| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORACLE INVESTMENT MANAGEMENT INC | 6,645,793 | 12,561,000 | 13.40% | ||
| 2 | FMR LLC | 5,702,069 | 10,777,000 | 11.50% | ||
| 3 | TAMARACK ADVISERS, LP | 5,500,000 | 10,395,000 | 11.09% | ||
| 4 | OppenheimerFunds, Inc. | 5,323,360 | 10,061,000 | 10.73% | ||
| 5 | Broadfin Capital, LLC | 4,175,216 | 7,891,000 | 8.42% | ||
| 6 | BAKER BROS. ADVISORS LP | 2,205,710 | 4,169,000 | 4.45% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 2,110,357 | 3,989,000 | 4.26% | ||
| 8 | BlackRock Fund Advisors | 2,065,013 | 3,903,000 | 4.16% | ||
| 9 | CLEARBRIDGE, LLC | 2,004,747 | 3,789,000 | 4.04% | ||
| 10 | Opaleye Management Inc. | 1,760,000 | 3,326,000 | 3.55% | ||
| 11 | D. E. Shaw & Co., Inc. | 1,513,370 | 2,860,000 | 3.05% | ||
| 12 | AMERIPRISE FINANCIAL INC | 1,151,840 | 2,176,000 | 2.32% | ||
| 13 | J. Goldman & Co LP | 1,040,000 | 1,966,000 | 2.10% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 619,740 | 1,171,000 | 1.25% | ||
| 15 | UBS Group AG | 516,758 | 977,000 | 1.04% | ||
| 16 | GOLDMAN SACHS GROUP INC | 498,200 | 942,000 | 1.01% | Put | |
| 17 | GOLDMAN SACHS GROUP INC | 498,600 | 942,000 | 1.01% | Call | |
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 889,000 | 0.95% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 461,704 | 873,000 | 0.93% | ||
| 20 | GOLDMAN SACHS GROUP INC | 446,965 | 845,000 | 0.90% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 431,300 | 815,000 | 0.87% | Call | |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 430,300 | 813,000 | 0.87% | Put | |
| 23 | Healthcare Value Capital, LLC | 400,000 | 756,000 | 0.81% | Call | |
| 24 | ORBIMED ADVISORS LLC | 350,000 | 662,000 | 0.71% | ||
| 25 | CITADEL ADVISORS LLC | 277,801 | 525,000 | 0.56% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 264,900 | 501,000 | 0.53% | ||
| 27 | State of New Jersey Common Pension Fund D | 187,000 | 353,000 | 0.38% | ||
| 28 | Raymond James Financial Services Advisors, Inc. | 159,700 | 302,000 | 0.32% | ||
| 29 | DEUTSCHE BANK AG\ | 156,826 | 295,000 | 0.31% | ||
| 30 | ProShare Advisors LLC | 142,501 | 269,000 | 0.29% | ||
| 31 | Virtu KCG Holdings LLC | 137,745 | 260,000 | 0.28% | ||
| 32 | MORGAN STANLEY | 133,152 | 252,000 | 0.27% | ||
| 33 | ACADIAN ASSET MANAGEMENT LLC | 122,620 | 232,000 | 0.25% | ||
| 34 | STATE STREET CORP | 105,590 | 200,000 | 0.21% | ||
| 35 | Mariner, LLC | 104,942 | 198,000 | 0.21% | ||
| 36 | BARCLAYS PLC | 195,814 | 196,000 | 0.21% | ||
| 37 | Frontier Wealth Management LLC | 102,000 | 193,000 | 0.21% | ||
| 38 | CITIGROUP INC | 98,049 | 186,000 | 0.20% | ||
| 39 | CARL DOMINO INC | 98,000 | 185,000 | 0.20% | ||
| 40 | BARCLAYS PLC | 179,600 | 180,000 | 0.19% | Put | |
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 90,649 | 170,000 | 0.18% | ||
| 42 | A.R.T. Advisors, LLC | 64,462 | 121,000 | 0.13% | ||
| 43 | Airain ltd | 59,855 | 113,000 | 0.12% | ||
| 44 | HSBC HOLDINGS PLC | 60,000 | 113,000 | 0.12% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 51,251 | 97,000 | 0.10% | ||
| 46 | LPL Financial LLC | 46,000 | 85,000 | 0.09% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 44,075 | 83,000 | 0.09% | ||
| 48 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 39,231 | 74,000 | 0.08% | ||
| 49 | Private Advisor Group, LLC | 37,697 | 71,000 | 0.08% | ||
| 50 | BARCLAYS PLC | 70,200 | 70,000 | 0.07% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
