| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 25,052,380 | 77,161,000 | 23.34% | ||
| 2 | BAKER BROS. ADVISORS LP | 22,169,509 | 68,282,000 | 20.66% | ||
| 3 | ORACLE INVESTMENT MANAGEMENT INC | 7,935,000 | 24,440,000 | 7.39% | ||
| 4 | OppenheimerFunds, Inc. | 6,537,470 | 20,135,000 | 6.09% | ||
| 5 | Rock Springs Capital Management LP | 4,991,500 | 15,374,000 | 4.65% | ||
| 6 | ACADIAN ASSET MANAGEMENT LLC | 4,579,611 | 14,104,000 | 4.27% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 4,330,484 | 13,338,000 | 4.04% | ||
| 8 | BlackRock Fund Advisors | 3,501,818 | 10,786,000 | 3.26% | ||
| 9 | CLEARBRIDGE, LLC | 3,289,261 | 10,131,000 | 3.06% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 3,037,536 | 9,356,000 | 2.83% | ||
| 11 | Broadfin Capital, LLC | 2,833,649 | 8,728,000 | 2.64% | ||
| 12 | FARALLON CAPITAL MANAGEMENT LLC | 2,105,000 | 6,483,000 | 1.96% | ||
| 13 | FMR LLC | 2,042,925 | 6,292,000 | 1.90% | ||
| 14 | HIGHLAND CAPITAL MANAGEMENT LP | 1,097,000 | 3,379,000 | 1.02% | ||
| 15 | J. Goldman & Co LP | 1,077,200 | 3,318,000 | 1.00% | ||
| 16 | GOLDMAN SACHS GROUP INC | 752,934 | 2,319,000 | 0.70% | ||
| 17 | UBS Group AG | 681,318 | 2,098,000 | 0.63% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 558,700 | 1,721,000 | 0.52% | Put | |
| 19 | TWO SIGMA INVESTMENTS, LP | 557,954 | 1,718,000 | 0.52% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 551,823 | 1,700,000 | 0.51% | ||
| 21 | MORGAN STANLEY | 518,415 | 1,596,000 | 0.48% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 518,000 | 1,595,000 | 0.48% | Call | |
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 1,449,000 | 0.44% | ||
| 24 | Healthcare Value Capital, LLC | 450,000 | 1,386,000 | 0.42% | ||
| 25 | State of Tennessee, Department of Treasury | 410,200 | 1,263,000 | 0.38% | ||
| 26 | AMERIPRISE FINANCIAL INC | 392,356 | 1,208,000 | 0.37% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 386,000 | 1,189,000 | 0.36% | ||
| 28 | ASCEND CAPITAL, LLC | 374,719 | 1,154,000 | 0.35% | ||
| 29 | DEUTSCHE BANK AG\ | 363,505 | 1,118,000 | 0.34% | ||
| 30 | ORBIMED ADVISORS LLC | 350,000 | 1,078,000 | 0.33% | ||
| 31 | JPMORGAN CHASE & CO | 298,010 | 918,000 | 0.28% | ||
| 32 | D. E. Shaw & Co., Inc. | 269,787 | 831,000 | 0.25% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 268,722 | 828,000 | 0.25% | ||
| 34 | PURA VIDA INVESTMENTS, LLC | 250,000 | 770,000 | 0.23% | ||
| 35 | State of New Jersey Common Pension Fund D | 226,033 | 696,000 | 0.21% | ||
| 36 | GROUP ONE TRADING LLC | 225,034 | 693,000 | 0.21% | ||
| 37 | ProShare Advisors LLC | 165,096 | 508,000 | 0.15% | ||
| 38 | STATE STREET CORP | 164,417 | 506,000 | 0.15% | ||
| 39 | TWO SIGMA ADVISERS, LP | 156,846 | 483,000 | 0.15% | ||
| 40 | CITADEL ADVISORS LLC | 146,472 | 451,000 | 0.14% | ||
| 41 | Raymond James Financial Services Advisors, Inc. | 141,600 | 436,000 | 0.13% | ||
| 42 | WOLVERINE TRADING LP /BD | 133,900 | 412,000 | 0.12% | Call | |
| 43 | LPL Financial LLC | 125,648 | 388,000 | 0.12% | ||
| 44 | GOLDMAN SACHS GROUP INC | 120,000 | 370,000 | 0.11% | Put | |
| 45 | Virtu KCG Holdings LLC | 118,088 | 364,000 | 0.11% | ||
| 46 | GEODE CAPITAL MANAGEMENT, LLC | 117,094 | 360,000 | 0.11% | ||
| 47 | Jefferies Group LLC | 110,000 | 339,000 | 0.10% | ||
| 48 | Mariner, LLC | 104,984 | 323,000 | 0.10% | ||
| 49 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 101,690 | 313,000 | 0.09% | ||
| 50 | Jefferies Group LLC | 100,000 | 308,000 | 0.09% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
