| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Camber Capital Management LP | 10,000,000 | 24,600,000 | 19.19% | ||
| 2 | Abingworth LLP | 8,087,486 | 19,814,000 | 15.45% | ||
| 3 | ORACLE INVESTMENT MANAGEMENT INC | 5,184,225 | 12,753,000 | 9.95% | ||
| 4 | FMR LLC | 3,773,369 | 9,282,000 | 7.24% | ||
| 5 | Broadfin Capital, LLC | 3,525,216 | 8,672,000 | 6.76% | ||
| 6 | Tamarack Capital Management, LLC | 3,224,690 | 7,933,000 | 6.19% | ||
| 7 | BAKER BROS. ADVISORS LP | 2,205,710 | 5,426,000 | 4.23% | ||
| 8 | D. E. Shaw & Co., Inc. | 2,123,739 | 5,224,000 | 4.07% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 1,924,380 | 4,734,000 | 3.69% | ||
| 10 | Opaleye Management Inc. | 1,754,000 | 4,315,000 | 3.37% | ||
| 11 | AMERIPRISE FINANCIAL INC | 1,520,488 | 3,740,000 | 2.92% | ||
| 12 | CLEARBRIDGE, LLC | 940,562 | 2,314,000 | 1.80% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 859,954 | 2,115,000 | 1.65% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 636,000 | 1,565,000 | 1.22% | Call | |
| 15 | UBS Group AG | 513,509 | 1,263,000 | 0.98% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 484,001 | 1,191,000 | 0.93% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 483,500 | 1,189,000 | 0.93% | Put | |
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 1,157,000 | 0.90% | ||
| 19 | Healthcare Value Capital, LLC | 400,000 | 984,000 | 0.77% | Call | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 374,651 | 921,000 | 0.72% | ||
| 21 | ORBIMED ADVISORS LLC | 350,000 | 861,000 | 0.67% | ||
| 22 | DEUTSCHE BANK AG\ | 307,864 | 757,000 | 0.59% | ||
| 23 | J. Goldman & Co LP | 304,445 | 749,000 | 0.58% | ||
| 24 | MORGAN STANLEY | 287,256 | 707,000 | 0.55% | ||
| 25 | Bank of New York Mellon Corp | 267,449 | 657,000 | 0.51% | ||
| 26 | GOLDMAN SACHS GROUP INC | 208,114 | 512,000 | 0.40% | ||
| 27 | CITADEL ADVISORS LLC | 187,437 | 461,000 | 0.36% | ||
| 28 | State of New Jersey Common Pension Fund D | 187,000 | 460,000 | 0.36% | ||
| 29 | BARCLAYS PLC | 190,500 | 381,000 | 0.30% | Put | |
| 30 | CITIGROUP INC | 148,000 | 364,000 | 0.28% | ||
| 31 | BARCLAYS PLC | 167,865 | 336,000 | 0.26% | ||
| 32 | Mariner, LLC | 104,942 | 258,000 | 0.20% | ||
| 33 | GLG Partners LP | 103,590 | 255,000 | 0.20% | ||
| 34 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 101,528 | 250,000 | 0.19% | ||
| 35 | CARL DOMINO INC | 94,000 | 231,000 | 0.18% | ||
| 36 | HSBC HOLDINGS PLC | 60,000 | 148,000 | 0.12% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 55,105 | 135,000 | 0.11% | ||
| 38 | BARCLAYS PLC | 65,700 | 131,000 | 0.10% | Call | |
| 39 | IRIDIAN ASSET MANAGEMENT LLC/CT | 50,775 | 125,000 | 0.10% | ||
| 40 | Virtu KCG Holdings LLC | 49,228 | 121,000 | 0.09% | ||
| 41 | Private Advisor Group, LLC | 35,118 | 86,000 | 0.07% | ||
| 42 | Creative Planning | 26,750 | 66,000 | 0.05% | ||
| 43 | J.P. Morgan Private Wealth Advisors LLC | 26,500 | 65,000 | 0.05% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 25,771 | 63,000 | 0.05% | ||
| 45 | Geduld E E | 25,000 | 62,000 | 0.05% | ||
| 46 | JANE STREET GROUP, LLC | 24,885 | 61,000 | 0.05% | ||
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 24,479 | 60,218 | 0.05% | ||
| 48 | B. Riley Wealth Advisors, Inc. | 20,950 | 52,000 | 0.04% | ||
| 49 | Cambridge Investment Research Advisors, Inc. | 19,777 | 49,000 | 0.04% | ||
| 50 | CYPRESS CAPITAL MANAGEMENT LLC | 20,000 | 49,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
