66% | ||
| 7 | FRANKLIN RESOURCES INC | 2,958,552 | 3,225,000 | 4.60% | ||
| 8 | D. E. Shaw & Co., Inc. | 2,302,754 | 2,510,000 | 3.58% | ||
| 9 | BlackRock Fund Advisors | 2,023,652 | 2,206,000 | 3.15% | ||
| 10 | AMERIPRISE FINANCIAL INC | 1,750,432 | 1,908,000 | 2.72% | ||
| 11 | BALYASNY ASSET MANAGEMENT L.P. | 1,487,165 | 1,621,000 | 2.31% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 1,171,466 | 1,277,000 | 1.82% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,021,100 | 1,113,000 | 1.59% | ||
| 14 | GREAT POINT PARTNERS LLC | 923,534 | 1,007,000 | 1.44% | ||
| 15 | J. Goldman & Co LP | 912,500 | 995,000 | 1.42% | ||
| 16 | CREDIT SUISSE AG/ | 716,415 | 781,000 | 1.11% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 690,700 | 753,000 | 1.07% | Put | |
| 18 | TURNER INVESTMENTS LLC | 673,890 | 735,000 | 1.05% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 613,600 | 669,000 | 0.95% | Call | |
| 20 | KENNEDY CAPITAL MANAGEMENT LLC | 583,714 | 636,000 | 0.91% | ||
| 21 | GLG Partners LP | 561,674 | 612,000 | 0.87% | ||
| 22 | UBS AG | 505,478 | 551,000 | 0.79% | ||
| 23 | Artal Group S.A. | 500,000 | 545,000 | 0.78% | Call | |
| 24 | GOLDMAN SACHS GROUP INC | 453,460 | 494,000 | 0.70% | ||
| 25 | Virtu KCG Holdings LLC | 416,832 | 454,000 | 0.65% | ||
| 26 | ORBIMED ADVISORS LLC | 400,000 | 436,000 | 0.62% | ||
| 27 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 396,732 | 432,000 | 0.62% | ||
| 28 | FMR LLC | 374,200 | 408,000 | 0.58% | ||
| 29 | MORGAN STANLEY | 358,805 | 391,000 | 0.56% | ||
| 30 | COLUMBUS CIRCLE INVESTORS | 357,861 | 390,000 | 0.56% | ||
| 31 | DEUTSCHE BANK AG\ | 351,562 | 382,000 | 0.54% | ||
| 32 | LAZARD ASSET MANAGEMENT LLC | 315,217 | 343,000 | 0.49% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 272,700 | 297,000 | 0.42% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 231,600 | 252,000 | 0.36% | Call | |
| 35 | Ghost Tree Capital, LLC | 200,000 | 218,000 | 0.31% | ||
| 36 | State of New Jersey Common Pension Fund D | 187,000 | 204,000 | 0.29% | ||
| 37 | CITIGROUP INC | 173,268 | 189,000 | 0.27% | ||
| 38 | CITADEL ADVISORS LLC | 159,196 | 174,000 | 0.25% | ||
| 39 | BARCLAYS PLC | 166,354 | 166,000 | 0.24% | ||
| 40 | BASSO CAPITAL MANAGEMENT, L.P. | 151,400 | 165,000 | 0.24% | Call | |
| 41 | Jefferies Group LLC | 128,100 | 140,000 | 0.20% | Call | |
| 42 | BARCLAYS PLC | 137,400 | 137,000 | 0.20% | Put | |
| 43 | STATE STREET CORP | 105,279 | 115,000 | 0.16% | ||
| 44 | WOLVERINE ASSET MANAGEMENT LLC | 1,387 | 111,000 | 0.16% | Put | |
| 45 | DekaBank Deutsche Girozentrale | 96,700 | 106,000 | 0.15% | ||
| 46 | CARL DOMINO INC | 92,000 | 100,000 | 0.14% | ||
| 47 | Jefferies Group LLC | 90,500 | 99,000 | 0.14% | ||
| 48 | ProShare Advisors LLC | 85,258 | 93,000 | 0.13% | ||
| 49 | Spot Trading L.L.C | 66,200 | 72,000 | 0.10% | Call | |
| 50 | BANK OF AMERICA CORP /DE/ | 64,209 | 70,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
