| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 12,850,000 | 88,280,000 | 9.51% | ||
| 2 | VANGUARD GROUP INC | 10,735,985 | 73,757,000 | 7.95% | ||
| 3 | FMR LLC | 9,218,937 | 63,334,000 | 6.83% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,331,000 | 57,234,000 | 6.17% | ||
| 5 | WESTFIELD CAPITAL MANAGEMENT CO LP | 8,312,820 | 57,109,000 | 6.16% | ||
| 6 | BlackRock Fund Advisors | 7,945,954 | 54,589,000 | 5.88% | ||
| 7 | Camber Capital Management LP | 7,500,000 | 51,525,000 | 5.55% | ||
| 8 | STATE STREET CORP | 5,787,408 | 39,761,000 | 4.29% | ||
| 9 | PointState Capital LP | 5,400,000 | 37,098,000 | 4.00% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 4,903,278 | 33,686,000 | 3.63% | ||
| 11 | PUTNAM INVESTMENTS LLC | 3,280,920 | 22,540,000 | 2.43% | ||
| 12 | Palo Alto Investors LP | 2,231,717 | 15,332,000 | 1.65% | ||
| 13 | NORTHERN TRUST CORP | 2,012,634 | 13,827,000 | 1.49% | ||
| 14 | COLUMBUS CIRCLE INVESTORS | 1,898,144 | 13,040,000 | 1.41% | ||
| 15 | BNP Paribas Asset Management Holding S.A. | 1,782,857 | 12,248,000 | 1.32% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,723,883 | 11,844,000 | 1.28% | ||
| 17 | AMERIPRISE FINANCIAL INC | 1,709,635 | 11,746,000 | 1.27% | ||
| 18 | OppenheimerFunds, Inc. | 1,620,560 | 11,133,000 | 1.20% | ||
| 19 | GOLDMAN SACHS GROUP INC | 1,598,900 | 10,984,000 | 1.18% | Put | |
| 20 | Opaleye Management Inc. | 1,525,000 | 10,477,000 | 1.13% | ||
| 21 | NORGES BANK | 1,495,354 | 10,273,000 | 1.11% | ||
| 22 | Alberta Investment Management Corp | 1,379,360 | 9,476,000 | 1.02% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,275,700 | 8,764,000 | 0.94% | Put | |
| 24 | HighVista Strategies LLC | 1,200,000 | 8,244,000 | 0.89% | ||
| 25 | GENERAL AMERICAN INVESTORS CO INC | 1,200,000 | 8,244,000 | 0.89% | ||
| 26 | CQS Cayman LP | 1,200,000 | 8,244,000 | 0.89% | ||
| 27 | Elk Creek Partners, LLC | 1,152,466 | 7,917,000 | 0.85% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 1,042,014 | 7,158,000 | 0.77% | ||
| 29 | Bank of New York Mellon Corp | 935,352 | 6,426,000 | 0.69% | ||
| 30 | GOLDMAN SACHS GROUP INC | 839,048 | 5,764,000 | 0.62% | ||
| 31 | GROUP ONE TRADING LLC | 836,416 | 5,746,000 | 0.62% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 804,399 | 5,526,000 | 0.60% | ||
| 33 | Granite Point Capital Management, L.P. | 800,000 | 5,496,000 | 0.59% | ||
| 34 | Invesco Ltd. | 763,221 | 5,243,000 | 0.57% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 757,200 | 5,202,000 | 0.56% | Call | |
| 36 | AQR CAPITAL MANAGEMENT LLC | 722,296 | 4,962,000 | 0.53% | ||
| 37 | CITY NATIONAL BANK | 720,785 | 4,951,000 | 0.53% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 571,443 | 3,926,000 | 0.42% | ||
| 39 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 559,620 | 3,845,000 | 0.41% | ||
| 40 | BARCLAYS PLC | 597,600 | 3,586,000 | 0.39% | Call | |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 498,537 | 3,425,000 | 0.37% | ||
| 42 | MORGAN STANLEY | 469,049 | 3,223,000 | 0.35% | ||
| 43 | BlackRock Investment Management, LLC | 448,920 | 3,084,000 | 0.33% | ||
| 44 | ROYCE & ASSOCIATES LP | 440,602 | 3,027,000 | 0.33% | ||
| 45 | JS Capital Management LLC | 435,000 | 2,988,000 | 0.32% | ||
| 46 | CREDIT SUISSE AG/ | 406,256 | 2,791,000 | 0.30% | ||
| 47 | JPMORGAN CHASE & CO | 399,506 | 2,744,000 | 0.30% | ||
| 48 | Rhenman & Partners Asset Management AB | 397,000 | 2,727,000 | 0.29% | ||
| 49 | D. E. Shaw & Co., Inc. | 365,528 | 2,512,000 | 0.27% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 385,800 | 2,492,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
