| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PUTNAM INVESTMENTS LLC | 18,328,660 | 117,120,000 | 13.32% | ||
| 2 | Sarissa Capital Management LP | 12,850,000 | 82,111,000 | 9.34% | ||
| 3 | VANGUARD GROUP INC | 12,465,396 | 79,653,000 | 9.06% | ||
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 11,104,978 | 70,961,000 | 8.07% | ||
| 5 | BlackRock Fund Advisors | 7,880,858 | 50,359,000 | 5.73% | ||
| 6 | STATE STREET CORP | 5,694,759 | 36,389,000 | 4.14% | ||
| 7 | Consonance Capital Management LP | 5,575,742 | 35,629,000 | 4.05% | ||
| 8 | Camber Capital Management LP | 5,405,235 | 34,539,000 | 3.93% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,312,361 | 33,946,000 | 3.86% | ||
| 10 | PointState Capital LP | 4,700,000 | 30,033,000 | 3.41% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 4,504,518 | 28,784,000 | 3.27% | ||
| 12 | FMR LLC | 3,540,246 | 22,622,000 | 2.57% | ||
| 13 | Palo Alto Investors LP | 2,248,317 | 14,367,000 | 1.63% | ||
| 14 | NORTHERN TRUST CORP | 2,133,041 | 13,630,000 | 1.55% | ||
| 15 | OppenheimerFunds, Inc. | 1,860,860 | 11,891,000 | 1.35% | ||
| 16 | Elk Creek Partners, LLC | 1,751,813 | 11,194,000 | 1.27% | ||
| 17 | NORGES BANK | 1,665,993 | 10,645,000 | 1.21% | ||
| 18 | TAMARACK ADVISERS, LP | 1,600,000 | 10,224,000 | 1.16% | SH | |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1,271,477 | 8,124,000 | 0.92% | ||
| 20 | Opaleye Management Inc. | 1,250,000 | 7,988,000 | 0.91% | ||
| 21 | Jupiter Investment Management Ltd | 1,223,362 | 7,817,000 | 0.89% | ||
| 22 | GENERAL AMERICAN INVESTORS CO INC | 1,200,000 | 7,668,000 | 0.87% | ||
| 23 | D. E. Shaw & Co., Inc. | 1,104,998 | 7,061,000 | 0.80% | ||
| 24 | PRICE MICHAEL F | 1,075,000 | 6,869,000 | 0.78% | ||
| 25 | OXFORD ASSET MANAGEMENT LLP | 984,441 | 6,291,000 | 0.72% | ||
| 26 | JS Capital Management LLC | 868,700 | 5,551,000 | 0.63% | ||
| 27 | Bank of New York Mellon Corp | 857,131 | 5,477,000 | 0.62% | ||
| 28 | HighVista Strategies LLC | 807,100 | 5,157,000 | 0.59% | ||
| 29 | DEUTSCHE BANK AG\ | 792,836 | 5,064,000 | 0.58% | ||
| 30 | HBK INVESTMENTS L P | 779,800 | 4,983,000 | 0.57% | ||
| 31 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 628,962 | 4,019,000 | 0.46% | ||
| 32 | PDT Partners, LLC | 618,187 | 3,950,000 | 0.45% | ||
| 33 | Rhenman & Partners Asset Management AB | 600,000 | 3,834,000 | 0.44% | ||
| 34 | GOLDMAN SACHS GROUP INC | 590,462 | 3,773,000 | 0.43% | ||
| 35 | BlackRock Investment Management, LLC | 588,332 | 3,759,000 | 0.43% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 560,139 | 3,579,000 | 0.41% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 558,556 | 3,570,000 | 0.41% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 497,384 | 3,178,000 | 0.36% | ||
| 39 | BELLEVUE GROUP AG | 495,000 | 3,163,000 | 0.36% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 378,568 | 2,419,000 | 0.28% | ||
| 41 | ROYCE & ASSOCIATES LP | 375,352 | 2,398,000 | 0.27% | ||
| 42 | J. Goldman & Co LP | 371,700 | 2,375,000 | 0.27% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 363,900 | 2,325,000 | 0.26% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 355,719 | 2,273,000 | 0.26% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 342,185 | 2,187,000 | 0.25% | ||
| 46 | Alberta Investment Management Corp | 328,620 | 2,100,000 | 0.24% | ||
| 47 | JPMORGAN CHASE & CO | 308,601 | 1,971,000 | 0.22% | ||
| 48 | AMERIPRISE FINANCIAL INC | 306,497 | 1,958,000 | 0.22% | ||
| 49 | TEACHERS ADVISORS, LLC | 305,401 | 1,952,000 | 0.22% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 298,000 | 1,904,000 | 0.22% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
