| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,380,046 | 85,231,000 | 10.90% | ||
| 2 | Sarissa Capital Management LP | 12,000,000 | 76,440,000 | 9.78% | ||
| 3 | VANGUARD GROUP INC | 10,655,939 | 67,878,000 | 8.68% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,968,993 | 50,762,000 | 6.49% | ||
| 5 | BlackRock Fund Advisors | 6,439,785 | 41,021,000 | 5.25% | ||
| 6 | STATE STREET CORP | 5,772,991 | 36,774,000 | 4.70% | ||
| 7 | FRANKLIN RESOURCES INC | 5,038,427 | 32,095,000 | 4.11% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 4,828,394 | 30,757,000 | 3.93% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 4,399,981 | 28,028,000 | 3.58% | ||
| 10 | AQR CAPITAL MANAGEMENT LLC | 3,882,830 | 24,734,000 | 3.16% | ||
| 11 | Palo Alto Investors LP | 2,275,603 | 14,496,000 | 1.85% | ||
| 12 | NORGES BANK | 2,123,115 | 13,525,000 | 1.73% | ||
| 13 | PointState Capital LP | 1,950,000 | 12,422,000 | 1.59% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,797,411 | 11,450,000 | 1.46% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,727,200 | 11,002,000 | 1.41% | Put | |
| 16 | Opaleye Management Inc. | 1,660,000 | 10,574,000 | 1.35% | ||
| 17 | AMERIPRISE FINANCIAL INC | 1,624,245 | 10,347,000 | 1.32% | ||
| 18 | MORGAN STANLEY | 1,406,770 | 8,962,000 | 1.15% | ||
| 19 | HealthCor Management, L.P. | 1,350,000 | 8,600,000 | 1.10% | ||
| 20 | GENERAL AMERICAN INVESTORS CO INC | 1,200,000 | 7,644,000 | 0.98% | ||
| 21 | BARCLAYS PLC | 1,223,200 | 7,339,000 | 0.94% | Call | |
| 22 | DEUTSCHE BANK AG\ | 1,058,740 | 6,741,000 | 0.86% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 1,007,344 | 6,416,000 | 0.82% | ||
| 24 | CQS Cayman LP | 1,000,000 | 6,370,000 | 0.81% | ||
| 25 | SOROS FUND MANAGEMENT LLC | 1,000,000 | 6,370,000 | 0.81% | ||
| 26 | Bank of New York Mellon Corp | 987,043 | 6,288,000 | 0.80% | ||
| 27 | NORTHERN TRUST CORP | 984,610 | 6,272,000 | 0.80% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 890,300 | 5,671,000 | 0.73% | Call | |
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 871,817 | 5,553,000 | 0.71% | ||
| 30 | GOLDMAN SACHS GROUP INC | 785,700 | 5,005,000 | 0.64% | Put | |
| 31 | GROUP ONE TRADING LLC | 769,421 | 4,901,000 | 0.63% | ||
| 32 | Elk Creek Partners, LLC | 627,968 | 4,000,000 | 0.51% | ||
| 33 | CITY NATIONAL BANK | 624,730 | 3,980,000 | 0.51% | ||
| 34 | BNP Paribas Asset Management Holding S.A. | 621,039 | 3,956,000 | 0.51% | ||
| 35 | AXA S.A. | 568,527 | 3,622,000 | 0.46% | ||
| 36 | NOMURA HOLDINGS INC | 563,344 | 3,592,000 | 0.46% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 551,319 | 3,512,000 | 0.45% | ||
| 38 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 548,478 | 3,494,000 | 0.45% | ||
| 39 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 545,255 | 3,473,000 | 0.44% | ||
| 40 | VAN ECK ASSOCIATES CORP | 534,249 | 3,403,000 | 0.44% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 517,570 | 3,297,000 | 0.42% | ||
| 42 | GOLDMAN SACHS GROUP INC | 491,463 | 3,130,000 | 0.40% | ||
| 43 | ROYCE & ASSOCIATES LP | 480,602 | 3,061,000 | 0.39% | ||
| 44 | BlackRock Investment Management, LLC | 451,299 | 2,875,000 | 0.37% | ||
| 45 | Granite Point Capital Management, L.P. | 450,000 | 2,867,000 | 0.37% | ||
| 46 | D. E. Shaw & Co., Inc. | 436,153 | 2,779,000 | 0.36% | ||
| 47 | CREDIT SUISSE AG/ | 408,751 | 2,603,000 | 0.33% | ||
| 48 | JPMORGAN CHASE & CO | 394,159 | 2,511,000 | 0.32% | ||
| 49 | Rhenman & Partners Asset Management AB | 390,000 | 2,484,000 | 0.32% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 385,800 | 2,458,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
